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Colorado Mycobacteria Conference: Focus on NTM

科罗拉多分枝杆菌会议：聚焦 NTM

基本信息

批准号：
10001954
负责人：
DEAN C CRICK
金额：
$ 1.2万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10001954
关键词：
Antibiotic Resistance Area Atmosphere Bacteria Biology Bronchiectasis Chronic Obstructive Airway Disease Collaborations Colorado Communities Complex Cystic Fibrosis Development Diagnostic Disease Domestic Animals Ecology Epidemiology Etiology Event Fostering Genus Mycobacterium Goals Health Immune response Immunology Incidence Individual Infection Infection Control International Lead Lung Lung diseases Lung infections Maps Mycobacterium Infections Mycobacterium abscessus Mycobacterium avium Complex Mycobacterium tuberculosis National Institute of Allergy and Infectious Disease Oral Organism Outcome Participant Pathology Population Prevalence Public Health Publishing Reporting Research Research Personnel Resistance Resources Risk Scientist Senior Scientist Skin Tissue Social Interaction Soft Tissue Infections Soil Source Therapeutic Training Translational Research Tuberculosis United States Update Vaccines Virulence Water Wild Animals antimicrobial base career career networking cystic fibrosis patients disorder prevention genome sequencing innovation interdisciplinary approach interest member next generation non-tuberculosis mycobacteria posters social soft tissue symposium tool treatment strategy whole genome

项目摘要

Abstract Non-tuberculous mycobacteria (NTM) comprise a large, diverse group of bacteria usually found in soil, water and wild and domestic animal populations. NTM were not recognized as significant sources of pulmonary disease until relatively recently. Unlike Mycobacterium tuberculosis, NTM do not cause tuberculosis (TB), but can cause skin and soft tissue infections, disseminated infections and severe lung disease, and pose a particular threat for those afflicted with cystic fibrosis, chronic obstructive pulmonary disease (COPD) or pre-existing bronchiectasis. There is currently no vaccine to protect from NTM infections. NTM are also intrinsically resistant to most existing antimicrobials. Among new antimicrobials currently under various stages of development, including those to treat TB, few have potent anti-NTM activity. Multiple studies indicate that the prevalence of NTM disease is increasing globally. The incidence and prevalence of NTM lung disease (NTM-LD) in the U.S. is also increasing, and now surpasses that of TB. However, we have a fundamentally poor understanding of NTM and the diseases they cause. The goals of the Colorado Mycobacteria Conference: Focus on NTM are to help fill the existing gaps in basic and translational NTM research by bringing together junior and senior scientists, clinicians and public health officials that do not often attend the same conferences, highlighting new findings, discussing lessons learned and, importantly, training the next generations of researchers and clinicians.

摘要非结核分枝杆菌（NTM）包括通常在土壤中发现的大量不同的细菌，水和野生及家养动物种群。NTM未被视为重要来源肺部疾病，直到最近。与结核分枝杆菌不同，NTM不会引起结核病（TB），但可引起皮肤和软组织感染，播散性感染和严重的肺部感染疾病，并对那些患有囊性纤维化，慢性阻塞性肺疾病，疾病（COPD）或既存支气管扩张。目前还没有疫苗可以预防NTM感染。 NTM本身也对大多数现有的抗菌剂具有耐药性。在目前正在开发的新抗菌剂中，在不同的发展阶段，包括那些治疗结核病，很少有有效的抗NTM活性。多项研究表明NTM疾病的患病率在全球范围内正在增加。NTM肺的发病率和患病率在美国，NTM-LD的发病率也在增加，现在已经超过了TB。然而，我们有一个对NTM及其引起的疾病的基本认识不足。科罗拉多队的目标是分枝杆菌会议：关注NTM有助于填补基础和翻译NTM的现有空白通过汇集初级和高级科学家，临床医生和公共卫生官员，参加同样的会议，强调新的调查结果，讨论吸取的教训，重要的是，培训下一代的研究人员和临床医生。