UNC-CH MOUSE BEHAVIOR RESEARCH

与北卡罗来纳大学教堂山分校的小鼠行为表型核心签订的小鼠行为研究合同为NIEHS的研究人员提供了设备齐全的小鼠行为测试设施，该设施提供了广泛的表型方案，用于表征新型转基因小鼠品系和人类疾病模型。NIEHS的研究人员能够在多个功能领域对他们的小鼠模型进行评估，包括运动和感觉能力、活动、类焦虑反应、社会互动、重复行为和认知。这些行为研究的结果为特定基因的功能、环境暴露的后果和其他影响行为的因素提供了新的信息。该合同每年为6-7个主要表型项目提供这些服务，这些项目由大约40只小鼠组成。小鼠行为表型核心负责人Sheryl Moy博士与个别调查人员密切合作，根据项目的具体细节设计行为测试组件，监督她的工作人员进行实验，然后在稿件准备方面提供统计分析和协助。

The Mouse Behavior Research Contract with the Mouse Behavioral Phenotyping Core at UNC Chapel Hill provides NIEHS investigators with access to a well-equipped mouse behavioral testing facility that offers broad phenotyping regimens for characterization of novel transgenic mouse lines and models of human disease. NIEHS investigators are able to have their mouse models evaluated across multiple functional domains, including motor and sensory ability, activity, anxiety-like responses, social interaction, repetitive behavior and cognition. The results from these behavioral studies provide new information on the function of specific genes, the consequences of environmental exposure and other factors influencing behavior. This contract provides these services for 6-7 major phenotyping projects, composed of approximately 40 mice, annually. Dr. Sheryl Moy, the head of the Mouse Behavioral Phenotyping Core, works closely with the individual investigators to design the behavioral testing battery based on the specific details of the project, oversees her staff to conduct the experiments and then provides statistical analysis and assistance in manuscript preparation.