Intraoperative imaging of macular hole repair to predict visual function outcomes
黄斑裂孔修复术中成像以预测视功能结果
基本信息
- 批准号:10037117
- 负责人:
- 金额:$ 36.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:4D ImagingAdoptionAdultAffectAmericanAnatomyAutomobile DrivingBlindnessClinicalClinical ResearchClinical TreatmentCorneaDataData SetDevelopmentDiagnosticDimensionsDiseaseEngineeringEyeFDA approvedFeedbackFoundationsGenerationsGoldImageImage-Guided SurgeryInner Limiting MembraneLeadLegalLinkMacular HoleMeasuresMethodsMicroscopeMicroscopyMotionOperative Surgical ProceduresOphthalmologyOptical Coherence TomographyOutcomePatientsPhotoreceptorsPostoperative PeriodPrevalenceProcessProgressive DiseaseRecoveryResearchResolutionRetinaRetinal PhotoreceptorsSamplingSeveritiesSpeedStructureSurgical ManagementSurgical SpecialtiesSurrogate MarkersSystemTechniquesTechnologyTestingThickTimeTissuesTractionTranslatingTraumaUnited StatesVisionVisual AcuityVisual FieldsVisual impairmentVisualizationVitrectomyaging populationbasebiomarker identificationclinical Diagnosisclinical decision-makingclinical diagnosticscostdata acquisitiondata archivedensitydigital imagingfollow-upfunctional outcomesimage guidedimaging biomarkerimaging studyin vivoinstrumentinstrumentationinterestmultimodalitynoveloutcome predictionprognosticprogramsrepairedstandard of caretomography
项目摘要
Low vision and blindness affect over 40 million Americans and have an estimated annual cost of $25 billion for
clinical diagnosis and treatment. The prevalence of visual impairment in adults 40 years and older in the United
States is above 3.5% and expected to increase markedly due to population aging. Many ocular diseases are
progressive and require surgical management at advanced stages, which involves precision manipulation of
delicate semi-transparent structures in the eye. Optical coherence tomography (OCT) has revolutionized
ophthalmic imaging by allowing for high-resolution noninvasive visualization of retinal microstructure and has
become the “gold standard” for clinical diagnostics. However, despite broad adoption of preoperative OCT for
surgical planning and predicting outcomes, postoperative functional outcomes may be highly variable. In macular
hole (MH) surgery, ~90% of patients achieve hole closure and anatomic normalization but as low as 27% of
patients achieve a best-corrected visual acuity of >20/40 (legal driving limit). We hypothesize that (1) structural
changes in the retina during MH repair, which are prognostic of postoperative visual function, result directly from
surgical intervention; (2) iOCT imaging of MH dynamics during surgery will enable quantification of image-based
biomarkers and identification of corresponding tissue-instrument interactions that lead to poor functional
outcomes; and (3) understanding the causal relationship between surgical manipulation and postoperative vision
will benefit clinical decision-making and novel surgical technique and intraoperative feedback mechanism
development for MH repair and other ocular diseases. Our collaborative program of engineers and clinicians will
perform foundational imaging studies to understand the casual effects that surgical maneuvers have on
postoperative vision recovery during MH repair. To overcome limitations of current-generation iOCT systems,
we have developed multimodal spectrally encoded coherence tomography and reflectometry (SECTR)
technologies that allows for simultaneous and intrinsically co-registered en face reflectance and cross-sectional
OCT imaging. SECTR uses concurrently acquired spectrally encoded reflectance (SER) en face and OCT cross-
sectional images to provide complementary spatial information in orthogonal dimensions and enable volumetric
registration and tracking. Segmentation of motion-corrected 4D OCT datasets in post-processing has enabled
retinal layer identification and quantification of tissue deformations resulting from surgical manipulation.
