Radionuclide Production and Radiochemistry Core Description Core

放射性核素生产和放射化学核心描述核心

基本信息

  • 批准号:
    10024891
  • 负责人:
  • 金额:
    $ 27.97万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-14 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY – RADIONUCLIDE PRODUCTION AND RADIOCHEMISTRY CORE 1 The Department of Medical Physics controls three different particle accelerator laboratories equipped with a variety of irradiation, radiochemistry, and radioanalytical equipment that will be used to investigate the symbiotic effects of targeted radiotherapy (TRT) and the immunological methodologies of Projects 1-4. The Cyclotron Laboratories’ principle site in the Wisconsin Institutes of Medical Research (WIMR) hosts a General Electric PETtrace 16-MeV proton / 8-MeV deuteron cyclotron surrounded by 4000 square feet of laboratory space used for radiochemical and accelerator research, as well as the routine production and international distribution of numerous radionuclides to a global customer base. The cyclotron laboratory infrastructure accommodates tens of Ci-quantities of radioactivity in automated processes using homemade and commercial equipment and is internationally established as a leader in solid, liquid, and gas phase accelerator targetry, primarily for positron- emission tomography (PET) radionuclide production. Spectroscopic/spectrometric analysis is accomplished with multiple high purity germanium detectors and a variety of configurable electronic equipment. Most recently, our research into alloy targetry for small, medical accelerators has enabled us to increase production of several radionuclides of interest to previously unprecedented levels. This laboratory currently produces 89Zr, 76/77Br, 86Y, 52gMn and more than two dozen other radionuclides on a weekly basis for local use and shipment to over 60 collaborators, colleagues, pharmaceutical companies, and globally premier research institutions in the US and abroad. The laboratory also hosts biosafety cabinets inside radiation areas for in vitro study of the unique radionuclides we produce, adjacent to the laboratory space of the Small Animal Imaging Core. Finally, the Department of Radiology recently finished construction of a GMP Radiopharmacy lab. The Radiopharmaceutical Production Facility (RPF) is situated within the WIMR complex across the hall from the cyclotron facility. It houses a new manufacturing area designed for the production of cGMP radiopharmaceuticals. This area is equipped with multiple hot cells and synthesis modules and includes multiple quality control instruments to accommodate segregation of clinical and preclinical production activities. A dispensing area designed in compliance with USP <797> has the capability to compound and distribute radiopharmaceuticals. Although clinical trials are not the aim of the PO1, we have the ability to rapidly translate the treatment paradigms discovered and developed within the PO1 to the clinical trial stage. The specific aim of the Radionuclide Production and Radiochemistry Core (RPRC) is to directly produce and supply pure imaging and therapy radionuclides and radiochemically synthesize all imaging/therapy/immunomodulatory doses of radiopharmaceuticals for use in the four PO1 Projects. This core will also be responsible for obtaining adequate amounts of alpha- and beta-emitting isotopes like Ac-225, Y-90 and Lu-177 from external commercial sources and/or the Oak Ridge National Laboratory.
项目摘要-放射性核素生产和放射化学堆芯1 医学物理系控制着三个不同的粒子加速器实验室, 各种辐照,放射化学和放射性分析设备,将用于调查共生 靶向放射治疗(TRT)的效果和项目1-4的免疫学方法。回旋加速器 位于威斯康星州医学研究所(WIMR)的实验室的主要地点拥有一个通用电气 PETtrace 16-MeV质子/ 8-MeV氘核回旋加速器,周围有4000平方英尺的实验室空间 用于放射化学和加速器研究,以及常规生产和国际分销 向全球客户群提供多种放射性核素。回旋加速器实验室的基础设施可容纳数十 在使用自制和商业设备的自动化过程中, 作为固体、液体和气相加速器靶向技术的领导者,在国际上享有盛誉,主要用于正电子- 发射断层扫描(PET)放射性核素生产。光谱/光谱分析是用 多个高纯锗探测器和各种可配置的电子设备。最近,我们 对用于小型医用加速器的合金靶的研究使我们能够增加几种 放射性核素的利益,以前所未有的水平。该实验室目前生产89 Zr,76/77 Br,86 Y, 52克锰和20多个其他放射性核素,供当地使用,并运往60多个国家和地区。 合作者、同事、制药公司和美国的全球一流研究机构, 国外该实验室还在辐射区域内设有生物安全柜,用于体外研究独特的 我们生产的放射性核素,毗邻小动物成像中心的实验室空间。最后 放射科最近完成了GMP放射性药物实验室的建设。放射性药物 生产设施(RPF)位于WIMR综合设施内,与回旋加速器设施隔一个大厅。它拥有 一个新的生产区,用于生产cGMP放射性药物。该区域配备了 具有多个热室和合成模块,并包括多个质量控制仪器, 分离临床和临床前生产活动。根据USP设计的配药区 <797>有能力合成和分配放射性药物虽然临床试验不是 我们有能力快速翻译在PO 1中发现和开发的治疗范例, PO 1进入临床试验阶段。放射性核素生产和放射化学堆芯的具体目标 (RPRC)是直接生产和供应纯成像和治疗放射性核素, 用于四个PO 1项目的所有成像/治疗/免疫调节剂量的放射性药物。这 核心还将负责获得足够数量的α和β发射同位素,如Ac-225, Y-90和Lu-177从外部商业来源和/或橡树岭国家实验室获得。

