Implantable Nanophotonic Sensors for in Vivo Immunoresponse

项目总结 可视化实时生理和分子肿瘤对靶向分子制剂和辐射的反应， 在复杂的原位宿主环境中--实际上是无线活组织检查--提供了一个迄今看不见的窗口 进入癌症生物学，指导最佳的、个性化的患者护理。我们的目标是开发一个多功能的成像平台 患者肿瘤微环境内的动态免疫反应。在这里我们介绍一位一流的， 完全可植入、无线、微型制造的电子-光子平台，用于实时体内肿瘤监测。 该平台可用于任何肿瘤类型以及生物标记物 必不可少的。该平台将提供毫米级荧光显微镜的全部功能 植入式传感器。活体显微镜使肿瘤内荧光成像成为可能，利用 现有靶向生物制剂展示复杂宿主环境中的肿瘤生物学 以及肿瘤反应的早期指标。我们将在现场检测和探索免疫反应的作用 疾病的敏感性显著增加，同时提供空间定位-解锁系统性疾病的关键 效果。无线电源和数据传输的最新创新使之成为可能，而且史无前例 将高速电路与光子学相结合，这些进步将开启一种全新的真实- 能够有效应用新疗法和免疫疗法的时间反应评估， 根据患者的肿瘤生物学进行定制。

PROJECT SUMMARY Visualizing real-time physiologic and molecular tumor response to targeted molecular agents and radiation, within the complex in situ host environment - in effect a wireless biopsy - provides a heretofore unseen window into cancer biology, guiding optimal, personalized patient care. We aim to develop a versatile platform imaging the dynamic immune response within the patient’s tumor microenvironment. Here we introduce a first-in-class, fully implantable, wireless, microfabricated electronic-photonic platform for real-time in vivo tumor monitoring. This platform can be utilized with any tumor type as well as non-oncologic applications where biomarkers are essential. The platform will provide the full functionality of a fluorescence microscope, in a millimeter-scale implantable sensor. in vivo microscopy enables intratumoral fluorescent imaging, leveraging an armamentarium of existing targeted biologics unveiling both tumor biology within the complex host environment and early indicators of tumor response. We will detect and explore the role of the immune response at the site of disease dramatically increasing sensitivity while providing spatial localization - key to unlocking a systemic effect. Made possible by recent innovations in wireless power and data transfer, and unprecedented integration of high-speed circuits with photonics, these advances will unlock an entirely new paradigm of real- time response assessment enabling effective application of novel therapeutics and immunotherapy, customized to patient’s tumor biology.