The effect of poverty, stress and immune function on health across the life-course

摘要 该项目将评估一项大规模的国家反贫困方案对疾病的中期影响， 成年人（45岁以上）和年轻人（20-26岁）的健康风险。我们建立在一个纵向随机 对照试验，旨在评估无条件现金转移计划在低收入环境中的影响。 关于研究人群的第四波数据将包括免疫反应，疾病风险， 和认知能力。结合这些措施与信息，从以前的波，包括前， 干预期，将使我们能够绘制出生物，行为和经济途径，通过这些途径， 现金转移方案在生命周期的两个阶段影响健康。 具体来说，我们将利用随机分配到早期进入引起的收入的外生变化 治疗条件，以估计收入贫困对免疫功能的因果影响，以及压力的作用 调解这段关系我们还将估计现金转移对一系列 疾病风险指标。在我们的样本中，有一半的年轻人在他们的职业生涯中接触过现金转移。 关键的青春期，使我们能够估计现金对他们疾病风险的影响。通过提供 对于成年人和年轻人的估计，我们可以观察假设的关系是否不同， 穿越生命历程该提案涉及国家老龄问题研究所的目标B，即“更好地了解 个人、人际和社会因素对老龄化的影响，包括 这些因素发挥了作用。“在目标B中，该提案响应了目标B1：”指明道路 社会、心理、经济和行为因素影响中老年人的健康。'

Abstract This project will assess the medium-term impact of a large-scale national anti-poverty program on disease and health risk of mature adults (age 45+) and young adults (age 20-26). We build on a longitudinal randomized control trial designed to evaluate the impact of an unconditional cash transfer program in a low-income setting. A fourth wave of data on the study population will include new measures of immune response, disease risk, and cognitive capacity. Combing these measures with information from previous waves, including the pre- intervention period, will allow us to map out the biological, behavioral and economic pathways through which a cash transfer program influences health at two points in the life-cycle. Specifically, we will exploit the exogenous change in income evoked by random assignment to early-entry treatment condition to estimate the causal effect of income poverty on immune function, and the role of stress in mediating this relationship. We will also estimate the causal effect of the cash transfer on a range of indicators of disease risk. Half the young adults in our sample were exposed to the cash transfer during their critical adolescence years, allowing us to estimate the impact of the cash on their disease risk. By providing estimates for both mature and younger adults, we can observe whether the hypothesized relationship vary across the life-course. The proposal addresses the National Institute of Ageing's Goal B to `better understand the effects of personal, interpersonal, and societal factors on ageing, including mechanisms through which these factors exert their effects.' Within Goal B, the proposal responds to objective B1: `Illuminate the pathways by which social, psychological, economic, and behavioral factors affect health in middle-aged and older adults.'