Essential Fatty Acids In Psychiatric Disorders

精神疾病中的必需脂肪酸

• 批准号: 10023072
• 负责人: Joseph Hibbeln
• 金额: $ 92.71万
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10023072
• 关键词: Addictive Behavior; Adolescence; Adult; Affective; Alcohol consumption; Alcohol or Other Drugs use; American; Analytical Chemistry; Anterior; Arachidonic Acids; Attention; Attention deficit hyperactivity disorder; Behavior; Biochemistry; Biological; Biological Assay; Birth; Blood; Blood specimen; Brain; Brazil; Bread; Cells; Characteristics; Child; Childhood; Clinical; Clinical Research; Clinical Trials; Communities; Complex; Conceptions; Conduct Disorder; Consumption; Corpus striatum structure; Coupled; Cross-Sectional Studies; Data; Depressed mood; Development; Diet; Dietary Component; Dietary Mercury; Dietary intake; Disadvantaged; Disease; Docosahexaenoic Acids; Dorsal; Emotional; Enrollment; Ensure; Environment; Environmental Risk Factor; Enzymes; Epidemiology; Essential Fatty Acids; European; Evaluation; Event; Fatty Acids; Fatty acid glycerol esters; Feeling suicidal; Fetus; Fishes; Follow-Up Studies; Food; Food Safety; Formulation; Foundations; Genes; Genetic; Goals; Health; Herbal Teas; Home environment; Human Milk; Impulsive Behavior; Impulsivity; Infant; Intake; Intervention; Lead; Life; Linear Regressions; Linoleic Acids; Longevity; Longitudinal Studies; Major Depressive Disorder; Mass Spectrum Analysis; Meat; Mediating; Mental Health; Mental disorders; Mercury; Meta-Analysis; Military Personnel; Mission; Modeling; Mothers; Motor; Nature; Nervous system structure; Neurobiology; Neurologic; Neurosciences; Neurotransmitters; Nutrient; Nutritional; Omega-3 Fatty Acids; Omega-6 Fatty Acids; Outcome; Oxidoreductase; Parents; Participant; Pathway interactions; Phenotype; Placebos; Plasma; Policies; Population; Postpartum Period; Pregnancy; Pregnant Women; Prevalence; Prevention strategy; Process; Production; Prospective cohort study; Protocols documentation; Public Policy; Publications; Randomized; Randomized Controlled Trials; Reaction; Recommendation; Reporting; Residual state; Rewards; Risk; Risk Factors; Schools; Scientist; Seafood; Series; Serum; Severities; Shellfish; Source; Substance abuse problem; Suicide; System; Techniques; Testing; Time; Tissues; Treatment Efficacy; Unsaturated Fatty Acids; Update; Variant; Veterans; Whole Blood; Wine; Woman; accomplished suicide; addiction; adrenic acid; alpha-Linolenic Acid; antepartum depression; base; career; clinical efficacy; clinical practice; cost effective; depressive symptoms; deviant; dietary guidelines; early pregnancy; emerging adult; fetal; financial incentive; genetic variant; grandparent; infancy; interest; member; mother nutrition; neonatal period; neurodevelopment; neuroimaging; novel; offspring; parental influence; peer; placebo group; pregnant; prenatal; prevent; randomized placebo controlled trial; resilience; response; restoration; single episode major depressive disorder; skills; sociodemographics; sound; study population; suicidal behavior; suicidal morbidity; suicidal risk; treatment strategy

