DCEG- Genotyping for epidemiology studies

DCEG-流行病学研究的基因分型

• 批准号: 10038402
• 负责人: LEONARD FREEDMAND
• 金额: $ 448.47万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-31 至 2020-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10038402
• 关键词: Affect; American Cancer Society; Area; Basic Science; Beta Carotene; Bioinformatics; Biological Assay; Cancer Burden; Caring; Cervical Cancer Screening; Colon; Communities; Custom; DNA; Data; Data Analyses; Data Quality; Data Set; Data Storage and Retrieval; Development; Disease; Disease Outcome; Division of Cancer Epidemiology and Genetics; Employment; Environmental Risk Factor; Epidemiologist; Experimental Designs; Family; Generations; Genes; Genetic; Genetic Markers; Genetic Variation; Genome Scan; Genomics; Genotype; Heritability; Human; Human Genetics; Human Genome; Human Microbiome; Human Papillomavirus; Image; Immunohistochemistry; Individual; Informatics; Information Management; Intramural Research Program; Laboratories; Laboratory Research; Lung; Malignant Neoplasms; Meta-Analysis; Molecular Epidemiology; Mutation; Normal tissue morphology; Nucleic Acids; Outcome; Ovarian; Phenotype; Population; Population Group; Predisposition; Prostate; Proteomics; Publications; Publishing; Research; Research Personnel; Research Support; Resources; Sampling; Scanning; Scientific Advances and Accomplishments; Scientist; Specimen; Statistical Methods; Support Groups; Surveys; Techniques; Technology; Technology Transfer; Tissues; Work; alpha Tocopherol; anticancer research; cancer genomics; cancer prevention; case control; clinically relevant; cohort; cost; cost effective; data access; data resource; database of Genotypes and Phenotypes; design; digital; digital pathology; epidemiology study; exome; exome sequencing; follow-up; genetic epidemiology; genetic variant; genome sequencing; genome wide association study; genome-wide; human genome sequencing; human genomics; interest; microbiome sequencing; molecular pathology; novel; rare variant; screening; technology research and development; tissue processing; tool; tumor

The Cancer Genomics Research (CGR) Laboratory was established to investigate the contribution of genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians, and basic research scientists in DCEG’s intramural research program, the CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. New work has begun in somatic research with the use of tumor/normal tissue nucleic acids for cross-platform comparisons in subjects of interest. A support group for molecular and digital pathology research within CGR has been added to support these efforts. CGR supports DCEG in all stages of cancer research from planning to publishing, including experimental design and project management, sample handling, genotyping and sequencing assay design and execution, tissue research support, development and implementation of bioinformatic pipelines, and downstream research and analytical support. These factors make CGR a unique collaborative center for NCI-driven scientific endeavors.

癌症基因组学研究（CGR）实验室的建立是为了研究遗传变异对癌症易感性和结果的贡献。CGR与DCEG内部研究项目的流行病学家、生物统计学家和基础研究科学家合作，提供了开展全基因组发现研究和有针对性的区域方法的能力，以确定各种癌症的遗传决定因素。新的工作已经开始在体细胞研究中使用肿瘤/正常组织核酸进行跨平台比较感兴趣的对象。在CGR内增加了一个分子和数字病理学研究支持小组来支持这些努力。CGR支持DCEG在癌症研究的所有阶段，从规划到发表，包括实验设计和项目管理，样品处理，基因分型和测序分析设计和执行，组织研究支持，生物信息管道的开发和实施，以及下游研究和分析支持。这些因素使CGR成为nci驱动的科学努力的独特协作中心。