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Respiratory health and cigar and pipe use in the NHLBI Pooled Cohorts Study

NHLBI 联合队列研究中的呼吸系统健康以及雪茄和烟斗的使用

基本信息

批准号：
10037747
负责人：
Elizabeth Oelsner
金额：
$ 24.3万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10037747
关键词：
Address Adult American Indians Asians Asthma Biological Markers CYP1A1 gene Cause of Death Cessation of life Chronic Chronic Obstructive Airway Disease Cigar Cigar Smoking Cigarette Cigarette Smoker Clinical Cohort Studies Consumption Data Data Pooling Decision Making Ethnic Origin Event General Population Gold Health Health Campaign Hispanics Hospitalization Interview Lung diseases Measures National Heart, Lung, and Blood Institute Outcome Patient Self-Report Pattern Persons Phenotype Physiological Poison Public Health Pulmonary Function Test/Forced Expiratory Volume 1 Questionnaires Race Relative Risks Research Respiratory physiology Risk Risk Factors Sampling Smoker Smoking Status Socioeconomic Status Spirometry Standardization Testing Time Tobacco use United States Woman Work airway obstruction base cigarette smoke cigarette smoking cigarette user clinically significant cohort data harmonization disability-adjusted life years electronic cigarette user environmental tobacco smoke exposure ethnic minority population experience follow-up improved men mortality pipe smoking population based preventable death respiratory respiratory health sex tobacco exposure tobacco products years of life lost

项目摘要

Summary/Abstract Chronic lower respiratory disease (CLRD), which includes chronic obstructive pulmonary disease (COPD) and asthma, is now the third leading cause of death globally. COPD, which is defined by airflow obstruction on spirometry, is a rising cause of years of life lost and disability-adjusted life years in the United States (US). Cigarette smoking, which accelerates lung function decline, is the major risk factor for CLRD. Noncigarette tobacco use, including cigars and pipes, is frequently perceived as low risk compared to cigarettes; however, concentrations of certain toxic chemicals from cigar and pipe smoking are comparable to – and, in some instances, higher than – those from cigarette smoking. This application will test if, like cigarette use, noncigarette tobacco use is associated with accelerated lung function decline and incident clinical CLRD events. We will test these hypotheses in the NHLBI Pooled Cohorts Study, which has harmonized and pooled data from 9 US general population-based cohorts that collected lung function data in 65,251 American Indian, Asian, Black, Hispanic and White adult men and women. Our investigative group has rigorously quality- controlled lung function measures across the cohorts using contemporary standards, yielding 105,696 valid spirometry exams. We have also developed and validated definitions for incident asthma- and COPD-related hospitalizations and deaths, of which there are presently >3,900 events over >340,000 person-years of follow- up. In Aim 1, we will harmonize cigar and pipe exposures across cohorts. These exposures were ascertained from standardized questionnaires and will be systematically evaluated, quality-controlled, and harmonized using the approach we have already successfully applied for cigarette tobacco exposures. We will use the harmonized data to classify our primary exposure, exclusive cigar/pipe use, defined as ever-use of cigar and/or pipe in lifelong never-cigarette smokers. We will also classify current cigar/pipe use, cumulative cigar/pipe exposure (cigar and pipe years), and current cigar/pipe intensity. In Aim 2, we will test associations between exclusive cigar/pipe use and longitudinal lung function, including decline in FEV1, FVC, and FEV1/FVC, as well as with incident airflow obstruction. In Aim 3, we will test associations with CLRD events. The proposed work will inform our understanding of the relative risks of cigar use and pipe use versus conventional cigarette use and establish the physiologic and clinical significance of cigar/pipe use with respect to chronic lower respiratory disease. These findings, which will be based upon gold standard phenotyping from a large US general population-based sample, will be suitable to inform regulatory decisions regarding cigar and pipe tobacco products.

摘要/文摘