HSV 快速用户友好的 POC 诊断-猫眼课题宝

HSV 快速用户友好的 POC 诊断

批准号：

10005820

负责人：

Raymond Preston Stowe

金额：

$18.96万

依托单位：

MICROGEN, LLC

依托单位国家：

美国

项目类别：

财政年份：

2020

资助国家：

美国

项目状态：

已结题

起止时间：

2020-05-11 至 2022-04-30

来源：

https://reporter.nih.gov/project-details/10005820

关键词：

Antiviral Agents Archives Bedside Testings Biological Assay Buffers Clinical Clinical Pathology Collection Counseling Cytolysis Cytomegalovirus Cytomegalovirus Infections DNA Data Detection Development Diagnosis Diagnostic tests Disease Fetus Fluorescence Formulation Funding Genome Goals Gold Healthcare Systems Herpesvirus 1 Hospitals Human Human Herpesvirus 2 Human Resources Immunologics Infant Infection Infrastructure Label Laboratories Mediating Methods Morbidity - disease rate Neonatal Neonatology Neuraxis Nucleic Acid Amplification Tests Nucleic Acids Outcome Patients Performance Phase Process Reaction Reporter Reporting Reproducibility Research Research Design Risk Saliva Sampling Sensitivity and Specificity Simplexvirus Site Specimen Speed Spottings Standardization Surgical Flaps Survival Rate Swab Technology Testing Time Training United States National Institutes of Health Urine Vagina Validation Viral Virus Woman base biobank clinically relevant congenital cytomegalovirus cost design diagnosis standard field study fluorophore genital infection instrumentation internal control mortality neonatal patient neonate performance tests point of care point-of-care diagnostics prospective rapid diagnosis sample collection screening success transmission process user-friendly

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Project Summary There is an urgent need for a point-of-care (POC) test to detect HSV that could be used to identify at-risk patients, in particular neonatal patients. A rapid, point-of-care (POC) test that could detect HSV infections would: (1) allow for immediate counseling and additional specimen collection for confirmatory testing, and (2) avoid having to create new laboratory infrastructure for widespread biospecimen testing. We propose develop a POC test for rapid screening of HSV in clinical specimens. This technology will also result in a significant cost reduction as compared to hospital and clinical pathology laboratory tests. The goal of this project is to develop an inexpensive and rapid (<30 min from specimen to result) screening assay for HSV infections.

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