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Jonathan W Engle其他文献

Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection
  • DOI:
    10.1002/adma.201902956.
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
  • 作者:
    Dalong Ni;Hao Wei;Weiyu Chen;Qunqun Bao;Zachary T Rosenkrans;Todd E Barnhart;Carolina A Ferreira;Yanpu Wang;Heliang Yao;Tuanwei Sun;Dawei Jiang;Shiyong Li;Tianye Cao;Zhaofei Liu;Jonathan W Engle;Ping Hu;Xiaoli Lan;Weibo Cai
  • 通讯作者:
    Weibo Cai
Immuno-PET imaging of VEGFR-2 expression in prostate cancer with 89Zr-labeled ramucirumab
使用 89Zr 标记的雷莫芦单抗对前列腺癌中 VEGFR-2 表达进行免疫 PET 成像
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    5.3
  • 作者:
    Miao Li;Dawei Jiang;Todd E Barnhart;Tianye Cao;Jonathan W Engle;Weiyu Chen;Weibo Cai
  • 通讯作者:
    Weibo Cai
In vivo characterization of PD-L1 expression in breast cancer by immuno-PET with 89Zr-labeled avelumab
使用 89Zr 标记的 avelumab 通过免疫 PET 对乳腺癌中 PD-L1 表达进行体内表征
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    Miao Li;Emily B Ehlerding;Dawei Jiang;Todd E Barnhart;Weiyu Chen;Tianye Cao;Jonathan W Engle;Weibo Cai
  • 通讯作者:
    Weibo Cai

Jonathan W Engle的其他文献

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{{ truncateString('Jonathan W Engle', 18)}}的其他基金

Radionuclide Production and Radiochemistry Core Description Core
放射性核素生产和放射化学核心描述核心
  • 批准号:
    10416050
  • 财政年份:
    2020
  • 资助金额:
    $ 27.97万
  • 项目类别:
Radionuclide Production and Radiochemistry Core Description Core
放射性核素生产和放射化学核心描述核心
  • 批准号:
    10263251
  • 财政年份:
    2020
  • 资助金额:
    $ 27.97万
  • 项目类别:
Radionuclide Production and Radiochemistry Core Description Core
放射性核素生产和放射化学核心描述核心
  • 批准号:
    10672957
  • 财政年份:
    2020
  • 资助金额:
    $ 27.97万
  • 项目类别:

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