Cell-type basis for auditory processing in the inferior colliculus
下丘听觉处理的细胞类型基础
基本信息
- 批准号:10608768
- 负责人:
- 金额:$ 58.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-12-09 至 2027-11-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAnatomyAnimalsAuditoryAuditory PerceptionAuditory areaAuditory systemBehaviorBioinformaticsBrainBrain StemCatalogingCell NucleusCommunicationCoupledDevelopmentDorsalElectrophysiology (science)EndowmentExhibitsFeedbackGenesGenomicsHearingIceImpairmentInferior ColliculusLabelMediatingMethodsMolecularMusNeural PathwaysNeuronsNitric Oxide SynthaseNitric Oxide Synthase Type IOutputPatternPhysiologicalPopulationProceduresPropertyResearchRoleSliceSomatostatinSourceSpatial DistributionSpecific qualifier valueSynapsesTestingTransgenic OrganismsViralWhole-Cell RecordingsWorkauditory processingawakebasebiomarker identificationcandidate markercell typeexcitatory neuronhearing impairmentin vivoinhibitory neuroninsightmolecular markeroptogeneticsresponsescreeningsingle nucleus RNA-sequencingsoundtranscriptome sequencing
项目摘要
Project Summary
As a major hub of the central auditory system for hearing, the inferior colliculus (IC) receives both
bottom-up input from auditory brainstem nuclei, as well as feed-back input from the auditory cortex (AC).
IC contributes importantly to the processing of essential features of sounds for communication and
localization. Impaired IC processing has been associated with various hearing deficits. However,
despite extensive studies of central auditory processing in IC, our understanding of cell-type-specific
circuit mechanisms underlying the functional roles of the IC remains limited. In particular, how different
types of neurons in the three anatomical and functional subdivisions of IC, the central nucleus (ICc),
dorsal cortex (ICd), and external cortex (ICe), interact with each other and contribute differentially to the
auditory processing of IC remains largely unclear. Addressing this question requires identification of
molecular markers for cell types specifically located in each of the subdivisions. With 10X Genomics
single-nucleus RNA sequencing (snRNAseq), we made initial efforts in screening molecular markers
for different neuronal populations of IC. By identifying and verifying specific markers for IC subdivisions
and exploiting corresponding transgenic Cre mouse lines for the selected marker genes, we will then
characterize the anatomical connections and auditory response properties of the selected cell type and
its functional role in auditory processing functions. Our preliminary snRNAseq results suggest two
potential molecular markers specifically labeling subpopulations of excitatory neurons in the IC cortex.
Their verification will endow us with unique opportunities to investigate the specific and diverse
functional roles of ICd in auditory perception and behavior. Cutting-edge approaches in
electrophysiology, anatomy, and optogenetics coupled with intersectional or projection-based tagging
will be applied to address the differential functional contribution of diverse neuronal types in ICd as well
as the distinct underlying circuitry mechanisms.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Li I Zhang', 18)}}的其他基金
Synaptic circuitry mechanism for auditory cortical processing
听觉皮层处理的突触电路机制
- 批准号:
8862448 - 财政年份:2007
- 资助金额:
$ 58.86万 - 项目类别:
Thalamic Modulation of Auditory Cortical Processing via LP
通过 LP 进行听觉皮层处理的丘脑调节
- 批准号:
10466838 - 财政年份:2007
- 资助金额:
$ 58.86万 - 项目类别:
Synaptic circuitry mechanisms for auditory cortical processing
听觉皮层处理的突触电路机制
- 批准号:
8518287 - 财政年份:2007
- 资助金额:
$ 58.86万 - 项目类别:
Thalamic Modulation of Auditory Cortical Processing via LP
通过 LP 进行听觉皮层处理的丘脑调节
- 批准号:
9917600 - 财政年份:2007
- 资助金额:
$ 58.86万 - 项目类别:
Synaptic circuitry mechanism for auditory cortical processing
听觉皮层处理的突触电路机制
- 批准号:
8762331 - 财政年份:2007
- 资助金额:
$ 58.86万 - 项目类别:
Synaptic circuitry mechanisms for auditory cortical processing
听觉皮层处理的突触电路机制
- 批准号:
7660348 - 财政年份:2007
- 资助金额:
$ 58.86万 - 项目类别:
Synaptic circuitry mechanisms for auditory cortical processing
听觉皮层处理的突触电路机制
- 批准号:
8118959 - 财政年份:2007
- 资助金额:
$ 58.86万 - 项目类别:
Synaptic circuitry mechanisms for auditory cortical processing
听觉皮层处理的突触电路机制
- 批准号:
7455866 - 财政年份:2007
- 资助金额:
$ 58.86万 - 项目类别:
Thalamic Modulation of Auditory Cortical Processing via LP
通过 LP 进行听觉皮层处理的丘脑调节
- 批准号:
10238062 - 财政年份:2007
- 资助金额:
$ 58.86万 - 项目类别:
Thalamic Modulation of Auditory Cortical Processing via LP
通过 LP 进行听觉皮层处理的丘脑调节
- 批准号:
10020782 - 财政年份:2007
- 资助金额:
$ 58.86万 - 项目类别:
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