Magnetic Resonance Analysis of Connective Tissue and Muscle

磁共振是对受试者进行详细的代谢和结构研究的一种极好的方法。我们感兴趣的是肌肉结构和功能测量之间的联系。肌肉结构是通过几种与扩散相关的磁共振方法来探测的，包括异常扩散测量和扩散张量成像。功能测量是BLSA的那些，包括力量、肌肉质量和生物能量测量。我们发现了在老年人群中出现更多肌节碎裂的信号。我们还发现了脂肪组织对磁共振结果测量的影响，包括扩散测量。我们的许多工作探索了减少脂肪组织影响的最佳策略，以便获得更有意义的肌肉结构指标。

MR is an excellent modality for detailed metabolic and structural investigations in human subjects. We areinterested in the link between muscle architecture and functional measures. Muscle architecture is probed by several MR methods related to diffusion, including anomalous diffusion measures and diffusion tensor imaging. Functional measures are those of the BLSA, and include force, muscle quality, and bioenergetic measures. We are finding a signal towards greater sarcomere fragmentation in the older populations. We have also uncovered the effect of adipose tissue on MR outcome measures, including diffusion metrics. Much of our work has explored optimal strategies for reducing the effect of adipose tissue so that more meaningful metrics of muscle structure may be obtained.