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Development of Anhedonia in High-Risk Adolescents

高危青少年快感缺失的发展

基本信息

批准号：
10006037
负责人：
Erika E Forbes
金额：
$ 50.37万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10006037
关键词：
Adolescence Adolescent Affective Age Anhedonia Behavior Behavioral Bipolar Disorder Brain Characteristics Communities Depressive disorder Development Diagnostic Dimensions Disease Exhibits Family history of Female First Degree Relative Functional Magnetic Resonance Imaging Functional disorder Goals Growth Internet Laboratories Learning Manic Measures Mental Depression Mental Health Modeling Mood Disorders Motivation National Institute of Mental Health Parents Participant Population Positive Valence Prevention approach Preventive Intervention Psychopathology Psychotic Disorders Recording of previous events Reporting Research Research Domain Criteria Rewards Risk Sampling Schedule Schizophrenia Severities Social Functioning Stimulus Symptoms System Techniques Testing Time Ventral Striatum Visit base depressive symptoms design experience high risk high risk population high-risk adolescents indexing innovation longitudinal design male neural correlate pleasure public health relevance recruit relating to nervous system response reward circuitry severe mental illness social

项目摘要

DESCRIPTION (provided by applicant): The proposed developmental psychopathology study examines the development of anhedonia during adolescence. Anhedonia, or difficulty experiencing pleasure in anticipation of or response to rewarding stimuli, is a coherent dimension within positive valence systems, has putative neural correlates in frontostriatal circuitry, and is relevant to several forms of serious psychopathology that emerge during adolescence. Anhedonia, a serious symptom, is likely to emerge during adolescence, and we propose that the development of anhedonia could precede the development of affective and schizophrenia-spectrum psychopathology. Specifically, the study examines developmental changes in subjective, neural, and behavioral aspects of anhedonia in 130 adolescents, age 13-17, who are either typically developing or have a first-degree relative with a history of depression, bipolar disorder, or schizophrenia-spectrum disorder. With the goal of understanding the development of anhedonia, the proposed study's aims include investigating (1) differences in anhedonia between high-risk and low-risk adolescents; (2) the development of anhedonia across adolescence; and (3) associations between anhedonia and depression, mania, and psychosis both cross-sectionally and longitudinally. Participants will complete 3 laboratory visits at annual intervals and 2 internet-based assessments, scheduled every 6 months between lab visits. Laboratory visits include self- and parent-report of anhedonia, psychopathology, and functioning; functional magnetic resonance imaging (fMRI) of frontostriatal function in response to monetary and social rewards; and behavioral tasks assessing reward motivation and reward learning. We will use longitudinal growth modeling to test our hypotheses. This study promises to advance mental health research by elucidating the development and pathophysiology of anhedonia, a dimension of psychopathology that occurs across disorders. Resulting understanding can inform the design of innovative, developmentally targeted prevention approaches.

描述（由申请人提供）：拟议的发展精神病理学研究检查青春期快感缺失的发展。快感缺乏，或在预期或对奖励刺激作出反应时难以体验到快乐，是正价系统内的一个连贯维度，在额纹状体回路中具有推定的神经相关性，并且与青春期出现的几种严重精神病理学形式相关。快感缺乏是一种严重的症状，很可能在青春期出现，我们认为快感缺乏的发展可能先于情感和精神分裂症谱系精神病理学的发展。具体来说，该研究调查了 130 名 13-17 岁青少年主观、神经和行为方面的快感缺乏的发展变化，这些青少年要么正在发育，要么有一级亲属有抑郁症、双相情感障碍或精神分裂症谱系障碍的病史。为了了解快感缺乏的发展，拟议研究的目的包括调查（1）高风险和低风险青少年之间快感缺乏的差异； (2) 整个青春期快感缺失的发展； (3) 快感缺失与抑郁、躁狂和精神病之间的横向和纵向关联。参与者将每年完成 3 次实验室访问，并在实验室访问之间每 6 个月完成 2 次基于互联网的评估。实验室访问包括自我报告和家长报告快感缺失、精神病理学和功能；功能性磁共振成像（fMRI）显示额纹状体对金钱和社会奖励的功能；以及评估奖励动机和奖励学习的行为任务。我们将使用纵向增长模型来检验我们的假设。这项研究有望通过阐明快感缺乏的发展和病理生理学来推进心理健康研究，快感缺乏是跨疾病发生的精神病理学的一个方面。由此产生的理解可以为创新的、有针对性的发展预防方法的设计提供信息。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Editorial: Missing the Pull of Life's Rewards? Attention Shifting and the Development of Depression.

社论：错过生活奖励的吸引力？

DOI：
10.1016/j.jaac.2018.07.907
发表时间：
2019
期刊：
Journal of the American Academy of Child and Adolescent Psychiatry
影响因子：
13.3
作者：
Forbes,ErikaE
通讯作者：
Forbes,ErikaE

Physical and social anhedonia in female adolescents: A factor analysis of self-report measures.

DOI：
10.1037/emo0000843
发表时间：
2022-12
期刊：
Emotion (Washington, D.C.)
影响因子：
0
作者：
Yang X;Casement MD;Keenan KE;Hipwell AE;Guyer AE;Forbes EE
通讯作者：
Forbes EE

Positive affect between close friends: Brain-behavior associations during adolescence.

亲密朋友之间的积极影响：青春期的大脑行为关联。

DOI：
10.1080/17470919.2019.1662840
发表时间：
2020
期刊：
Social neuroscience
影响因子：
2
作者：
Woods,BrittanyK;Forbes,ErikaE;Sheeber,LisaB;Allen,NicholasB;Silk,JenniferS;Jones,NeilP;Morgan,JudithK
通讯作者：
Morgan,JudithK

Adolescents' neural response to social reward and real-world emotional closeness and positive affect.