Colorado Mycobacteria Conference: Focus on NTM

摘要 非结核分枝杆菌（NTM）包括通常在土壤中发现的大量不同的细菌， 水和野生及家养动物种群。NTM不被认为是 肺部疾病，直到最近。与结核分枝杆菌不同，NTM不会引起 结核病（TB），但可引起皮肤和软组织感染，播散性感染和严重的肺部感染 疾病，并对那些患有囊性纤维化，慢性阻塞性肺疾病， 疾病（COPD）或既存支气管扩张。目前还没有疫苗可以预防NTM感染。 NTM本身也对大多数现有的抗菌剂具有耐药性。在目前正在开发的新抗菌剂中， 在不同的发展阶段，包括那些治疗结核病，很少有有效的抗NTM活性。多项研究 表明NTM疾病的患病率在全球范围内正在增加。NTM肺的发病率和患病率 美国的NTM-LD也在增加，现在超过了结核病。然而，我们有一个 对NTM及其引起的疾病的基本认识不足。科罗拉多队的目标是 分枝杆菌会议：关注NTM有助于填补基础和翻译NTM的现有空白 通过汇集初级和高级科学家，临床医生和公共卫生官员， 参加同样的会议，强调新的调查结果，讨论吸取的教训，重要的是，培训 下一代的研究人员和临床医生。

Abstract Non-tuberculous mycobacteria (NTM) comprise a large, diverse group of bacteria usually found in soil, water and wild and domestic animal populations. NTM were not recognized as significant sources of pulmonary disease until relatively recently. Unlike Mycobacterium tuberculosis, NTM do not cause tuberculosis (TB), but can cause skin and soft tissue infections, disseminated infections and severe lung disease, and pose a particular threat for those afflicted with cystic fibrosis, chronic obstructive pulmonary disease (COPD) or pre-existing bronchiectasis. There is currently no vaccine to protect from NTM infections. NTM are also intrinsically resistant to most existing antimicrobials. Among new antimicrobials currently under various stages of development, including those to treat TB, few have potent anti-NTM activity. Multiple studies indicate that the prevalence of NTM disease is increasing globally. The incidence and prevalence of NTM lung disease (NTM-LD) in the U.S. is also increasing, and now surpasses that of TB. However, we have a fundamentally poor understanding of NTM and the diseases they cause. The goals of the Colorado Mycobacteria Conference: Focus on NTM are to help fill the existing gaps in basic and translational NTM research by bringing together junior and senior scientists, clinicians and public health officials that do not often attend the same conferences, highlighting new findings, discussing lessons learned and, importantly, training the next generations of researchers and clinicians.