A Prospective Investigation of Youth Alcohol Experimentation and Reward Responsivity

青少年酒精实验和奖励反应的前瞻性调查

• 批准号: 10001410
• 负责人: April Chelsea May
• 金额: $ 3.84万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2021-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10001410
• 关键词: 10 year old; 12 year old; Adolescence; Adolescent; Adult; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Behavior; Behavioral; Brain; Brain region; Child; Childhood; Cognitive; Corpus striatum structure; Coupled; Data; Data Set; Development; Early Intervention; Foundations; Frequencies; Future; Goals; Health Policy; Individual Differences; Investigation; Knowledge; Life; Link; Mental disorders; Modeling; Nucleus Accumbens; Pattern; Prefrontal Cortex; Preventive Intervention; Public Health; Reporting; Rewards; Risk; Risk Factors; Risk-Taking; Role; School-Age Population; Substance Use Disorder; System; Time; United States; Youth; adolescent substance use; aged; alcohol exposure; alcohol reward; alcohol use disorder; behavior measurement; brain circuitry; cognitive development; connectome; drinking; drinking behavior; early alcohol use; early experience; early onset substance use; financial incentive; follow-up; high risk drinking; improved; indexing; neural network; neurodevelopment; prospective; psychosocial; relating to nervous system; reward processing; screening; sixth grade; substance misuse; young adult

PROJECT SUMMARY/ABSTRACT Adolescence is a period of considerable neural development marked by cognitive and behavioral changes including increased engagement in novelty-seeking and risk-taking behaviors (e.g., substance use experimentation). Approximately 8% of youth in the United States report having used alcohol by the end of 6th grade. Early substance use initiation is linked to increased risk of substance use and other psychiatric disorders as well as greater psychosocial difficulties by adulthood. According to the imbalance model of adolescent neural development, increased risk-taking is due to different developmental patterns between frontal and striatal regions of the brain. This imbalance results in a weaker inhibitory control system coupled with a more mature striatal reward-processing system during adolescence. Altered patterns of functional neural connectivity between frontal and striatal regions have been observed prior to substance use initiation, and may serve as a predisposing vulnerability factor for development of substance use disorder. However, this potential marker has yet to be examined prospectively, prior to adolescence, in youth who endorse early but minimal exposure to alcohol (sipping). The goal of the proposed study is to examine reward-related fcMRI prospectively as a predictor of future substance use in youth aged 9-10 years old who endorse early but minimal exposure to alcohol (i.e., sipping). To examine this question, data gathered from approximately 11,500 youth as part of the ABCD consortium will be used. Alcohol and substance use and reward-related functional connectivity will be examined at baseline (youth ages 9-10 years old) and 2 years later (11-12 years old). Ultimately, the knowledge gained from this project can be used to inform public health policies to promote prevention and early intervention.

项目总结/文摘