FY 13 Rodent Testing to Identify Pharma. for Substance Dependence

这项工作的目的是协助NIDA药物治疗和药物滥用的医学后果司（DPMCDA）成瘾治疗发现计划（ATDP）确定可用于治疗依赖的化学品。鉴定的目标化合物将包括那些可能通过促进戒断和/或通过防止滥用（例如，通过药理学或生理拮抗）而具有治疗作用的化合物。五个体内模型将用于提供必要的信息，以进一步考虑这些项目中的化合物：小鼠运动活动测试，大鼠药物识别测试，大鼠条件位置偏好测试，小鼠应激诱导的可卡因条件位置偏好增强测试和大鼠自我给药测试。

The objectives of this work are to assist the NIDA Division of Pharmacotherapies and Medical Consequences of Drug Abuse (DPMCDA) Addiction Treatment Discovery Program (ATDP) in the identification of chemicals useful for treatment of dependence. The compounds targeted for identification will include those that may have therapeutic effects via facilitation of abstinence and/or by preventing abuse (e.g., via pharmacological or physiological antagonism. Five in vivo models will be used to provide information necessary to advance compounds for further consideration within these programs: The Mouse Locomotor Activity test, Rat Drug Discrimination test, Rat Conditioned Place Preference test, Mouse Stress-Induced Potentiation of Cocaine Conditioned Place Preference test, and Rat Self-administration test.