Automated tracking and 4D imaging of MH dynamics (AIM 1) provides unprecedent data on structural changes
resulting from surgical manipulation that have been shown to be predictive of postoperative functional outcomes
(AIM 2). In vivo iSECTR imaging during MH repair will be performed to understand the causal relationship
between surgical dynamics and postoperative visual function (AIM 3) and may lead to novel image-guided
surgical maneuvers. Technologies developed during this project will have broad applications in personalized
surgery, predicting outcomes, and image-guided feedback in a wide-range of surgical specialties.
视力低下和失明影响着4000多万美国人,估计每年为
临床诊断和治疗。美国40岁及以上成年人视力损害的患病率
各州的失业率在3.5%以上,预计由于人口老龄化,这一比例将大幅上升。许多眼病都是
进展性的,需要在晚期进行手术治疗,这涉及到精确的操作
眼睛里有精致的半透明结构。光学相干层析成像(OCT)已经带来了革命性的变化
通过允许高分辨率非侵入性可视化视网膜微结构进行眼科成像
成为临床诊断的“黄金标准”。然而,尽管广泛采用了术前OCT
手术计划和预测结果,术后功能结果可能是高度可变的。在黄斑部
孔(MH)手术,~90%的患者实现了孔闭合和解剖正常化,但只有27%的患者实现了孔闭合和解剖正常化
患者的最佳矫正视力为>;20/40(法定驾驶限制)。我们假设(1)结构性的
在MH修复过程中视网膜的变化,是术后视觉功能的预测,直接导致
手术干预;(2)术中MH动力学的iOCT成像将使基于图像的量化成为可能
导致功能不良的生物标志物和相应组织-器械相互作用的鉴定
结果;以及(3)了解手术操作和术后视力之间的因果关系
将有利于临床决策、新的手术技术和术中反馈机制
MH修复和其他眼科疾病的开发。我们的工程师和临床医生协作计划将
进行基础性的影像研究,以了解外科手术对
MH修补术中术后视力恢复情况。为了克服当前一代IOCT系统的局限性,
我们开发了多模式光谱编码相干层析成像和反射仪(SECTR)
允许同时和内在地共同配准面部反射和横截面的技术
OCT成像。SECTR使用面上和OCT十字同时采集的光谱编码反射率(SER)
截面图像可在垂直维度中提供互补的空间信息,并实现体积
注册和跟踪。在后处理中实现了运动校正的4D OCT数据集的分割
视网膜层识别和量化手术操作引起的组织变形。
MH动力学的自动跟踪和4D成像(AIM 1)提供了前所未有的结构变化数据
已被证明可以预测术后功能结果的外科操作的结果
(目标2)。将在MH修复期间进行活体iSECTR成像,以了解因果关系
手术动力学和术后视功能之间的关系(AIM 3),并可能导致新的图像引导
外科手术。在该项目中开发的技术将在个性化方面有广泛的应用
手术,预测结果,和图像引导的反馈,在广泛的外科专业。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Yuankai Kenny Tao其他文献
Yuankai Kenny Tao的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Yuankai Kenny Tao', 18)}}的其他基金
Intraoperative imaging of macular hole repair to predict visual function outcomes
黄斑裂孔修复术中成像以预测视功能结果
- 批准号:
10440331 - 财政年份:2020
- 资助金额:
$ 36.04万 - 项目类别:
Intraoperative imaging of macular hole repair to predict visual function outcomes
黄斑裂孔修复术中成像以预测视功能结果
- 批准号:
10653835 - 财政年份:2020
- 资助金额:
$ 36.04万 - 项目类别:
Intraoperative imaging of macular hole repair to predict visual function outcomes
黄斑裂孔修复术中成像以预测视功能结果
- 批准号:
10225463 - 财政年份:2020
- 资助金额:
$ 36.04万 - 项目类别:
Intraoperative Optical Coherence Tomography for Ophthalmic Surgical Guidance
用于眼科手术指导的术中光学相干断层扫描
- 批准号:
9803346 - 财政年份:2019
- 资助金额:
$ 36.04万 - 项目类别:
Intraoperative Optical Coherence Tomography for Ophthalmic Surgical Guidance
用于眼科手术指导的术中光学相干断层扫描
- 批准号:
10436823 - 财政年份:2019
- 资助金额:
$ 36.04万 - 项目类别:
Intraoperative Optical Coherence Tomography for Ophthalmic Surgical Guidance
用于眼科手术指导的术中光学相干断层扫描
- 批准号:
