BASE AWARD FOR USING RODENT BEHAVIORAL MODELS TO IDENTIFY SUBSTANCE ABUSE PHARMACOTHERAPIES

使用啮齿动物行为模型识别药物滥用药物治疗的基础奖

• 批准号: 10044665
• 负责人: MICHAEL FORSTER
• 金额: $ 92.12万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-20 至 2020-01-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10044665
• 关键词: Ames Assay; Award; Behavioral Model; Binding; Biological Assay; Computer Simulation; Contracts; Evaluation; Funding; In Vitro; Modeling; Motor Activity; Mus; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Preclinical Testing; Primates; Protocols documentation; Rattus; Relapse; Rodent; Rodent Model; Self Administration; Self Stimulation; Spottings; Standardization; Substance abuse problem; Support Contracts; Testing; Toxicology; base; drug discrimination; drug seeking behavior; in vitro testing; in vivo; interest; preference; safety testing

The purpose of this contract will be to provide testing capacity in the following rodent in vivo assays: mouse locomotor activity, rat drug discrimination, mouse conditioned place preference, and rat self-administration. These models are part of a larger pre-clinical testing hierarchy supported by separate contracts that fund the evaluation of compounds in the rat intracranial self-stimulation assay, various models of relapse to drug-seeking behavior, as well as the primate drug discrimination and self-administration models.

该合同的目的是提供以下啮齿动物体内试验的测试能力： 活性、大鼠药物辨别、小鼠条件性位置偏爱和大鼠自我给药。这些模型 这是一个更大的临床前测试层次结构的一部分，由单独的合同支持，这些合同为化合物的评估提供资金， 大鼠颅内自我刺激试验，各种药物寻求行为复发模型，以及灵长类动物 药物歧视和自我管理模式。