Magnetic Resonance Analysis of Connective Tissue and Muscle

磁共振是一种很好的方式，详细的代谢和结构调查在人类受试者。我们对肌肉结构和功能测量之间的联系很感兴趣。通过与扩散相关的几种MR方法来探测肌肉结构，包括异常扩散测量和扩散张量成像。功能测量是指BLSA的测量，包括力量、肌肉质量和生物能量测量。我们在老年人群中发现了一个更大的肌节断裂的信号。我们还发现了脂肪组织对MR结果测量的影响，包括扩散指标。我们的大部分工作探索了减少脂肪组织影响的最佳策略，以便获得更有意义的肌肉结构指标。

MR is an excellent modality for detailed metabolic and structural investigations in human subjects. We areinterested in the link between muscle architecture and functional measures. Muscle architecture is probed by several MR methods related to diffusion, including anomalous diffusion measures and diffusion tensor imaging. Functional measures are those of the BLSA, and include force, muscle quality, and bioenergetic measures. We are finding a signal towards greater sarcomere fragmentation in the older populations. We have also uncovered the effect of adipose tissue on MR outcome measures, including diffusion metrics. Much of our work has explored optimal strategies for reducing the effect of adipose tissue so that more meaningful metrics of muscle structure may be obtained.