Nanomagnetic isolation and sensing for mobile HIV-1 self-testing

用于移动 HIV-1 自检的纳米磁隔离和传感

基本信息

  • 批准号:
    10002182
  • 负责人:
  • 金额:
    $ 46.27万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-08-26 至 2022-07-31
  • 项目状态:
    已结题

项目摘要

Project Summary Antiretroviral treatment (ART) requires close monitoring of HIV-1 plasma viremia to confirm viral suppression, and to identify viral rebound due to nonadherence or drug resistance to initiate timely treatment modification. Thus, frequent efficient monitoring for HIV in blood via methods that are accessible for home self-testing is a critical need. Current self-detection strategies only detect antibody, and existing virus detection methods require extensive equipment and expertise (RNA) and/or have limited sensitivity (antigen). We aim to fill this gap with the development of an inexpensive, automated, portable system that will detect new or recurrent plasma viremia with high specificity and sufficient sensitivity for self-monitoring in these contexts. The ultimate goal of this project is to develop a platform technology for low-cost (< $2/test) point-of-care nucleic acid diagnostics for use on crude human samples (plasma) to quantitate viral RNA with a detection limit < 10 virus / sample (equivalent to a clinically-relevant threshold of 1000 copy/ml on 10 ul finger prick blood). The method will be simple to perform and will not require complex amplification procedures such as PCR. The novelty of our approach is to combine two innovative technologies invented by our team - one for target separation and concentration suitable for any starting blood volume, and one for label-free nucleic acid detection without amplification – into an integrated device. The goal of our R66 is to design a laboratory-based integrated system to demonstrate quantitation of HIV viral load on tissue culture derived virus spiked into healthy plasma. The goals of our R33 are advanced development of our technology into a fully-automated handheld mobile-phone based device to be used by non-microfluidic experts, and evaluation using banked clinical samples through partnership with Penn's Center for AIDS Research.
项目总结

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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David Aaron Issadore其他文献

David Aaron Issadore的其他文献

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{{ truncateString('David Aaron Issadore', 18)}}的其他基金

High Throughput Digital Droplet ELISA for Ultrasensitive Multiplexed Diagnostics
用于超灵敏多重诊断的高通量数字液滴 ELISA
  • 批准号:
    9889673
  • 财政年份:
    2020
  • 资助金额:
    $ 46.27万
  • 项目类别:
High Throughput Digital Droplet ELISA for Ultrasensitive Multiplexed Diagnostics
用于超灵敏多重诊断的高通量数字液滴 ELISA
  • 批准号:
    10359798
  • 财政年份:
    2020
  • 资助金额:
    $ 46.27万
  • 项目类别:
Nanomagnetic isolation and sensing for mobile HIV-1 self-testing
用于移动 HIV-1 自检的纳米磁隔离和传感
  • 批准号:
    10663625
  • 财政年份:
    2019
  • 资助金额:
    $ 46.27万
  • 项目类别:
Nanomagnetic isolation and sensing for mobile HIV-1 self-testing
用于移动 HIV-1 自检的纳米磁隔离和传感
  • 批准号:
    10224709
  • 财政年份:
    2019
  • 资助金额:
    $ 46.27万
  • 项目类别:
A nanomagnetic platform technology to characterize traumatic brain injury using brain derived extracellular vesicles
使用脑源性细胞外囊泡表征创伤性脑损伤的纳米磁性平台技术
  • 批准号:
    9788528
  • 财政年份:
    2018
  • 资助金额:
    $ 46.27万
  • 项目类别:
A nanomagnetic platform technology to characterize traumatic brain injury using brain derived extracellular vesicles
使用脑源性细胞外囊泡表征创伤性脑损伤的纳米磁性平台技术
  • 批准号:
    10261451
  • 财政年份:
    2018
  • 资助金额:
    $ 46.27万
  • 项目类别:
A nanomagnetic platform technology to characterize traumatic brain injury using brain derived extracellular vesicles
使用脑源性细胞外囊泡表征创伤性脑损伤的纳米磁性平台技术
  • 批准号:
    10019696
  • 财政年份:
    2018
  • 资助金额:
    $ 46.27万
  • 项目类别:
Rapid unbiased isolation and in situ RNA analysis of circulating tumor cells using a magnetic micropore-based diagnostic chip
使用基于磁性微孔的诊断芯片对循环肿瘤细胞进行快速无偏分离和原位 RNA 分析
  • 批准号:
    9277638
  • 财政年份:
    2017
  • 资助金额:
    $ 46.27万
  • 项目类别:
Rapid unbiased isolation and in situ RNA analysis of circulating tumor cells using a magnetic micropore-based diagnostic chip
使用基于磁性微孔的诊断芯片对循环肿瘤细胞进行快速无偏分离和原位 RNA 分析
  • 批准号:
    9752954
  • 财政年份:
    2017
  • 资助金额:
    $ 46.27万
  • 项目类别:
A micro Hall chip for circulating microvesicle based cancer monitoring
用于基于循环微泡的癌症监测的微型霍尔芯片
  • 批准号:
    8733954
  • 财政年份:
    2014
  • 资助金额:
    $ 46.27万
  • 项目类别:

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