Wireless Sensors for Functional MRI of Brain Seizures

项目摘要 NIH K01指导性研究项目的中心目标是开发一种新型无线 用于脑部癫痫的直接功能磁共振成像(FMRI)的微电子传感器。功能磁共振成像有 在过去的二十年里，作为一种重要的非侵入性诊断和监测工具出现了 神经病理障碍和脑损伤。然而，它依赖于血氧水平依赖(BOLD) 信号，主要来源于神经血管，是神经活动的基本间接表现。 这排除了抑制性神经活动和兴奋性神经活动之间的区别，从而有可能出现假阳性和假 脑部癫痫的诊断和监测中的阴性。在这个项目中，接受指导的调查员将 结合他在记录神经活动的微电子探测器方面的专业知识，并将它们与 主办机构的神经成像能力，开发无线核磁共振传感器，以独特和特定的 探讨啮齿类动物病理性脑模式的时间和跨区域表现问题 癫痫模型。这种新形式的大脑成像将允许获取癫痫发作的直接读数 使用MRI，利用其三维编码能力来研究异常放电模式和神经 整个大脑的功能障碍。这里提出的研究代表着一个新的和创新的 治疗脑部疾病的神经科学和神经学研究领域。新方法 由被指导的科学家在这里提出的将广泛适用于神经生物学中的问题，并将 改变神经学家研究大脑在神经病理障碍中的综合功能的能力。 该方法还将有助于在诊断医学中建立一条新的途径，从而使响应性微制造 有源设备推动MRI对比度的变化，类似于传统的化学造影剂，并且可以 功能磁共振成像的细胞生理学方面的报告。Aviad Hai博士将担任首席研究员 为了这个项目。海博士是一位神经生物学工程师，专注于新奇生物的开发和应用 用于神经成像和脑记录的传感器。海博士在这项研究中做出了几项重要贡献 利用核磁共振研究啮齿动物大脑生理过程的新诊断显像剂，AS 以及用于记录和刺激大脑活动的纳米工程探测器的开发。他的广博 在微电子工程和成像部分的专业知识和发表的贡献 该项目使他处于领导这个高度多学科指导的项目的天然位置。海博士将执导 微电子制造、体外和体内动物验证的努力，所有这些都在HIS 专业知识。

Project Summary The central aim of this NIH K01 mentored research project is the development of a new type of wireless microelectronic sensors for direct functional magnetic resonance imaging (fMRI) of brain seizures. fMRI has emerged in the past two decades as a prominent tool for noninvasive diagnosis and monitoring of neuropathological disorders and brain injury. However, it relies on blood oxygen level-dependent (BOLD) signal, which is mainly of neurovascular origin and is a fundamentally indirect manifestation of neural activity. This precludes the distinction between inhibitory and excitatory neural activity, risking false positives and false negatives in the diagnosis and monitoring of brain seizures. In this project, the mentored investigator will combine his expertise in microelectronic probes for the recording of neural activity, and combine them with neuroimaging capabilities of the host institution, to develop wireless MRI sensors to uniquely and specifically address questions of temporal and cross-regional manifestations of pathological brain patterns in rodent models of epilepsy. This new form of brain imaging will allow for the acquisition of direct readouts of seizures using MRI, employing its three-dimensional encoding capabilities to study abnormal firing patterns and neural dysfunction across the brain. The research proposed here represents an initial step in a new and innovative field for neuroscience and neurological research for the treatment of brain diseases. The novel methods propose here by the mentored scientist will be broadly applicable to problems in neurobiology, and will transform the ability of neuroscientists to study integrative functions of the brain in neuropathological disorders. The approach will also help to establish a new path in diagnostic medicine whereby responsive microfabricated active devices drive the change in MRI contrast similarly to conventional chemical contrast agents, and can report on aspects of cellular physiology for functional MRI. Aviad Hai, PhD, will serve as principal investigator for this project. Dr. Hai is a neurobiological engineer that focuses on the development and application of novel sensors for neuroimaging and brain recording.. Dr. Hai has made several key contributions in the development of new diagnostic imaging agents for studying physiological processes in the brain using MRI in rodents, as well as the development nano-engineered probes for recording and stimulation of brain activity. His extensive expertise and published contributions in both the microelectronic engineering and imaging portions of the project put him at a natural position of leading this highly multidisciplinary mentored project. Dr. Hai will direct efforts of microelectronic fabrication, in-vitro and in-vivo validation in animals, all of which are within his expertise.