Unraveling the superficial white matter of the primate brain: Tracer-based histology and dMRI tractography validation

解开灵长类动物大脑的浅层白质:基于示踪剂的组织学和 dMRI 纤维束成像验证

基本信息

  • 批准号:
    10521896
  • 负责人:
  • 金额:
    $ 70.74万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-07-01 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

Abstract In this 5 year R01 grant entitled “Unraveling the superficial white matter of the primate brain: Tracer-based histology and diffusion MRI tractography validation,” we will map superficial white matter (SWM) in the primate cerebrum using experimental tract tracing methods. We will use this ground truth information to validate high- resolution in vivo and ultra-high resolution ex vivo diffusion MRI (dMRI) based tractography in the same rhesus macaque monkeys. The SWM is a continuous layer located between the cerebral cortex of the forebrain and the underlying white matter association pathways. It comprises axons that interconnect cerebral cortical areas, including U-shaped fibers (U-fibers) under the cerebral sulci. This axonal layer plays a role in a broad range of neurological conditions such as autism spectrum disorder, multiple sclerosis, and Alzheimer’s disease, and knowledge of the SWM is essential for accurately interpreting dMRI-based tractography. Critically, the fundamental connectional neuroanatomy of the SWM is largely unknown due to our inability to visualize the specific origins, terminations, and trajectories of axons in the human brain. Our knowledge of human SWM connectional neuroanatomy is thus derived almost exclusively from experimental tract tracing results in the non- human primate (NHP) model, but comprehensive studies of the NHP SWM, from origin through trajectory to termination, have not been performed. Therefore, knowledge of human SWM connectivity and organization can be improved by invasive tract tracing studies in the NHP. The goal of the proposed research is to carry out the first detailed neuroanatomical study of the SWM in the NHP brain, with dMRI validation in the NHP and translation to human brains. To achieve this goal, we will use a range of histological techniques in conjunction with dMRI scans obtained with the Massachusetts General Hospital (MGH) Connectom scanner to produce superior quality dMRI data. We will first datamine the research literature to produce a compendium of existing knowledge of SWM connectivity in the rhesus monkey. We will also examine the Pandya-Rosene Archive, a vast collection of neuroanatomy cases that has formed the foundation of data on white matter connections in the NHP. We will utilize this archive to chart the organization of the SWM in frontal brain areas. We will then use modern histological methods, including CLARITY-based tissue clearing and neuroanatomical tract tracing, to interrogate the structure, topography, and connectivity of the SWM, and thereby produce ground truth data. We will perform in vivo and ex vivo dMRI in the same animals in which we perform neuroanatomical tract tracing experiments, allowing for direct comparisons between histological and neuroimaging-based connectivity. Moreover, we will disseminate the dMRI data to the neuroimaging community and host a competition to determine the optimal tractography method for SWM. Finally, we will translate knowledge of SWM neuroanatomy to the human brain using homologically based comparisons with Human Connectome Project datasets. These data will provide ground truth of SWM connectivity and serve to improve dMRI tractography in NHP and human brains.
摘要

项目成果

期刊论文数量(0)
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专利数量(0)

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NIKOLAOS MAKRIS其他文献

NIKOLAOS MAKRIS的其他文献

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{{ truncateString('NIKOLAOS MAKRIS', 18)}}的其他基金

Unraveling the Superficial White Matter of the Primate Brain: Tracer-Based Histology and dMRI Tractography Validation
解开灵长类动物大脑的浅表白质:基于示踪剂的组织学和 dMRI 纤维束成像验证
  • 批准号:
    10650392
  • 财政年份:
    2022
  • 资助金额:
    $ 70.74万
  • 项目类别:
Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRI
使用超高分辨率多重对比扩散 MRI 绘制人脑浅层白质连接组图
  • 批准号:
    10623234
  • 财政年份:
    2021
  • 资助金额:
    $ 70.74万
  • 项目类别:
Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRI
使用超高分辨率多重对比扩散 MRI 绘制人脑浅层白质连接组图
  • 批准号:
    10441330
  • 财政年份:
    2021
  • 资助金额:
    $ 70.74万
  • 项目类别:
Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRI
使用超高分辨率多重对比扩散 MRI 绘制人脑浅层白质连接组图
  • 批准号:
    10182286
  • 财政年份:
    2021
  • 资助金额:
    $ 70.74万
  • 项目类别:
Mentoring and neuroimaging research on new targets for DBS in OCD
强迫症 DBS 新目标的指导和神经影像学研究
  • 批准号:
    10228734
  • 财政年份:
    2018
  • 资助金额:
    $ 70.74万
  • 项目类别:
Mentoring and neuroimaging research on new targets for DBS in OCD
强迫症 DBS 新目标的指导和神经影像学研究
  • 批准号:
    10456322
  • 财政年份:
    2018
  • 资助金额:
    $ 70.74万
  • 项目类别:
Mentoring and neuroimaging research on new targets for DBS in OCD
强迫症 DBS 新目标的指导和神经影像学研究
  • 批准号:
    10001008
  • 财政年份:
    2018
  • 资助金额:
    $ 70.74万
  • 项目类别:
Identification and Validation of Human Hypothalamic Nuclei in-vivo and ex-vivo Us
体内和离体人类下丘脑核团的鉴定和验证
  • 批准号:
    7891395
  • 财政年份:
    2009
  • 资助金额:
    $ 70.74万
  • 项目类别:
Identification and Validation of Human Hypothalamic Nuclei in-vivo and ex-vivo Us
体内和离体人类下丘脑核团的鉴定和验证
  • 批准号:
    7739404
  • 财政年份:
    2009
  • 资助金额:
    $ 70.74万
  • 项目类别:
Core 2
核心2
  • 批准号:
    7501657
  • 财政年份:
    2007
  • 资助金额:
    $ 70.74万
  • 项目类别:

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