The Integration of Trans-omics for Precision Medicine (TOPMED) and Other Heart, Lung, Blood and Sleep (HLBS) Data Sets with the Data Commons

精准医学跨组学 (TOPMED) 和其他心、肺、血液和睡眠 (HLBS) 数据集与数据共享的集成

• 批准号: 10267910
• 负责人: Paul Avillach
• 金额: $ 200万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2022-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10267910
• 关键词: Big Data Methods; Biomedical Research; Blood; Communities; Data; Data Commons; Data Set; Ecosystem; Environment; Heart; Heart Diseases; Hematological Disease; Institutes; Life Cycle Stages; Lung; Lung diseases; Mediation; National Heart, Lung, and Blood Institute; Prevention strategy; Productivity; Research; Research Personnel; Resources; Secure; Sleep; Sleep Disorders; Therapeutic; Trans-Omics for Precision Medicine; United States National Institutes of Health; base; cloud based; crosslink; digital; empowerment; large scale data; novel diagnostics; tool

The NHLBI and the Performer set forth this statement of objectives and milestones to define the scope of a partnership for the Institute to effectively develop an NHLBI Data STAGE (Storage, Toolspace, Access and analytics for biG data empowerment) for heart, lung, blood, and sleep research investigators who need to find, access, share store, cross-link, and compute on large scale data sets. The NHLBI Data STAGE will be a cloud-based platform that provides tools, applications, and workflows to enable these capabilities in secure workspaces. The resource will be a rationally organized digital environment, integrated within the broader NIH Data Commons ecosystem (being separately developed under RM-17-026), that will accelerate efficient biomedical research and maximize community engagement and productivity. Ultimately, the NHLBI Data STAGE will drive discovery leading to novel diagnostic tools, therapeutic options, and prevention strategies for heart, lung, blood, and sleep (HLBS) disorders. Throughout the life-cycle of this partnership, the NHLBI and the Performer will negotiate milestones, objectives, and deliverables based on the needs and progress of the effort. These milestones, objectives and deliverables may occur in parallel or sequentially as necessary.

NHLBI和执行者提出了这一目标和里程碑声明，以定义研究所的合作伙伴关系范围，从而有效地为需要查找、访问、共享存储、交叉链接和计算大规模数据集的心脏、肺、血液和睡眠研究人员开发NHLBI数据阶段（存储、工具空间、访问和分析，以实现大数据授权）。 NHLBI Data STAGE将是一个基于云的平台，提供工具、应用程序和工作流程，以在安全的网络环境中实现这些功能。 该资源将是一个合理组织的数字环境，集成在更广泛的NIH数据共享生态系统（根据RM-17-026单独开发）中，这将加速有效的生物医学研究，并最大限度地提高社区参与度和生产力。 最终，NHLBI数据阶段将推动发现新的诊断工具，治疗方案和心脏，肺，血液和睡眠（HLBS）疾病的预防策略。 在此合作关系的整个生命周期内，NHLBI和执行者将根据工作的需求和进度协商里程碑、目标和可交付成果。 这些里程碑、目标和可交付成果可以根据需要并行或顺序发生。