Antimicrobial dermal matrices to promote infection free wound closure in cutaneous wounds

抗菌真皮基质促进皮肤伤口无感染伤口闭合

• 批准号: 10001816
• 负责人: Manav Mehta
• 金额: $ 169.99万
• 依托单位: GEL4MED, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10001816
• 关键词: American; Amputation; Anti-Bacterial Agents; Antibiotic Resistance; Antibiotics; Area; Bacteria; Bacterial Antibiotic Resistance; Biocompatible Materials; Biological; Biomedical Technology; Biophysics; Caring; Cell-Matrix Junction; Cells; Cellular Infiltration; Centers for Disease Control and Prevention (U.S.); Cessation of life; Charge; Clinic; Clinical; Data; Dermal; Development; Drug resistance; Effectiveness; Environment; Exhibits; Family suidae; Formulation; Gel; Goals; Gram-Negative Bacteria; Guidelines; Health; Hospitals; Hydrogels; In Vitro; Infection; Infection prevention; Inpatients; Local Anti-Infective Agents; Mammalian Cell; Membrane; Methods; Modality; Multi-Drug Resistance; Names; Natural regeneration; Outcome; Outpatients; Pathogenicity; Patients; Peptides; Phase; Process; Property; Quality Control; Repeat Surgery; Reporting; Resistance development; Safety; Shapes; Site; Skin; Skin Substitutes; Small Business Innovation Research Grant; Speed; Staphylococcal Infections; Staphylococcus aureus; Sterility; Structure; Testing; Thinness; TimeLine; Tissues; Toxic effect; Wound Infection; antimicrobial; bacterial resistance; base; biomaterial compatibility; chronic wound; cost; design; drug resistant bacteria; drug resistant pathogen; efficacy study; fighting; healing; improved; in vivo; innovation; methicillin resistant Staphylococcus aureus; multi-drug resistant pathogen; novel; pathogen; pre-clinical; preclinical safety; prevent; research clinical testing; resistant strain; safety study; scaffold; self assembly; skin wound; small molecule; technological innovation; tissue regeneration; tissue repair; tissue support frame; wound; wound care; wound closure; wound dressing; wound healing; wound treatment

Overview: This Fast track project aims to test the feasibility of a self-assembly peptide hydrogel for the treatment of wounds. Wound care is currently an expensive, multistep process in which wounds are treated with sequential products to 1) remove pathogens with antibiotics, 2) promote a healthy cellular environment through hydrogel application, and 3) close the wound with skin substitutes. Thus, the proposed product G4Derm is capable of simultaneously removing drug resistant pathogens through biophysical disruption of bacterial membranes, while promoting host tissue regeneration without added antibiotics or biologics. This product can be used in inpatient and outpatient wound care clinics to heal patients infected with drug resistant bacteria, and to reduce the 100,000 amputations performed each year in the US due to chronic wounds. Key words: tissue regeneration, infections, wound healing, biomaterials, antimicrobial Areas of application: tissue regeneration and repair, wound healing, infections Subtopic name: Biomedical (BM) Technologies Intellectual Merit: This Fast track proposal will generate 510(k) enabling data demonstrating safety and efficacy of G4Derm as an antimicrobial cell-scaffolding matrix that is simultaneously toxic to antibiotic- resistant bacterial strains, while remaining conducive to tissue regeneration. The current product uses a charge-based mechanism to lyse bacterial membranes upon contact and has a porous structure to promote cellular infiltration and cell attachment. Broader Impact: The broader impact of this Fast track proposal would be the development of a novel antimicrobial mechanism that can eliminate even drug-resistant bacterial strains from infected wounds. According to the Centers for Disease Control and Prevention Report, antibiotic-resistant bacteria will cause serious infections in 2 million Americans each year, resulting in an estimated 23,000 deaths annually. Our ability to fight antibiotic-resistant bacteria is diminishing, and the pipeline of new potential antibiotic drugs is growing lean. Only 9 new antibiotics have received FDA approval since 1998, of which only 2 of these incorporated novel mechanisms of action. Hence, the proposed product offers the unprecedented combination of simultaneous bacterial elimination while promoting tisue regeneration. As the antibacterial mechanism is biophysical, bacteria are unlikely to develop resistance to this product.

概述：本快速通道项目旨在测试自组装肽水凝胶的可行性