FY 13 Rodent Testing to Identify Pharma. for Substance Dependence

13 财年啮齿动物测试以识别药物。

• 批准号: 8844833
• 负责人: MICHAEL FORSTER
• 金额: $ 85.49万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-04 至 2015-01-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8844833
• 关键词: Abstinence; Address; Animal Model; Biological Assay; Chemicals; Chemosensitization; Cocaine; Dependence; Development; Disease; Drug Industry; Drug abuse; Individual; Lead; Medical; Methamphetamine; Modeling; Motor Activity; Mus; National Institute of Drug Abuse; Neuraxis; Pharmaceutical Preparations; Pharmacotherapy; Physiological; Primates; Public Health; Rattus; Relapse; Rodent; Self Administration; Stress; Substance Addiction; Substance abuse problem; Support Contracts; Testing; Tetrahydrocannabinol; Therapeutic; Therapeutic Effect; Work; addiction; clinical efficacy; drug discrimination; efficacy testing; in vivo; in vivo Model; pre-clinical; preclinical evaluation; preference; prevent; programs

The objectives of this work are to assist the NIDA Division of Pharmacotherapies and Medical Consequences of Drug Abuse (DPMCDA) Addiction Treatment Discovery Program (ATDP) in the identification of chemicals useful for treatment of dependence. The compounds targeted for identification will include those that may have therapeutic effects via facilitation of abstinence and/or by preventing abuse (e.g., via pharmacological or physiological antagonism. Five in vivo models will be used to provide information necessary to advance compounds for further consideration within these programs: The Mouse Locomotor Activity test, Rat Drug Discrimination test, Rat Conditioned Place Preference test, Mouse Stress-Induced Potentiation of Cocaine Conditioned Place Preference test, and Rat Self-administration test.

这项工作的目的是协助NIDA药物治疗和药物滥用医疗后果司(DPMCDA)成瘾治疗发现计划(ATDP)识别对治疗依赖有用的化学物质。被确定为目标的化合物将包括那些可能通过促进戒断和/或通过防止滥用(例如，通过药理或生理拮抗)而具有治疗效果的化合物。将使用五个体内模型来提供必要的信息，以促进化合物在这些计划中的进一步考虑：小鼠运动活性测试、大鼠药物辨别测试、大鼠条件性位置偏爱测试、小鼠应激诱导的可卡因条件性位置偏爱测试和大鼠自我给药测试。