DCEG-流行病学研究的基因分型-猫眼课题宝

DCEG-流行病学研究的基因分型

批准号：

10038402

负责人：

LEONARD FREEDMAND

金额：

$448.47万

依托单位：

LEIDOS BIOMEDICAL RESEARCH, INC.

依托单位国家：

美国

项目类别：

财政年份：

2019

资助国家：

美国

项目状态：

已结题

起止时间：

2019-08-31 至 2020-08-30

来源：

https://reporter.nih.gov/project-details/10038402

关键词：

Affect American Cancer Society Area Basic Science Beta Carotene Bioinformatics Biological Assay Cancer Burden Caring Cervical Cancer Screening Colon Communities Custom DNA Data Data Analyses Data Quality Data Set Data Storage and Retrieval Development Disease Disease Outcome Division of Cancer Epidemiology and Genetics Employment Environmental Risk Factor Epidemiologist Experimental Designs Family Generations Genes Genetic Genetic Markers Genetic Variation Genome Scan Genomics Genotype Heritability Human Human Genetics Human Genome Human Microbiome Human Papillomavirus Image Immunohistochemistry Individual Informatics Information Management Intramural Research Program Laboratories Laboratory Research Lung Malignant Neoplasms Meta-Analysis Molecular Epidemiology Mutation Normal tissue morphology Nucleic Acids Outcome Ovarian Phenotype Population Population Group Predisposition Prostate Proteomics Publications Publishing Research Research Personnel Research Support Resources Sampling Scanning Scientific Advances and Accomplishments Scientist Specimen Statistical Methods Support Groups Surveys Techniques Technology Technology Transfer Tissues Work alpha Tocopherol anticancer research cancer genomics cancer prevention case control clinically relevant cohort cost cost effective data access data resource database of Genotypes and Phenotypes design digital digital pathology epidemiology study exome exome sequencing follow-up genetic epidemiology genetic variant genome sequencing genome wide association study genome-wide human genome sequencing human genomics interest microbiome sequencing molecular pathology novel rare variant screening technology research and development tissue processing tool tumor

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The Cancer Genomics Research (CGR) Laboratory was established to investigate the contribution of genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians, and basic research scientists in DCEG’s intramural research program, the CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. New work has begun in somatic research with the use of tumor/normal tissue nucleic acids for cross-platform comparisons in subjects of interest. A support group for molecular and digital pathology research within CGR has been added to support these efforts. CGR supports DCEG in all stages of cancer research from planning to publishing, including experimental design and project management, sample handling, genotyping and sequencing assay design and execution, tissue research support, development and implementation of bioinformatic pipelines, and downstream research and analytical support. These factors make CGR a unique collaborative center for NCI-driven scientific endeavors.

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