Magnetic Resonance Analysis of Connective Tissue and Muscle

结缔组织和肌肉的磁共振分析

• 批准号: 10008626
• 负责人: Richard Spencer
• 金额: $ 65.88万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10008626
• 关键词: Adipose tissue; Architecture; Bioenergetics; Cartilage; Connective Tissue; Diffusion; Diffusion Magnetic Resonance Imaging; Goals; Investigation; Laboratories; Link; Magnetic Resonance; Magnetic Resonance Imaging; Measures; Metabolic; Methods; Modality; Muscle; Musculoskeletal; Older Population; Outcome Measure; Sarcomeres; Signal Transduction; Structure; Tissues; Water; Work; human subject; improved; muscular structure; novel

MR is an excellent modality for detailed metabolic and structural investigations in human subjects. We areinterested in the link between muscle architecture and functional measures. Muscle architecture is probed by several MR methods related to diffusion, including anomalous diffusion measures and diffusion tensor imaging. Functional measures are those of the BLSA, and include force, muscle quality, and bioenergetic measures. We are finding a signal towards greater sarcomere fragmentation in the older populations. We have also uncovered the effect of adipose tissue on MR outcome measures, including diffusion metrics. Much of our work has explored optimal strategies for reducing the effect of adipose tissue so that more meaningful metrics of muscle structure may be obtained.

MR是一种用于人体受试者详细代谢和结构研究的优秀模式。 我们对肌肉结构和功能测量之间的联系很感兴趣。 肌肉结构的探讨与扩散，包括异常扩散措施和扩散张量成像的几种MR方法。 功能测量是BLSA的测量，包括力量、肌肉质量和生物能量测量。 我们发现老年人群中肌节碎裂程度更大的信号。 我们还发现了脂肪组织对MR结局指标的影响，包括扩散指标。 我们的大部分工作都在探索减少脂肪组织影响的最佳策略，以便获得更有意义的肌肉结构指标。