The Mission of the Section on Nutritional Neurosciences is to increase the understanding of how nutrients, in particular essential fats, influence risks of addictions and aberrant behaviors so as to contribute to the rational development of effective prevention and treatment strategies across the life-span. To use neuroscience, analytical chemistry, epidemiology and genetics to inform causal evaluations, such as randomized controlled trials and applied clinical research, so as to provide sound data on which new public policies can be based. To maintain an intellectual environment that optimizes and integrates the skills of diverse scientists at all stages of their careers so as to come to a sophisticated understanding of complex processes underlying the neurobiology and nature of health and disease. To lead development of cost effective and acceptable foods that can be implemented to reduce risks of addictions, affective and impulsive disorders. To create effective interfaces with large-scale systems manifesting priority needs of efficient and stable implementation members of such systems include the US Military, disadvantaged public schools, vulnerable community populations and food producers. To use these practical implementations to evaluate clinical efficacy and feasibility. Clinical findings will subsequently inform novel questions in biochemistry and neuroscience. SNN pioneered the hypothesis that restoring adequate omega-3 HUFAs intakes could treat or prevent major depression. We systematically evaluated clinical trials evaluating treatment efficacy of n-3 HUFAs for depressed mood in a hierarchical meta-analysis. We sought to determine why some trials reported substantial clinical efficacy and others reported variable or no effects. We found that interventions using a formulation rich in EPA (>50% EPA) reported considerable clinical benefits (Hedges g = 0.34; p = 10-7), but formulation rich in DHA (>50% DHA) displayed no clinical benefits. Crucially, we found that when study enrolled participants with significant clinical depression, considerable benefits over placebo (Hedges g = 0.86; p = 10-8); in contrast to enrolling participants who did not have significant depressive symptoms. This analysis provides the foundation for treatment recommendations for major depressive symptoms. In previous publications we reported that lower intake of seafood and lower levels of DHA in breast milk were associated with markedly increased risks of depression during pregnancy and in the postpartum. Mothers selectively transfer DHA to their fetuses to support optimal neurological development during pregnancy. Without sufficient dietary intake, mothers can become depleted of DHA relative to n-6 HUFAs and may increase their risk of suffering major depressive symptoms and manifesting risk factors for suicide. Cross-sectional analyses were performed on data from 234 pregnant women enrolled in a prospective cohort study in Rio de Janeiro, Brazil. We found a higher likelihood of suicide risk was observed among women with higher arachidonic acid levels AA (20:4, n-6): OR=1.45, 95% CI 1.02-2.07 and adrenic acid levels AdA (22:4, n-6): OR=1.43, 95% CI 1.01-2.04. A higher likelihood of major depressive episode was also observed among women with higher AA levels OR=1.47, 95% CI 1.03-2.10 and AdA levels OR=1.59, 95% CI 1.09-2.32. Thus, higher serum levels of AA and AdA were associated with a greater likelihood of suicide risk and major depressive episode among pregnant Brazilian women. Many nutrients is seafood may have contributed to our prior finding that the 2004 FDA and EPA advisory for women to limit seafood consumption during pregnancy inadvertently creates greater risks of peer problems, poor prosocial behaviors and low verbal IQ. In order to interrogate the specific nutritional contribution of highly unsaturated omega-3 and omega-6 fats we previously utilized the Mendelian randomization of genetic variants is the FADS genes. The enzymes expressed by the FADS genes, delta 5 and delta 6 dehydrogenase, are rate limiting for the production of docosahexaenoic acid (DHA) and arachidonic acid (AA) from their precursors, alpha-linolenic acid (ALA) and linoleic acid (LA) respectively. We found 8 points lower IQ among children fed formula containing the precursor fatty acids who had the poor functioning variant, compared to formula fed children who had the functional FADS variant. We then interrogated maternal status and found that both poor functioning FADS variants and lower levels of maternal DHA and AA were associated with lower child IQ indicating a specific deficit of essential highly unsaturated fatty acids as one of the nutrients rich in fish. One goal has been to quantify the contribution of components of maternal diet to prenatal blood mercury level. Whole blood samples and information on diet and sociodemographic factors were col-lectedfrom pregnant women (n = 4,484) enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC). The blood samples were assayed for total mercury using inductively coupled plasma dynamic reaction cell mass spectrometry. Linear regression was used to estimate the relative contributions of 103 dietary variables and 6 sociodemographic characteristics to whole blood total mercury levels. We estimated that maternal diet accounted for 19.8% of the total variation in total blood mercury, with 44% of diet-associated variability (8.75% of the total variation) associated with seafood consumption (white fish, oily fish, and shellfish). Other dietary components positively associated with total blood mercury included wine and herbal teas, and components with significant negative associations included white bread, meat pies or pasties, and French fries. Thus although seafood is a source of dietary mercury, seafood appeared to explain a relatively small proportion of the variation in total blood mercury in our UK study population. Our findings suggest that limiting seafood intake during pregnancy may have a limited impact on prenatal blood mercury levels. In follow up studies, we specifically evaluated impacts and origins of maternal levels of mercury during early pregnancy (n = 4,484). We found that fish consumption explained only 7.*% of the variance in blood mercury levels. Among women who did not consume fish, higher blood levels of mercury were not predictive of offspring IQ. However, among women consuming fish, higher blood mercury levels were predictive of higher IQ among offspring. Development of an Exposome approach. Although there is considerable evidence to suggest that environmental factors are involved in the development of many childhood and adult outcomes, it is largely agreed that events or conditions in the prenatal or infant period may have a key effect on many pathways. Increasingly attention is being concentrated on even earlier time frames, with the possible influence of parental childhood, infancy and fetal life. The aim of an exposome analysis such as this is to identify previously unsuspected associations; the technique is thus both hypothesis testing and hypothesis generating. In this study we assessed 1,755 variables characterizing the grandparents, the parents birth, childhood, adolescence and early adulthood, the environment prior to conception, during pregnancy, labor, delivery, and the neonatal period. The outcome variable was the childs motor ability as demonstrated using a test of ball skills. In this study one of the major findings concerned the mothers traumatic childhood. The unadjusted analyses showed that the offspring of mothers who had been abused physically or emotionally, those who had rated their own mothers as uncaring and/or unstable, and who had spent some time in a Childrens Home were more likely to have offspring with poor ball skills.

营养神经科学科的任务是增进对营养素，特别是必需脂肪如何影响成瘾和异常行为风险的了解，从而有助于在整个生命周期中合理制定有效的预防和治疗战略。利用神经科学、分析化学、流行病学和遗传学为因果评估提供信息，例如随机对照试验和应用临床研究，从而为新的公共政策提供可靠的数据基础。维持一个智力环境，优化和整合不同科学家在其职业生涯的各个阶段的技能，以便对潜在的神经生物学和健康与疾病的本质的复杂过程有一个复杂的理解。领导开发具有成本效益和可接受的食品，以减少成瘾、情感和冲动障碍的风险。为了与大规模系统建立有效的接口，显示出高效和稳定的优先需求，这些系统的实施成员包括美国军方、弱势公立学校、弱势社区人口和食品生产商。用这些实际实施方法评价临床疗效和可行性。临床研究结果随后将为生物化学和神经科学的新问题提供信息。