Neurocircuitry of Prospective Memory in Veterans with Mild Traumatic Brain Injury

轻度脑外伤退伍军人未来记忆的神经回路

• 批准号: 10039498
• 负责人: Scott Francis Sorg
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10039498
• 关键词: Afghanistan; Anterior; Applications Grants; Appointment; Attention; Award; Biological; Biological Markers; Biometry; Brain; Caring; Clinical; Cognition; Cognitive; Collaborations; Craniocerebral Trauma; Data; Development; Diagnostic; Diffusion Magnetic Resonance Imaging; Dose; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Glean; Goals; HIV; Healthcare Systems; Impaired cognition; Impairment; Inferior; Injury; Intervention; Iraq; K-Series Research Career Programs; Lateral; Learning; MRI Scans; Manuscripts; Marshal; Measures; Mediating; Memory; Memory impairment; Mentorship; Modality; Neurocognitive; Neuropsychological Tests; Neuropsychology; Outcome; Parietal Lobe; Participant; Pathway interactions; Patients; Performance; Pharmaceutical Preparations; Postdoctoral Fellow; Prefrontal Cortex; Procedures; Prospective Studies; Publishing; Questionnaires; Recording of previous events; Reporting; Research; Research Methodology; Research Personnel; Research Training; Resources; Sampling; Scientist; Structure; Task Performances; Techniques; Testing; Time; Training; Veterans; Work; base; blast exposure; career; cingulate cortex; cognitive control; cognitive function; cognitive process; cognitive rehabilitation; cohort; combat veteran; daily functioning; executive function; experience; forgetting; frontal lobe; imaging modality; improved; interest; medical appointment; mild traumatic brain injury; multidisciplinary; multimodality; neural circuit; neural network; neuroimaging; patient oriented; prospective memory; prospective test; recruit; relating to nervous system; research study; treatment response; white matter; white matter damage

Rates of mild traumatic brain injury (mTBI) are high among combat veterans, with reports suggesting 10-20% of Iraq and Afghanistan Veterans meet diagnostic criteria for mTBI, the vast majority of which being related to explosive blasts. There is on-going debate as to whether blast-related mTBI may result in long-term neuropsychological impairment, given the paucity of positive findings, despite on-going complaints of cognitive difficulties within this cohort. One possible explanation for this discrepancy is that traditional neuropsychological test procedures may lack sensitivity in capturing subtle deficits in everyday functioning in blast-related mTBI. Prospective memory (PM) is the ability to remember to execute an action at a certain point in the future, or is the fulfillment of delayed intentions. PM may be more sensitive to the functional difficulties described by some Veterans with mTBI (e.g., forgetting appointments) than those domains typically assessed (e.g., executive functions, attention and retrospective memory). Results of functional neuroimaging studies suggest that PM is dependent on a frontally-guided cortical network comprised of the anterior prefrontal cortex, dorsolateral prefrontal cortex, the anterior cingulate and parietal cortex. Neurostructural damage to the white matter pathways that integrate this network presents a possible underlying mechanism for PM disruption in mTBI. To date, few studies have investigated the effect of mTBI on PM, and no published studies have investigated the neurocircuitry of PM in OEF/OIF Veterans with a history of blast-related mTBI. The proposed study aims to utilize neuropsychological assessment and an integrated multi-modal neuroimaging analysis to study prospective memory (PM) functioning in Veterans with histories of blast-related mTBI. Eighty participants will be recruited from within an existing VA-funded TBI research study and will include Veterans with a history of blast-related mTBI (n = 40) or deployed Veterans without a history of mTBI (n = 40). Participants will complete a broad neurocognitive assessment which includes PM questionnaires and objective measures of PM. Veterans will also undergo an MRI scan which includes diffusion tensor imaging (DTI) and completion of a PM fMRI task. The study aims are to investigate PM performance in Veterans with histories of blast-related mTBI, investigate the neural network associated with PM functions via integration of fMRI and DTI modalities and determine whether this network is disrupted for Veterans with mTBI. The candidate is a current VA postdoctoral fellow studying mTBI and neuroimaging research, has trained in the neuropsychological assessment of mTBI, has demonstrated a capacity to learn neuroimaging research methods across multiple imaging modalities and has collaborated with the proposed mentorship team on several prior grant applications and manuscripts related to neuroimaging and cognitive functions following TBI. Successful completion of this VA Career Development Award-2 with advance the candidate further toward a long-term research career goal of being an independent clinical researcher in the VA focusing on the integration of neuroimaging and neuropsychological assessment in the study of TBI. The CDA-2 will lead to independence not only through the experience of conducting the proposed research and training plan, but also by providing critical pilot data for a VA Merit Award. The specific immediate training objectives of this CDA-2 are to: (1) develop expertise in integrating neuroimaging modalities including fMRI and DTI, (2) develop expertise in the study of prospective memory, (3) achieve proficiency in advanced biostatistics and (4) continue my professional development aimed toward transitioning from a postdoctoral fellow into an independent VA clinical scientist. These goals will be achieved via collaboration with the identified mentorship team that will provide further specialized training in neuropsychological assessment, TBI research and neuroimaging techniques.

