Role of Nucleolus and Ribosome Biogenesis in Coordinating Organism-wide Growth
核仁和核糖体生物发生在协调生物体生长中的作用
基本信息
- 批准号:10028723
- 负责人:
- 金额:$ 38.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:ArchitectureBiogenesisCaenorhabditis elegansCell NucleolusCell physiologyCellsChromosomesComplexDevelopmentDiseaseEmbryoEpigenetic ProcessFunctional disorderGene ExpressionGenetic ScreeningGenomeGrowthInvestigationKnowledgeLightMissionNull LymphocytesOrganismPathway interactionsResearchRibosomal DNARibosomal ProteinsRibosomesRoleSiteStructureSystemTissuesprograms
项目摘要
The overarching mission of my research program is to elucidate how the ribosomal DNA (rDNA) locus and
ribosome biogenesis connect to cellular processes to coordinate complex growth modes during organismal
development. The overall objectives of the current proposal are: (1) identification of cell non-autonomous factors
that provide a ribosome synthesis checkpoint to control organism-wide growth and (2) investigation of the
epigenetic function of nucleolus during organism development. First, we will identify regulators of cell non-
autonomous growth arrest in C. elegans by intensive forward genetic screens in strains that produce both wild-
type and homozygous ribosomal protein & rDNA null cells in precise lineages. To understand tissue specific
contributions to organism-wide growth, we will optimize a system that will reversibly block new ribosome
synthesis in a tissue and stage-specific way. Second, we will take advantage of viable C. elegans embryos that
lack multi-copy rDNA locus (hence the nucleolus structure) to investigate the fundamental roles of nucleolus in
genome organization and gene expression. We will identify and validate nucleolus associated domains. We will
then identify the global impact of nucleolus on chromosome architecture, genome organization and gene
expression. This study will (1) shed light onto the cell non-autonomous pathways that regulate organism-wide
growth coordination and (2) will identify the epigenetic roles of the nucleolus that are distinct from its essential
ribosome biogenesis function.
我的研究计划的首要任务是阐明核糖体DNA (rDNA)位点和
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Elif Sarinay Cenik 其他文献
Elif Sarinay Cenik 的其他文献
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{{ truncateString('Elif Sarinay Cenik ', 18)}}的其他基金
Role of Nucleolus and Ribosome Biogenesis in Coordinating Organism-wide Growth
核仁和核糖体生物发生在协调生物体生长中的作用
- 批准号:
10405480 - 财政年份:2020
- 资助金额:
$ 38.82万 - 项目类别:
Role of Nucleolus and Ribosome Biogenesis in Coordinating Organism-wide Growth
核仁和核糖体生物发生在协调生物体生长中的作用
- 批准号:
10204059 - 财政年份:2020
- 资助金额:
$ 38.82万 - 项目类别:
Role of Nucleolus and Ribosome Biogenesis in Coordinating Organism-wide Growth
核仁和核糖体生物发生在协调生物体生长中的作用
- 批准号:
10624967 - 财政年份:2020
- 资助金额:
$ 38.82万 - 项目类别:
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