Chip-Scale Intraoperative Optical Navigation with Immunotargeted Upconverting Nanoparticles
使用免疫靶向上转换纳米颗粒的芯片级术中光学导航
基本信息
- 批准号:10743477
- 负责人:
- 金额:$ 65.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-15 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffinityAlloysAnimal ModelAntibodiesAntibody SpecificityBindingBiological AssayBreast Cancer ModelCancer DetectionCell Culture TechniquesClinicalCoupledDepositionDetectionDevelopmentDiffuseDiseaseEngineeringExcisionG-substrateGoalsImageImage-Guided SurgeryImaging technologyImmunoglobulin GIndividualLabelLanthanoid Series ElementsLasersLeftLymph Node InvolvementMalignant NeoplasmsMalignant neoplasm of prostateMicroscopeMicroscopicModelingModernizationMusNanotechnologyNatureOperative Surgical ProceduresOpticsOutcomePatientsPhotonsProtein EngineeringProteinsRecombinantsResectableResidual CancersResidual NeoplasmSensitivity and SpecificitySiliconSpeedSurfaceSurgical InstrumentsSurgical ModelsSurgical marginsTechnologyTestingThinnessTimeTissue SampleTissue StainsTissue imagingTissuesToxic effectVisible RadiationVisualizationXenograft Modelabsorptionantibody engineeringbiomaterial compatibilitycancer carecancer cellcancer imagingcancer riskcancer subtypescancer surgerycrosslinkdesigndetectordiagnostic platformfluorophoreimagerimaging modalityimprovedimproved outcomeinstrumentinstrumentationintegrated circuitlight emissionlymph nodesmalignant breast neoplasmmetermicroscopic imagingmolecular imagingnanonanocrystalnanoparticlenanoshellneoplastic cellnew technologynoveloptical imagingpre-clinicalsensortheranosticstooltumortwo-photon
项目摘要
Project Summary/Abstract
Residual cancer cells left behind following surgery increase the chance of cancer returning
in almost every cancer subtype. The current inability to identify these tumor cells during surgery
hinders cancer care across the spectrum, including breast and prostate cancers, as 20-40% of
these patients suffer from positive margins, which doubles the risk of cancer returning.
This proposal solves this problem through an original approach for ultrasensitive optical
imaging of cancer cells in live tissue and during surgery. Current intraoperative imaging methods
are unable to achieve high sensitivity both on the tissue surface and at depth due to inherent
physical limits of both current optical probes and their requisite imagers. They are also too bulky
to be integrated onto modern surgical tools, which could guide precision surgery with far greater
accuracy than achievable today. Here, we address these dual challenges by introducing a wholly
new imaging strategy integrating nanotechnology, protein engineering, and advanced imager
design with the goal of real-time highly sensitive intraoperative imaging of cancer cells, both on
the surface and at depth. We propose major advances in nanotechnology to redesign
upconverting nanoparticles as optical probes that can be safely imaged in tissue, protein
engineering to produce antibodies that selectively target the probes to tumor, and detector
engineering to build an ultrathin imaging chip, directly integrated into surgical instrumentation.
The combination of these novel technologies transforms instruments themselves into imagers to
dramatically increase the sensitivity in identifying cancer cells, with the ultimate goal of being able
to identify, in real time, all residual disease.
项目总结/文摘
项目成果
期刊论文数量(0)
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Mekhail Anwar其他文献
Mekhail Anwar的其他文献
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{{ truncateString('Mekhail Anwar', 18)}}的其他基金
Implantable Nanophotonic Sensors for in Vivo Immunoresponse
用于体内免疫反应的植入式纳米光子传感器
- 批准号:
10002722 - 财政年份:2020
- 资助金额:
$ 65.53万 - 项目类别:
An Ultra-Thin Molecular Imaging Skin for Intraoperative Imaging of Microscopic Residual Disease in Cancer
超薄分子成像皮肤,用于癌症微小残留病灶的术中成像
- 批准号:
9883791 - 财政年份:2019
- 资助金额:
$ 65.53万 - 项目类别:
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