Achieving Direct Functional Imaging of Brain Electrophysiology: Nanofabricated Cell-sized Electronic Sensors for Magnetic Resonance Imaging
实现脑电生理学的直接功能成像:用于磁共振成像的纳米制造细胞大小的电子传感器
基本信息
- 批准号:10001896
- 负责人:
- 金额:$ 227.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAwardBlood flowBrainBrain DiseasesBrain imagingBrain regionCell SizeCognitionCommunicationDetectionDevelopmentDevicesElectrodesElectromagneticsElectrophysiology (science)EngineeringEpilepsyEventFunctional ImagingFunctional Magnetic Resonance ImagingFunctional disorderGoalsHumanImageImplantIn SituMagnetic Resonance ImagingMeasuresMethodsMicroelectrodesMonitorNeuronsNoiseOpticsPatientsPhysiologyPrincipal InvestigatorQuadriplegiaQuality of lifeResolutionRodentSignal TransductionTechnologyTissuesValidationWireless Technologybrain volumeimaging probeimprovedinnovationmagnetic fieldminimally invasivenanofabricationnanoscaleneurophysiologyneurotransmissionnovelrelating to nervous systemresponsesensortechnology validation
项目摘要
Project Summary
There is currently a surging effort to develop the necessary technologies for recording neural activity
from the entire volume of the brain in parallel. A whole-brain direct readout of neural signals will be critical to
understanding the elusive cross-regional communication grid underlying brain function and dysfunction. The
overall goal of this new innovator award is the development and application of a new form of brain imaging us-
ing electromagnetic circuits that can be deployed throughout the brain and provide parallel volumetric electro-
physiological readouts of neural activity. The project relies on recent advances made by the principal investiga-
tor, demonstrating the use of tetherless microelectronic neural interfaces that transduce neurophysiological
events wirelessly to detectable magnetic field perturbations, and are monitored by functional magnetic reson-
ance imaging (fMRI). By combining the unique three-dimensional capabilities of fMRI to obtain functional rea-
douts from the entire volume of the brain, with electromagnetic probes—that are able to directly record electro-
physiological neural activity in-situ and transmit its response to the MRI hardware—this project is aiming to
transform the way we acquire brain signals. We will use novel nanofabrication methods to pioneer cell-sized
wireless probes, while employing existing state-of-the-art MRI-compatible microelectrode arrays in rodents for
rigorous validation of the technology and to decouple the electrophysiogical readouts from intrinsic fMRI blood
flow signals. The engineering advances that occurred in recent years have propelled the capabilities of both
electrical and optical implantable probes for brain recording, achieving nanometer scale spatial resolution, high
signal-to-noise ratio and temporal response, and increasingly favorable tissue-device interactions. Implantable
electrode array devices provide us with multiplexed recordings of electrical signals from tens or hundreds of
neurons with high spatial precision at the cellular level. These devices have been successfully implanted in
human patients for the treatment and monitoring of epilepsy and to improve quality of life for tetraplegic pa-
tients. The neuroelectronic fMRI probes that will be developed under the umbrella of this award will greatly
augment these capabilities. Firstly, by presenting a different approach whereby minimally invasive devices are
powered by the MRI scanner itself and do not require bulky on-board power, and secondly, by interacting with
the imaging scanner to transmit electrical neural activity to the detection hardware outside of the brain with no
requirement for a tethered connection. The sensors will be used to directly detect electrical neural activity in
three dimensions, and will help pave the way towards tracing the cross-regional origins of both normal and ab-
normal brain physiology.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Aviad Hai其他文献
Aviad Hai的其他文献
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{{ truncateString('Aviad Hai', 18)}}的其他基金
Wireless Sensors for Functional MRI of Brain Seizures
用于大脑癫痫发作功能 MRI 的无线传感器
- 批准号:
10002216 - 财政年份:2019
- 资助金额:
$ 227.85万 - 项目类别:
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