10002242 - 财政年份:2019
- 资助金额:
$ 36.04万 - 项目类别:
Intraoperative Optical Coherence Tomography for Ophthalmic Surgical Guidance
用于眼科手术指导的术中光学相干断层扫描
- 批准号:
10200070 - 财政年份:2019
- 资助金额:
$ 36.04万 - 项目类别:
Intraoperative Optical Coherence Tomography for Ophthalmic Surgical Guidance
用于眼科手术指导的术中光学相干断层扫描
- 批准号:
10654006 - 财政年份:2019
- 资助金额:
$ 36.04万 - 项目类别:
Wavefront Corrected Multimodal Optical Coherence and Two-Photon Microscopy for Ra
Ra 的波前校正多模态光学相干和双光子显微镜
- 批准号:
8366384 - 财政年份:2011
- 资助金额:
$ 36.04万 - 项目类别:
Wavefront Corrected Multimodal Optical Coherence and Two-Photon Microscopy for Ra
Ra 的波前校正多模态光学相干和双光子显微镜
- 批准号:
8255740 - 财政年份:2011
- 资助金额:
$ 36.04万 - 项目类别:
相似海外基金
Investigating the Adoption, Actual Usage, and Outcomes of Enterprise Collaboration Systems in Remote Work Settings.
调查远程工作环境中企业协作系统的采用、实际使用和结果。
- 批准号:
24K16436 - 财政年份:2024
- 资助金额:
$ 36.04万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
WELL-CALF: optimising accuracy for commercial adoption
WELL-CALF:优化商业采用的准确性
- 批准号:
10093543 - 财政年份:2024
- 资助金额:
$ 36.04万 - 项目类别:
Collaborative R&D
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 36.04万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 36.04万 - 项目类别:
EU-Funded
Assessing the Coordination of Electric Vehicle Adoption on Urban Energy Transition: A Geospatial Machine Learning Framework
评估电动汽车采用对城市能源转型的协调:地理空间机器学习框架
- 批准号:
24K20973 - 财政年份:2024
- 资助金额:
$ 36.04万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 36.04万 - 项目类别:
EU-Funded
De-Adoption Beta-Blockers in patients with stable ischemic heart disease without REduced LV ejection fraction, ongoing Ischemia, or Arrhythmias: a randomized Trial with blinded Endpoints (ABbreviate)
在没有左心室射血分数降低、持续性缺血或心律失常的稳定型缺血性心脏病患者中停用β受体阻滞剂:一项盲法终点随机试验(ABbreviate)
- 批准号:
481560 - 财政年份:2023
- 资助金额:
$ 36.04万 - 项目类别:
Operating Grants
Our focus for this project is accelerating the development and adoption of resource efficient solutions like fashion rental through technological advancement, addressing longer in use and reuse
我们该项目的重点是通过技术进步加快时装租赁等资源高效解决方案的开发和采用,解决更长的使用和重复使用问题
- 批准号:
10075502 - 财政年份:2023
- 资助金额:
$ 36.04万 - 项目类别:
Grant for R&D
Engage2innovate – Enhancing security solution design, adoption and impact through effective engagement and social innovation (E2i)
Engage2innovate — 通过有效参与和社会创新增强安全解决方案的设计、采用和影响 (E2i)
- 批准号:
10089082 - 财政年份:2023
- 资助金额:
$ 36.04万 - 项目类别:
EU-Funded
Collaborative Research: SCIPE: CyberInfrastructure Professionals InnoVating and brOadening the adoption of advanced Technologies (CI PIVOT)
合作研究:SCIPE:网络基础设施专业人员创新和扩大先进技术的采用 (CI PIVOT)
- 批准号:
2321091 - 财政年份:2023
- 资助金额:
$ 36.04万 - 项目类别:
Standard Grant