The Integration of Trans-omics for Precision Medicine (TOPMED) and Other Heart, Lung, Blood and Sleep (HLBS) Data Sets with the Data Commons

NHLBI和执行者提出了这份目标和里程碑声明，以确定研究所合作的范围，以有效地为心、肺、血液和睡眠研究人员开发NHLBI数据阶段(存储、工具空间、访问和大数据赋权分析)，这些研究人员需要在大规模数据集上查找、访问、共享存储、交叉链接和计算。NHLBI数据阶段将是一个基于云的平台，提供工具、应用程序和工作流，以在安全的工作空间中实现这些功能。该资源将是一个组织合理的数字环境，集成在更广泛的NIH数据共享生态系统中(根据RM-17-026单独开发)，将加速高效的生物医学研究，并最大限度地提高社区参与度和生产率。最终，NHLBI数据阶段将推动发现，导致心、肺、血液和睡眠(HLBS)疾病的新诊断工具、治疗选择和预防策略。 在这种伙伴关系的整个生命周期中，NHLBI和执行者将根据工作的需要和进展协商里程碑、目标和交付内容。必要时，这些里程碑、目标和交付成果可以并行或相继出现。

The NHLBI and the Performer set forth this statement of objectives and milestones to define the scope of a partnership for the Institute to effectively develop an NHLBI Data STAGE (Storage, Toolspace, Access and analytics for biG data empowerment) for heart, lung, blood, and sleep research investigators who need to find, access, share store, cross-link, and compute on large scale data sets. The NHLBI Data STAGE will be a cloud-based platform that provides tools, applications, and workflows to enable these capabilities in secure workspaces. The resource will be a rationally organized digital environment, integrated within the broader NIH Data Commons ecosystem (being separately developed under RM-17-026), that will accelerate efficient biomedical research and maximize community engagement and productivity. Ultimately, the NHLBI Data STAGE will drive discovery leading to novel diagnostic tools, therapeutic options, and prevention strategies for heart, lung, blood, and sleep (HLBS) disorders. Throughout the life-cycle of this partnership, the NHLBI and the Performer will negotiate milestones, objectives, and deliverables based on the needs and progress of the effort. These milestones, objectives and deliverables may occur in parallel or sequentially as necessary.