The Integration of Trans-omics for Precision Medicine (TOPMED) and Other Heart, Lung, Blood and Sleep (HLBS) Data Sets with the Data Commons

NHLBI和执行者提出了这一目标和里程碑声明，以确定研究所合作的范围，以便有效地为心脏、肺、血液和睡眠研究人员开发NHLBI数据阶段（大数据授权的存储、工具空间、访问和分析），这些研究人员需要查找、访问、共享、存储、交叉链接和计算大规模数据集。NHLBI Data STAGE将是一个基于云的平台，提供工具、应用程序和工作流，以在安全的工作空间中实现这些功能。该资源将是一个合理组织的数字环境，集成在更广泛的NIH数据共享生态系统中（在RM-17-026下单独开发），这将加速有效的生物医学研究，并最大限度地提高社区参与和生产力。最终，NHLBI数据阶段将推动发现导致心脏、肺、血液和睡眠（HLBS）疾病的新型诊断工具、治疗方案和预防策略。

The NHLBI and the Performer set forth this statement of objectives and milestones to define the scope of a partnership for the Institute to effectively develop an NHLBI Data STAGE (Storage, Toolspace, Access and analytics for biG data empowerment) for heart, lung, blood, and sleep research investigators who need to find, access, share store, cross-link, and compute on large scale data sets. The NHLBI Data STAGE will be a cloud-based platform that provides tools, applications, and workflows to enable these capabilities in secure workspaces. The resource will be a rationally organized digital environment, integrated within the broader NIH Data Commons ecosystem (being separately developed under RM-17-026), that will accelerate efficient biomedical research and maximize community engagement and productivity. Ultimately, the NHLBI Data STAGE will drive discovery leading to novel diagnostic tools, therapeutic options, and prevention strategies for heart, lung, blood, and sleep (HLBS) disorders. Throughout the life-cycle of this partnership, the NHLBI and the Performer will negotiate milestones, objectives, and deliverables based on the needs and progress of the effort. These milestones, objectives and deliverables may occur in parallel or sequentially as necessary.