Gastric Electrical Slow Wave Functional MRI of the Human Brain

人脑胃电慢波功能 MRI

• 批准号: 10039901
• 负责人: JAMES J. PEKAR
• 金额: $ 44.59万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10039901
• 关键词: Abdomen; Accounting; Adult; Anorexia; Area; Biological Markers; Blood Glucose; Brain; Brain region; Clinical; Communication; Data; Development; Dorsal; Eating Disorders; Electrodes; Electroencephalography; Endocrine; Enteric Nervous System; Etiology; Fasting; Feedback; Frequencies; Functional Magnetic Resonance Imaging; Ganglia; Goals; Hour; Human; Imaging technology; Immune; Interstitial Cell of Cajal; Intestines; Lead; Magnetic Resonance Imaging; Magnetoencephalography; Measures; Methods; Modeling; Monitor; Motor Cortex; National Institute of Biomedical Imaging and Bioengineering; Nerve; Neuraxis; Neurons; Obesity; Pacemakers; Parasympathetic Nervous System; Participant; Pelvis; Peristalsis; Phase; Physiological; Population; Reporting; Research Project Grants; Rest; Scalp structure; Sensitivity and Specificity; Skin; Splanchnic Nerves; Stomach; Surface; Sympathetic Nervous System; Vagus nerve structure; Variant; Viscera; blood oxygen level dependent; cell motility; extrastriate; functional MRI scan; gut-brain axis; hemodynamics; imaging study; improved; neuroimaging; new technology; novel; novel marker; programs; relating to nervous system; transmission process; volunteer

Gastric Electrical Slow Wave Functional MRI of the Human Brain “Resting-state” fMRI (rsfMRI) is a noninvasive neuroimaging method that uses MRI acquisitions optimized for monitoring hemodynamic sequelae of task-evoked changes in brain activity (blood oxygenation level dependent or BOLD, task-fMRI) to observe activity in the brain “at rest”. The resulting MRI data manifest what are generally regarded as spontaneous fluctuations in intrinsic brain networks, allowing study of functional connectivity. Such phenomena may offer novel biomarkers for clinical populations, if they can be assessed without interference from other MRI effects and physiological phenomena. A recent report combining concurrent surface electrogastrography (EGG) and rsfMRI shows that the electrical slow wave (normogastric period of about 20 seconds), generated by interstitial cells of Cajal in the stomach, appears to drive activity in a brain “gastric network” including somato-motor cortices, dorsal precuneus, and the extrastriate body area. This observation that significant brain activity is not “spontaneous” in the sense of originating in the brain, but rather is driven by a “pacemaker” in the stomach, can be seen in two complementary ways: Either as a nuisance that confounds rsfMRI – suggesting the goal of modeling and reducing these effects – or as introducing a new technology for study of the embodied brain – suggesting the complementary goal of exploiting these effects. We will pursue three aims: 1. Estimate and reduce contributions of the slow gastric rhythm to established rsfMRI metrics. 2. Demonstrate whether controlling gastric state – fasted vs. fed – can reduce the impact of the gastric rhythm on established rsfMRI metrics. 3. Characterize the effects of gastric rhythm and state on the gastric network, and other brain regions. Accounting for brain activity driven by the basal gastric rhythm will enhance the ability to study spontaneous fluctuations in the brain's intrinsic networks, by allowing for the modeling of hitherto unexplained variability. Controlling gastric state has the potential to improve statistical power by reducing inter-session and inter-subject variance. Characterizing the effects of gastric rhythm and state on the brain will yield new measures of stomach/brain interactions, that could lead to novel studies in eating disorders ranging from anorexia to obesity.

人脑胃电慢波功能磁共振成像 “静息状态”fMRI（rsfMRI）是一种非侵入性神经成像方法，使用MRI采集优化， 监测任务诱发的脑活动变化（血氧水平）的血液动力学后遗症 依赖性或BOLD，任务功能磁共振成像），以观察大脑“休息”时的活动。由此产生的MRI数据表明， 通常被认为是内在大脑网络中的自发波动，允许研究功能性 连通性。如果能够对这些现象进行评估， 而不受其他MRI效应和生理现象的干扰。最近的一份报告结合了 同步表面胃电图（EGG）和rsfMRI显示，电慢波（正常胃 大约20秒的时间），由胃中的Cajal间质细胞产生，似乎驱动胃中的活动。 脑“胃网络”包括躯体运动皮质、背侧楔前叶和纹状体外体区。这 观察到重要的大脑活动不是起源于大脑的意义上的“自发”，而是 是由胃中的“起搏器”驱动的，可以从两个互补的方面来看： 混淆rsfMRI -建议建模和减少这些影响的目标-或作为引入一个新的 研究具身大脑的技术--这表明了利用这些效应的互补目标。 我们将追求三个目标：1。估计并减少胃慢节律对已建立的 rsfMRI指标。2.证明控制胃状态-空腹vs.进食-是否可以减少 胃节律的rsfMRI指标。3.描述胃节律和状态对胃排空的影响， 胃网络和其他大脑区域。考虑到基础胃节律驱动的大脑活动， 增强研究大脑内在网络中自发波动的能力， 迄今无法解释的变异性建模。控制胃状态有可能改善统计学 通过减少会话间和学科间差异来增强能力。描述胃节律的影响， 大脑的状态将产生胃/大脑相互作用的新措施，这可能导致新的研究， 从厌食到肥胖的饮食失调。