报告显示，在退伍军人中，轻度创伤性脑损伤（mTBI）的发病率很高

项目成果

The Effects of Nicotine and Cannabis Co-Use During Late Adolescence on White Matter Fiber Tract Microstructure.

青春期后期尼古丁和大麻共同使用对白质纤维束微观结构的影响。

• DOI: 10.15288/jsad.2022.83.287
• 发表时间: 2022
• 期刊: Journal of studies on alcohol and drugs
• 影响因子: 3.4
• 作者: Courtney,KellyE;Sorg,Scott;Baca,Rachel;Doran,Neal;Jacobson,Aaron;Liu,ThomasT;Jacobus,Joanna
• 通讯作者: Jacobus,Joanna

Elevated Intraindividual Variability in Executive Functions and Associations with White Matter Microstructure in Veterans with Mild Traumatic Brain Injury.

• DOI: 10.1017/s1355617720000879
• 发表时间: 2021-04
• 期刊: Journal of the International Neuropsychological Society : JINS
• 作者: Sorg SF;Merritt VC;Clark AL;Werhane ML;Holiday KA;Schiehser DM;Bondi M;Delano-Wood L
• 通讯作者: Delano-Wood L

Dissociation of BDNF Val66Met polymorphism on neurocognitive functioning in military veterans with and without a history of remote mild traumatic brain injury.

BDNF Val66Met 多态性的分离对有或没有远程轻度创伤性脑损伤史的退伍军人神经认知功能的影响。

• DOI: 10.1080/13854046.2020.1740324
• 发表时间: 2020
• 期刊: The Clinical neuropsychologist
• 作者: Merritt,VictoriaC;Clark,AlexandraL;Evangelista,NicoleD;Sorg,ScottF;Schiehser,DawnM;Delano-Wood,Lisa
• 通讯作者: Delano-Wood,Lisa

Severities in persistent mild traumatic brain injury related headache is associated with changes in supraspinal pain modulatory functions.

• DOI: 10.1177/17448069211037881
• 发表时间: 2021-01
• 期刊: Molecular pain
• 影响因子: 3.3
• 作者: Flowers M;Leung A;Schiehser DM;Metzger-Smith V;Delano-Wood L;Sorg S;Kunnel A;Wong A;Vaninetti M;Golshan S;Lee R
• 通讯作者: Lee R

Blast-Exposed Veterans With Mild Traumatic Brain Injury Show Greater Frontal Cortical Thinning and Poorer Executive Functioning.

• DOI: 10.3389/fneur.2018.00873
• 发表时间: 2018
• 期刊: Frontiers in neurology
• 影响因子: 3.4
• 作者: Clark AL;Merritt VC;Bigler ED;Bangen KJ;Werhane M;Sorg SF;Bondi MW;Schiehser DM;Delano-Wood L
• 通讯作者: Delano-Wood L