Implantable Nanophotonic Sensors for in Vivo Immunoresponse

项目摘要 可视化实时生理和分子肿瘤对靶向分子试剂和辐射的反应， 在复杂的原位宿主环境中-实际上是无线活检-提供了一个迄今为止看不见的窗口 进入癌症生物学，指导最佳的，个性化的病人护理。我们的目标是开发一个多功能的平台成像 患者肿瘤微环境中的动态免疫反应。在这里，我们介绍一个一流的， 用于实时体内肿瘤监测的完全可植入、无线、微制造电子-光子平台。 该平台可用于任何肿瘤类型以及非肿瘤应用，其中生物标志物是 具有本质意义该平台将提供毫米级荧光显微镜的全部功能 植入式传感器体内显微镜能够进行肿瘤内荧光成像， 现有靶向生物制剂的医疗设备揭示了复杂宿主环境中的肿瘤生物学 和肿瘤反应的早期指标。我们将检测和探索免疫反应在该部位的作用 在提供空间定位的同时显著提高了灵敏度--这是解锁系统性 效果无线供电和数据传输方面的最新创新使之成为可能， 高速电路与光子学的集成，这些进步将开启一个全新的真实的范例， 时间响应评估使得能够有效应用新的治疗剂和免疫治疗， 根据患者的肿瘤生物学进行定制。

PROJECT SUMMARY Visualizing real-time physiologic and molecular tumor response to targeted molecular agents and radiation, within the complex in situ host environment - in effect a wireless biopsy - provides a heretofore unseen window into cancer biology, guiding optimal, personalized patient care. We aim to develop a versatile platform imaging the dynamic immune response within the patient’s tumor microenvironment. Here we introduce a first-in-class, fully implantable, wireless, microfabricated electronic-photonic platform for real-time in vivo tumor monitoring. This platform can be utilized with any tumor type as well as non-oncologic applications where biomarkers are essential. The platform will provide the full functionality of a fluorescence microscope, in a millimeter-scale implantable sensor. in vivo microscopy enables intratumoral fluorescent imaging, leveraging an armamentarium of existing targeted biologics unveiling both tumor biology within the complex host environment and early indicators of tumor response. We will detect and explore the role of the immune response at the site of disease dramatically increasing sensitivity while providing spatial localization - key to unlocking a systemic effect. Made possible by recent innovations in wireless power and data transfer, and unprecedented integration of high-speed circuits with photonics, these advances will unlock an entirely new paradigm of real- time response assessment enabling effective application of novel therapeutics and immunotherapy, customized to patient’s tumor biology.