Implantable Nanophotonic Sensors for in Vivo Immunoresponse

用于体内免疫反应的植入式纳米光子传感器

基本信息

批准号：
10002722
负责人：
Mekhail Anwar
金额：
$ 242.25万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-10 至 2025-06-30
项目状态：
未结题

项目摘要

PROJECT SUMMARY Visualizing real-time physiologic and molecular tumor response to targeted molecular agents and radiation, within the complex in situ host environment - in effect a wireless biopsy - provides a heretofore unseen window into cancer biology, guiding optimal, personalized patient care. We aim to develop a versatile platform imaging the dynamic immune response within the patient’s tumor microenvironment. Here we introduce a first-in-class, fully implantable, wireless, microfabricated electronic-photonic platform for real-time in vivo tumor monitoring. This platform can be utilized with any tumor type as well as non-oncologic applications where biomarkers are essential. The platform will provide the full functionality of a fluorescence microscope, in a millimeter-scale implantable sensor. in vivo microscopy enables intratumoral fluorescent imaging, leveraging an armamentarium of existing targeted biologics unveiling both tumor biology within the complex host environment and early indicators of tumor response. We will detect and explore the role of the immune response at the site of disease dramatically increasing sensitivity while providing spatial localization - key to unlocking a systemic effect. Made possible by recent innovations in wireless power and data transfer, and unprecedented integration of high-speed circuits with photonics, these advances will unlock an entirely new paradigm of real- time response assessment enabling effective application of novel therapeutics and immunotherapy, customized to patient’s tumor biology.

项目摘要可视化实时生理和分子肿瘤对靶向分子剂和辐射的反应，在复杂的原位主机环境中 - 实际上是无线活检 - 迄今为止提供了一个看不见的窗口进入癌症生物学，指导最佳的个性化患者护理。我们旨在开发多功能平台成像患者肿瘤微环境中的动态免疫反应。在这里，我们介绍了一流的完全植入的，无线，微制作的电子光子平台，用于实时体内肿瘤监测。该平台可以使用任何肿瘤类型以及生物标记物的非综合应用基本的。该平台将在毫米级以荧光显微镜的全部功能植入传感器。体内显微镜可以实现肿瘤内荧光成像，利用现有靶向生物制剂的Armamentarium在复杂宿主环境中揭示了两种肿瘤生物学和肿瘤反应的早期指标。我们将检测并探索免疫反应在现场的作用疾病在提供空间定位的同时显着提高敏感性 - 解锁系统性的关键影响。通过无线功率和数据传输的最新创新和前所未有的创新将高速电路与光子学的整合，这些进步将解锁全新的实地范式时间反应评估可以有效应用新型治疗和免疫疗法，根据患者的肿瘤生物学定制。