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Vascular Signaling Plasticity - Novel Concepts and Tools for Studying Neurovascular Interactions in Health and Disease

血管信号可塑性 - 研究健康和疾病中神经血管相互作用的新概念和工具

基本信息

批准号：
10002378
负责人：
Thomas A Longden
金额：
$ 231.75万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2025-03-31
项目状态：
未结题

项目摘要

SUMMARY The brain requires a vast amount of energy (around 20% of the total generated in the body) to function normally. Despite this, the brain lacks energy stores and instead uses a ‘just-in-time’ energy delivery system known as ‘functional hyperemia’, in which local blood flow increases in response to spikes in neuronal activity. This process is underlain by a range of redundant ‘neurovascular coupling’ mechanisms that collectively ensure the fidelity of the blood flow response to feed activity. We have discovered that these mechanisms display a striking form of plasticity, in which chronic changes in neuronal energy requirements lead to reprogramming of these vascular signaling mechanisms to augment or dampen the local delivery of blood. We term this phenomenon vascular signaling plasticity (VSP). Importantly, VSP is disrupted in a mouse model of Alzheimer’s disease, implying that loss of this process may lead to a mismatch between energy supply and demand and impair neuronal function. Here, we propose a program of research in which we develop novel workflows for chronic imaging of VSP in awake behaving animals, followed by detailed molecular analyses of the mechanisms that underlie VSP in the same cells that we image. This work will reveal a previously unknown and unsuspected mechanism for blood flow control in the brain that is critical for neuronal health, opening a new field of research into the phenomenon of VSP. Completion of this project will deliver a range of imaging tools to enable us to image blood flow and aspects of VSP non-invasively over long periods in vivo, and our work will culminate in the development of a novel brain endothelium-specific gene therapy aimed at protecting or restoring VSP in dementia, thereby safeguarding neuronal metabolism and function.

总结