Mentoring and neuroimaging research on new targets for DBS in OCD

强迫症 DBS 新目标的指导和神经影像学研究

• 批准号: 10001008
• 负责人: NIKOLAOS MAKRIS
• 金额: $ 16.34万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-18 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10001008
• 关键词: Affect; Aging; Anatomy; Animals; Anterior; Appointment; Autopsy; Award; Behavioral; Biological; Biological Markers; Brain; Brain Pathology; Brain Stem; Clinic; Clinical; Clinical Medicine; Clinical Research; Clinical Trials; Collaborations; Complex; Corpus striatum structure; Data; Data Analyses; Deep Brain Stimulation; Development; Diagnosis; Diffusion; Fiber; Foundations; Functional disorder; Funding; General Hospitals; Generations; Goals; Grant; Head; Hospitals; Human; Image; Implant; Individual; Investigation; Laboratories; Lesion; Link; Lobotomies; Macaca mulatta; Magnetic Resonance Imaging; Maps; Massachusetts; Measures; Medical; Mental disorders; Mentors; Mentorship; Metabolic; Methods; Modernization; Monitor; Myelin; National Institute of Mental Health; Nature; Neurobiology; Neurology; Neurosciences; Neurosurgical Procedures; Obsessive-Compulsive Disorder; Operative Surgical Procedures; Outcome; Parents; Patients; Pharmaceutical Preparations; Play; Population; Positron-Emission Tomography; Postdoctoral Fellow; Postoperative Period; Probability; Prospective Studies; Protocols documentation; Psychiatrist; Psychiatry; Radiology Specialty; Research; Research Personnel; Research Support; Research Training; Residual state; Resistance; Resolution; Rest; Retrospective cohort; Role; Scientist; Senior Scientist; Shapes; Solid; Structure; Symptoms; Talents; Testing; Thalamic structure; Time; Tissues; Training; Translating; United States National Institutes of Health; Validation; Ventral Striatum; Woman; Work; base; capsule; career; career development; cingulate cortex; cingulotomy; connectome; electric field; experience; fluorodeoxyglucose positron emission tomography; glucose metabolism; graduate student; gray matter; improved outcome; in vivo; individual patient; medical schools; mid-career faculty; multimodality; neural circuit; neuroimaging; neuroimaging marker; neuroinflammation; neuropsychiatric disorder; patient oriented; programs; response; skills; standard of care; success; summer student; tool; tractography; treatment strategy; undergraduate student; white matter; white matter change

Abstract I am a clinical psychiatrist by training, and neuroscientist. I have devoted my research career to understanding mechanisms, nature and time-course of intractable psychiatric illnesses, such as obsessive compulsive disorder (OCD). I am an Associate Professor in the Departments of Psychiatry and Neurology at Massachusetts General Hospital (MGH), Harvard Medical School. I serve as Director of the Center for Morphometric Analysis, Department of Psychiatry at MGH, and as Director of Computational Imaging Anatomy at the Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham & Women’s Hospital (BWH), where I hold secondary appointments, at Psychiatry and Radiology, as a research scientist. I have been conducting NIH sponsored research since 2003, when I received my first R03 award. I am currently a PI on two NIH grants (R01, funded by NIA & NIMH; R21 funded by NCCIH) focused on understanding mechanisms of brain development, maturation and aging through a set of neuroimaging tools and their validation in rhesus monkeys. Those two grants together have the potential of delivering validated neuroimaging biomarkers, which could be used to diagnose and monitor neurobiological changes due to myelin loss and neuroinflammation in aging, and a whole list of other neuropsychiatric diseases where those changes are involved. Furthermore, I’m a PI in a new grant (R01MH111917), which specifically focuses on retrospective investigation of imaging- based targeting for DBS in OCD and serves as the scientific basis upon which this K24 application is hoping to extend in depth and scope. Besides my research, I am also involved in mentoring Harvard, MIT and BU undergraduate and graduate students, postdoctoral fellows (including K23 awardees), foreign fellows, and summer students. I am also involved in administrative work, as head of two large laboratories, at MGH and at BWH, and various local and regional committees. Finally, I am getting involved in nonclinical and non-POR research (through my ongoing and pending animal projects), and that takes away from both my mentoring and my POR research. The K24 would protect time and help me to focus on most important for my career development- mentoring (30%), further training and new POR (20%), while devoting remaining 50% to ongoing neuroimaging research in biomarkers of white matter changes in aging and OCD.

摘要 我是一名受过训练的临床精神病学家，也是一名神经学家。我的研究生涯致力于了解 机制，性质和时间进程的顽固性精神疾病，如强迫症， 强迫症（OCD）我是精神病学和神经病学系的副教授， 马萨诸塞州总医院（MGH），哈佛医学院。我担任中心主任， MGH精神病学系形态测量分析，并担任计算成像解剖学主任 精神病学神经影像实验室，精神病学系，布里格姆妇女医院（BWH）， 我在那里担任精神病学和放射学的第二职位，作为一名研究科学家。我一直在 自2003年以来，我一直在进行NIH赞助的研究，当时我获得了第一个R 03奖。我目前是一名PI， 两项NIH赠款（R 01，由NIA和NIMH资助; R21由NCCIH资助）侧重于理解机制 通过一套神经成像工具及其在恒河猴中的验证， 猴子这两项赠款共同具有提供经验证的神经成像生物标志物的潜力， 可用于诊断和监测由于髓鞘丢失和神经炎症引起的神经生物学变化， 衰老，以及一系列与这些变化有关的其他神经精神疾病。而且我也 一项新资助（R 01 MH 111917）中的PI，专门关注成像的回顾性研究- 基于DBS在强迫症中的靶向，并作为K24应用的科学基础， 在深度和广度上延伸。除了我的研究之外，我还参与指导哈佛、麻省理工学院和波士顿大学 本科生和研究生，博士后研究员（包括K23获奖者），外国研究员，以及 暑期学生我还参与行政工作，作为两个大型实验室的负责人，在MGH和 BWH，以及各种地方和区域委员会。最后，我参与了非临床和非POR 研究（通过我正在进行的和悬而未决的动物项目），这带走了我的指导和 我的POR研究K24将保护时间，帮助我专注于对我的职业生涯最重要的事情 发展-辅导（30%），进一步培训和新的POR（20%），同时将剩余的50%用于持续的 衰老和强迫症中白色物质变化生物标志物的神经影像学研究。