Core B: Small Animal Radiation Core

核心B：小动物辐射核心

• 批准号: 10005187
• 负责人: Constantinos Koumenis
• 金额: $ 18.39万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005187
• 关键词: Address; Affect; Animal Housing; Animal Model; Animals; Area; Back; Blood; Body Temperature; Breeding; Center for Translational Science Activities; Clinical; Clinical Oncology; Collection; Dose; Ecosystem; Elevator; Ensure; Experimental Neoplasms; Exposure to; Goals; Grant; Housing; Human Resources; Image; Immune response; Immune system; Immunotherapy; Implant; Institution; Investigation; Knowledge; Malignant Neoplasms; Modality; Modeling; Monitor; Movement; Mus; Normal tissue morphology; Patients; Photons; Physics; Procedures; Process; Proton Radiation; Protons; Quality Control; Radiation; Radiation Dose Unit; Radiation Oncology; Radiation therapy; Radioimmunotherapy; Regulation; Reproducibility of Results; Research; Research Personnel; Robotics; Role; Running; Schedule; Scheme; Schools; Services; Standardization; Supervision; System; Systems Analysis; Temperature; Tissue Harvesting; Tissues; Transplantation; Tumor Tissue; Variant; Washington; animal facility; base; cone-beam computed tomography; cost efficient; design; dosimetry; experience; experimental study; image-guided radiation; immune checkpoint blockade; innovation; instrument; irradiation; microbiome; operation; pancreatic cancer model; pathogen; programs; proton beam; proton therapy; radiation delivery; radiation response; response; treatment delivery technique; treatment planning; tumor; tumor-immune system interactions

PROJECT SUMMARY The overall goal of the Small Animal Radiation Core (SARC) is to provide “turn-key” animal housing and photon and proton radiation (including image-guided radiation) to tumors implanted into syngeneic mice as well as spontaneous, autocthonous tumors. Moreover, it will furnish accurate dosimetry and quality control necessary for successful completion of the studies proposed in Projects 2 and 3. A key feature of this Core is the centralization and standardization of services intended to minimize inter-animal variability in terms of immune system regulation and tumor response to radiation. We have devised a streamlined process for movement of animals from ordering (C57/Bl6) or procuring them from breeding (KPC pancreatic tumor model) to tumor radiation and back to housing until the animals are euthanized and tumors and tissues are harvested. At the center of this Core is a dedicated animal holding facility and a brand new renovated animal treatment room which will house and already available and established Small Animal Radiation Research Platform (SARRP) instrument from X-Strahl, Inc as well as dedicated proton Beam available in the Smilow Center for Translational Research (SCTR). The three main aims of this core are: Aim 1: To establish a dedicated housing suite with controlled environmental parameters. Aim 2: To deliver both Photon and Proton-based irradiation to mouse tumors in a conformal manner using the Small Animal Radiaiton Platform (SARRP) and available Proton Beam thereby avoiding radiation of normal tissues as much as possible. Aim 3: To develop precise dosimetry and quality-control analysis systems to ensure the prescribed dose was delivered to the target. The two co-Directors, Drs. Koumenis and Solberg, bring considerable expertise in small animal radiation as well as managing radiation facilities both at Penn and prior Institutions. Successful implementation of these services will provide the Project Leaders seamless and uniform treatment modalities and has the potential to serve as a model facility for other similar research efforts world-wide.

项目摘要 小动物辐射中心（SARC）的总体目标是提供“交钥匙”动物 外壳以及对植入肿瘤的光子和质子辐射（包括图像引导辐射） 同系小鼠以及自发的自体肿瘤。此外，它将提供 成功完成研究所需的准确剂量测定和质量控制 在项目2和3中提出。该核心的一个关键特征是集中化， 服务标准化，旨在最大限度地减少动物间免疫差异 系统调节和肿瘤对辐射的反应。我们设计了一个简化的流程， 动物从订购（C57/B16）或从繁殖（KPC胰腺）中获得动物的运动 肿瘤模型）进行肿瘤辐射并返回圈养直至动物被安乐死， 收获肿瘤和组织。在这个核心的中心是一个专门的动物收容所， 设施和一个全新装修的动物治疗室， 小动物辐射研究平台（SARRP） X-Strahl，Inc以及Smilow转化中心提供的专用质子束 研究（SCTR）。该核心的三个主要目标是：目标1：建立一个专门的 控制环境参数的住房套房。目标2：提供光子和 使用Small Animal以适形方式对小鼠肿瘤进行基于质子的照射 辐射平台（SARRP）和可用的质子束，从而避免正常辐射 尽可能多的组织。目的3：发展精确的剂量学和质量控制分析 系统，以确保处方剂量输送到目标。两名董事，博士。 Koumenis和Solberg，带来了相当多的专业知识，在小动物辐射以及 管理宾夕法尼亚大学和之前机构的辐射设施。成功实施 这些服务将为项目负责人提供无缝和统一的治疗模式， 有可能成为世界各地其他类似研究工作的示范设施。