New approaches to improve thrombolysis in ischaemic stroke

改善缺血性中风溶栓的新方法

• 批准号: nhmrc : 1045756
• 负责人: Prof Arnan Mitchell
• 金额: $ 39.08万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-approaches-improve-ischaemic-stroke/111784
• 关键词: New; approaches; improve; thrombolysis; ischaemic

Ischaemic stroke is caused by the presence of a blood clot in the brain. The removal of these clots is achieved using an enzyme called tissue-type plasminogen activator (t-PA). While this agent is effective if given to patients within 4.5h of stroke onset, delayed administration can cause cerebral bleeding. This project is to understand how t-PA promotes these unwanted effects in the brain and to devise novel approaches to extend the time window of t-PA administration in these patients.

缺血性中风是由脑内存在血块引起的。这些凝块的清除是使用一种称为组织型纤溶酶原激活剂（t-PA）的酶来实现的。虽然这种药物在中风发作后4.5小时内给药是有效的，但延迟给药可能导致脑出血。该项目旨在了解t-PA如何促进大脑中这些不必要的影响，并设计新的方法来延长t-PA给药的时间窗。