Development of small molecule modulators of WDR5/MLL1 protein-protein binding (Chemical Biology Consortium/NCI Experimental Therapeutics Collaboration)

在此期间，项目团队通过对十几种类似物进行细胞热移分析（CETSA）数据，并开发了一个强大的CETSA分析算法来帮助数据解释，为更大规模的WDR5合作提供了支持。

During this period, the project team has supported the larger WDR5 collaboration by conducting cellular thermal shift assay (CETSA) data for dozen of analogs, and developed a robust CETSA analysis algorithm to aid with data interpretation. As a center, the NCGC has fostered and maintained over 130 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to dozens of high-throughput screens and a number of medicinal chemistry campaigns to further improve on screening hits, providing our collaborators and the general research community with publications and a variety of promising small molecule probes and leads. In addition, the NCGC has worked to advance a number of informatic initiatives to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.