Mentoring and neuroimaging research on new targets for DBS in OCD

摘要 我是一名训练有素的临床精神病学家，也是一名神经学家。我把我的研究生涯奉献给了理解 强迫症等难治性精神疾病的机制、性质和时间进程 精神障碍(OCD)。我是纽约大学精神病学和神经病学系的副教授 麻省总医院(MGH)，哈佛医学院。我担任该中心的主任 形态测量分析，麻省理工学院精神病学系，计算成像解剖学主任 在布里格姆妇女医院精神病科精神病学神经成像实验室， 在那里，我作为研究科学家在精神病学和放射学担任次要职务。我一直在 自2003年我第一次获得R03奖以来，我一直在进行NIH赞助的研究。我目前是一名私家侦探 NIH的两笔赠款(R01，由NIA和NIMH资助；R21由NCCIH资助)侧重于了解机制 通过一套神经成像工具对恒河猴脑发育、成熟和衰老的研究及其有效性 猴子。这两笔赠款加在一起有可能提供经过验证的神经成像生物标记物， 可用于诊断和监测由髓鞘丢失和神经炎症引起的神经生物学变化 衰老，以及涉及这些变化的其他神经精神疾病的完整清单。再者，我是 新拨款中的私人投资(R01MH111917)，特别侧重于对成像的回顾调查- 以强迫症中的DBS为目标，并作为K24应用程序希望的科学基础 在深度和广度上延伸。除了我的研究，我还参与了哈佛、麻省理工学院和波士顿大学的指导工作 本科生和研究生、博士后研究员(包括K23获奖者)、外国研究员和 暑期班的学生。我还参与了行政工作，作为两个大型实验室的负责人，分别在MGH和 BWH，以及各种地方和区域委员会。最后，我将参与非临床和非POR 研究(通过我正在进行的和即将进行的动物项目)，这让我失去了指导和 我的战俘研究。K24将保护时间，帮助我专注于对我的职业生涯最重要的事情 发展-指导(30%)、进一步培训和新的POR(20%)，其余50%用于持续 衰老和强迫症脑白质变化生物标志物的神经影像研究。

Abstract I am a clinical psychiatrist by training, and neuroscientist. I have devoted my research career to understanding mechanisms, nature and time-course of intractable psychiatric illnesses, such as obsessive compulsive disorder (OCD). I am an Associate Professor in the Departments of Psychiatry and Neurology at Massachusetts General Hospital (MGH), Harvard Medical School. I serve as Director of the Center for Morphometric Analysis, Department of Psychiatry at MGH, and as Director of Computational Imaging Anatomy at the Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham & Women’s Hospital (BWH), where I hold secondary appointments, at Psychiatry and Radiology, as a research scientist. I have been conducting NIH sponsored research since 2003, when I received my first R03 award. I am currently a PI on two NIH grants (R01, funded by NIA & NIMH; R21 funded by NCCIH) focused on understanding mechanisms of brain development, maturation and aging through a set of neuroimaging tools and their validation in rhesus monkeys. Those two grants together have the potential of delivering validated neuroimaging biomarkers, which could be used to diagnose and monitor neurobiological changes due to myelin loss and neuroinflammation in aging, and a whole list of other neuropsychiatric diseases where those changes are involved. Furthermore, I’m a PI in a new grant (R01MH111917), which specifically focuses on retrospective investigation of imaging- based targeting for DBS in OCD and serves as the scientific basis upon which this K24 application is hoping to extend in depth and scope. Besides my research, I am also involved in mentoring Harvard, MIT and BU undergraduate and graduate students, postdoctoral fellows (including K23 awardees), foreign fellows, and summer students. I am also involved in administrative work, as head of two large laboratories, at MGH and at BWH, and various local and regional committees. Finally, I am getting involved in nonclinical and non-POR research (through my ongoing and pending animal projects), and that takes away from both my mentoring and my POR research. The K24 would protect time and help me to focus on most important for my career development- mentoring (30%), further training and new POR (20%), while devoting remaining 50% to ongoing neuroimaging research in biomarkers of white matter changes in aging and OCD.