SUPPORT FOR THYROID CANCER AND OTHER THYROID DISEASES IN BELARUS

对白俄罗斯甲状腺癌和其他甲状腺疾病的支持

• 批准号: 10027037
• 负责人: ALEXANDER ROZHKO
• 金额: $ 4.94万
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2020-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10027037
• 关键词: Accidents; Address; Affect; Age; Area; Behavior; Belarus; Benign; Chernobyl Nuclear Accident; Clinical Data; Contracts; Data; Data Set; Diet; Disease; Dose; Evaluation; Exposure to; Hypothyroidism; Individual; Lesion; Life; Malignant Neoplasms; Malignant neoplasm of thyroid; Measurement; Measures; Medical; Mothers; Nodule; Pathology; Persons; Questionnaires; Radiation; Radioactive Iodine; Registries; Study Subject; Surveys; Thyroid Diseases; Thyroid Gland; Thyroiditis; Time; Uncertainty; Update; Vital Status; base; cohort; epidemiologic data; epidemiology study; follow-up; in utero; memory recall; neoplasm registry; nuclear power; screening; tumor

The contract is for the continuation of the “Study of Thyroid Cancer and Other Thyroid Diseases in Belarus”, a large-scale epidemiological study detecting thyroid and other pathology in persons who have been exposed to radiation as released by the accident at the Chernobyl Nuclear Power Station in April 26, 1986. The study involves two cohorts: (1) the “main cohort” that was established in the late 1990s and consists of 11,732 subjects who were age 18 or under at the time of the accident, had their dose to the thyroid gland measured, and lived in the Chernobyl affected areas in Belarus; and (2) the “in utero cohort” that was established in 2017 and consists of 2.965 persons who were exposed to Chernobyl fallout radiation in utero and early post-natal life. The main emphasis of this contract is to conduct medical screening for thyroid cancer and diseases in the recently established in-utero cohort. The main cohort, after having undergone three cycles of thyroid screening, transitioned to linkage-based passive follow-up. The specific objectives are: for the in utero cohort, (1) to conduct medical screening for thyroid cancer and thyroid non-cancer disease; (2) to evaluate the reliability of questionnaire-based doses previously reconstructed; for both the main and in utero cohorts: (3) to maintain passive follow-up to update occurrences of thyroid cancer, other cancer and thyroid non-cancer disease, through linkage with the Chernobyl State Registry and the National Belarusian Cancer Registry, (4) update demographic, clinical and epidemiologic data through a mail survey. Medical screening of in utero cohort focuses on thyroid cancer but also ascertain a wide spectrum of benign lesions, including benign tumors, nodules, functional changes (hyper- or hypothyroidism, thyroiditis, etc.), which have been associated with radioiodine exposure. Another important aspect of the study is the evaluation of uncertainty of questionnaire-based doses due to memory recall. NCI’s previous study shows that if dose-related measurements are available for study subjects, the quality of individual behavior and dietary data has, in general, a small influence on the results of the retrospective dose assessment. However, direct thyroid measurements are available only for around 15% of mothers of in utero cohort subjects; evaluation of uncertainty in doses due to possibly poor memory recall is important for this study. Another task for the contract is to update the dataset for the main and in-utero cohort with information obtained as a result of record linkage to the State Chernobyl Registry and National Belarusian Cancer Registry. We are also updating vital status and last known address for the subjects of main cohort through a mail survey.

该合同是为了继续进行“白俄罗斯甲状腺癌和其他甲状腺疾病研究”，这是一项大规模的流行病学研究，旨在检测1986年4月26日切尔诺贝利核电站事故释放的辐射对人的甲状腺和其他病变。这项研究涉及两个队列：（1）“主要队列”，建立于1990年代后期，由11 732名受试者组成，他们在事故发生时年龄在18岁或18岁以下，接受了甲状腺剂量测量，居住在白俄罗斯受切尔诺贝利影响的地区;以及（2）2017年建立的“子宫内队列”，由2，965名在子宫内和产后早期暴露于切尔诺贝利沉降物辐射的人组成。该合同的主要重点是对最近建立的子宫内队列进行甲状腺癌和疾病的医疗筛查。主要队列在经历了三个周期的甲状腺筛查后，过渡到基于联系的被动随访。 具体目标是：对于子宫内队列，（1）进行甲状腺癌和甲状腺非癌症疾病的医学筛查;（2）评价先前重建的基于顺铂的剂量的可靠性;对于主要队列和子宫内队列：（3）保持被动随访，以更新甲状腺癌、其他癌症和甲状腺非癌症疾病的发生率，通过与切尔诺贝利国家登记处和白俄罗斯国家癌症登记处的联系，（4）通过邮件调查更新人口、临床和流行病学数据。 子宫内队列的医学筛查侧重于甲状腺癌，但也确定广泛的良性病变，包括良性肿瘤、结节、功能变化（甲状腺功能亢进或减退、甲状腺炎等），这与放射性碘暴露有关。该研究的另一个重要方面是评估由于记忆回忆而导致的基于阿托洛尔的剂量的不确定性。NCI先前的研究表明，如果研究受试者可获得剂量相关测量值，则个人行为和饮食数据的质量通常对回顾性剂量评估的结果影响较小。然而，仅约15%的宫内队列受试者的母亲可进行直接甲状腺测量;由于记忆回忆可能较差而导致的剂量不确定性评价对本研究很重要。 合同的另一项任务是更新主要和子宫内队列的数据集，其中包括与国家切尔诺贝利登记处和白俄罗斯国家癌症登记处建立记录联系所获得的信息。我们还通过邮件调查更新主要队列受试者的生命状态和最后已知地址。