Implantable Nanophotonic Sensors for in Vivo Immunoresponse

用于体内免疫反应的植入式纳米光子传感器

• 批准号: 10002722
• 负责人: Mekhail Anwar
• 金额: $ 242.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10002722
• 关键词: Biological; Biological Markers; Biopsy; Cancer Biology; Complex; Custom; Disease; Environment; Goals; Immune response; Immunotherapy; In Situ; Microscopy; Molecular; Molecular Target; Monitor; Patients; Physiological; Radiation; Reaction Time; Role; Site; Speed; Time; Tumor Biology; Wireless Technology; cancer therapy; data exchange; fluorescence imaging; fluorescence microscope; imaging platform; immune checkpoint; implanted sensor; in vivo; innovation; millimeter; nanophotonic; novel therapeutics; personalized care; personalized medicine; photonics; response; sensor; tumor; tumor microenvironment

PROJECT SUMMARY Visualizing real-time physiologic and molecular tumor response to targeted molecular agents and radiation, within the complex in situ host environment - in effect a wireless biopsy - provides a heretofore unseen window into cancer biology, guiding optimal, personalized patient care. We aim to develop a versatile platform imaging the dynamic immune response within the patient’s tumor microenvironment. Here we introduce a first-in-class, fully implantable, wireless, microfabricated electronic-photonic platform for real-time in vivo tumor monitoring. This platform can be utilized with any tumor type as well as non-oncologic applications where biomarkers are essential. The platform will provide the full functionality of a fluorescence microscope, in a millimeter-scale implantable sensor. in vivo microscopy enables intratumoral fluorescent imaging, leveraging an armamentarium of existing targeted biologics unveiling both tumor biology within the complex host environment and early indicators of tumor response. We will detect and explore the role of the immune response at the site of disease dramatically increasing sensitivity while providing spatial localization - key to unlocking a systemic effect. Made possible by recent innovations in wireless power and data transfer, and unprecedented integration of high-speed circuits with photonics, these advances will unlock an entirely new paradigm of real- time response assessment enabling effective application of novel therapeutics and immunotherapy, customized to patient’s tumor biology.

项目总结