权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Thalamic Modulation of Auditory Cortical Processing via LP

通过 LP 进行听觉皮层处理的丘脑调节

基本信息

批准号：
10020782
负责人：
Li I Zhang
金额：
$ 55.4万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-08-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10020782
关键词：
Address Affect Anatomy Area Auditory Auditory area Axon Behavioral Brain Cell Nucleus Coupled Discrimination Frequencies Grant Homologous Gene Individual Investigation Knowledge Lateral posterior nucleus of thalamus Mediating Modality Mus Nature Neural Pathways Neurons Noise Pathway interactions Performance Pharmacology Play Preparation Presynaptic Terminals Primates Property Pulvinar structure Research Rodent Role Sensory Signal Transduction Slice Stratum Granulosum Synapses Testing Thalamic Nuclei Thalamic structure Viral Vision Visual Whole-Cell Recordings auditory discrimination auditory pathway auditory processing awake base cell type experimental study hippocampal pyramidal neuron in vivo individual response information processing inhibitory neuron insight multisensory neural circuit optogenetics receptive field response sensory cortex sensory processing disorder sound superior colliculus Corpora quadrigemina visual processing

项目摘要

Project Summary In this RO1 renewal application, we will explore functional roles of a higher-order thalamic nucleus, the lateral posterior nucleus (LP), in auditory cortical processing. LP is a rodent homologue of the pulvinar nucleus. While previous studies have been mostly focused on involvements of pulvinar in visual functions, there are salient connections between LP/pulvinar and auditory cortex, suggesting potential involvements of LP/pulvinar in auditory information processing as well. However, our knowledge on how LP influences auditory processing in the cortex is lacking. Recently in our preliminary experiments we observed that LP activity could suppress auditory responses in the primary auditory cortex (A1) of awake mice. This has prompted us to propose an extensive investigation into the functional contribution of LP to auditory cortical processing in A1. In Aim 1, we will perform in vivo recordings from individual neurons in supragranular and granular layers of A1 in awake mice and examined their auditory response properties before and after optogenetically inactivation and activation of LP. We will test the hypothesis that LP plays a role in enhancing auditory processing in A1 through a surround-suppression mechanism. In Aim 2, we will specifically manipulate the activity of the LP to A1 axon terminals either optogenetically or chemogenetically, and examine A1 neuron cell types that are innervated by the LP-A1 projection. We will test the hypothesis that the LP modulation of A1 responses is primarily mediated by the LP projection to layer 1 inhibitory neurons. In Aim 3, by manipulating activity of superior colliculus (SC), we will test the hypothesis that a SC-LP-A1 pathway mediates the bottom-up suppressive modulation of A1 responses. In addition, it can also mediate a cross- modality modulation of A1 responses by visual signals. Together, these experiments will enhance our understanding of functional roles of non-primary sensory thalamic nuclei in general.

项目总结