MRI SCANNER: AUTISM, MENTAL RETARDATION, MEMORY, BRAIN RADIATION IN CHILDREN

MRI 扫描仪：儿童自闭症、智力低下、记忆力、脑辐射

• 批准号: 7335117
• 负责人: JAMES J. PEKAR
• 金额: $ 5万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7335117
• 关键词: autism; brain; head; mammary gland; memory; mental retardation

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): We propose to acquire a 16-channel broadband digital radio-frequency (RF) system upgrade for the 3 Tesla MRI system at the P.M. Kirby Research Center at the Kennedy Krieger Institute. This upgrade includes multi-element receiver coils for brain, head and neck, infant brain, and breast. Our 3 T scanner currently has only six RF channels, which are not sufficient to use these new multi-element receiver coils. No 16-channel 3 T scanner is presently available at our institutions. Investigators at the Kennedy Krieger Institute, Johns Hopkins University, and the University of Maryland presently have 15 NIH-funded projects and 1 NSF-funded project with several aims that will strongly benefit from the improved technical capabilities offered by this upgrade. These investigators presently use the 3 T system in the F.M. Kirby Research Center for structural and functional MRI, quantitative physiological MRI, MR spectroscopy (MRS) and spectroscopic imaging (MRSI), and diffusion tensor imaging (DTI). The proposed upgrade will provide the following specific benefits for current users: 1) Compared to the 6-channel system currently in use, the 16-element head coil increases 1H MR sensitivity at the cortex by at least 27%, and reduces the noise-amplification penalty for high-rate SENSE by 77%. These primary advantages can be used to: a) better detect small fMRI signal changes; b) increase spatial resolution; c) increase temporal resolution (yield more data points per time in dynamic studies); d) reduce scan times (shorten scans); e) reduce spatial distortions. 2) The 16-element neuro-vascular coil allows integrated head and neck exams (i.e., combined scanning of the cervical spine and brain in single acquisitions), providing significant time savings. 3) The 8-element knee coil ("infant head coil") increases 1H MR sensitivity in infant (0-2 years old) cortex by ca. 40% (compared to the adult head coil now used). 4) The 7-element breast coil will allow breast MR studies to move from 1.5 T to 3 T, approximately doubling SNR. Furthermore, the 7-element coil will yield roughly an additional 20% SNR increase compared with 4- element coils, such as that now used at 1.5 T. The increases in sensitivity yielded by these multi-element coils are highly significant. For instance, the 27% increase in cortical sensitivity from the 16-element head coil compares to an increase in field strength to about 4 T, and would permit at least a 38% reduction in acquisition time, crucial for the special populations of children (e.g., autism; ADHD) studied at Kennedy Krieger Institute. The 3 T 16-channel digital RF upgrade is essential for continued high-quality state-of-the-art research at our institutions and for the national facilities provided by our Research Resource.

该子项目是利用 NIH/NCRR 资助的共享仪器补助金提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是资助机构，不一定是研究者的机构。描述（由申请人提供）：我们建议在下午为 3 Tesla MRI 系统购买 16 通道宽带数字射频 (RF) 系统升级。肯尼迪克里格研究所的柯比研究中心。此次升级包括用于大脑、头颈、婴儿大脑和乳房的多元件接收线圈。我们的 3 T 扫描仪目前只有 6 个射频通道，不足以使用这些新的多元件接收线圈。我们的机构目前没有 16 通道 3 T 扫描仪。 肯尼迪克里格研究所、约翰霍普金斯大学和马里兰大学的研究人员目前有 15 个 NIH 资助的项目和 1 个 NSF 资助的项目，其多个目标将极大地受益于此次升级所提供的改进的技术能力。这些研究人员目前在 F.M. 中使用 3 T 系统。柯比研究中心的结构和功能 MRI、定量生理 MRI、磁共振波谱 (MRS) 和波谱成像 (MRSI) 以及扩散张量成像 (DTI)。 拟议的升级将为当前用户提供以下具体好处：1）与目前使用的 6 通道系统相比，16 元件头部线圈将皮层的 1H MR 灵敏度提高至少 27%，并将高速率 SENSE 的噪声放大损失降低 77%。这些主要优点可用于： a) 更好地检测小的 fMRI 信号变化； b) 提高​​空间分辨率； c) 提高时间分辨率（动态研究中每次产生更多数据点）； d) 减少扫描时间（缩短扫描次数）； e) 减少空间扭曲。 2) 16 元件神经血管线圈可实现头颈综合检查（即在单次采集中对颈椎和大脑进行组合扫描），从而节省大量时间。 3) 8 元件膝盖线圈（“婴儿头部线圈”）可将婴儿（0-2 岁）皮质的 1H MR 敏感性提高约 10%。 40%（与现在使用的成人头部线圈相比）。 4) 7 元件乳腺线圈将使乳腺 MR 研究从 1.5 T 提高到 3 T，大约使 SNR 增加一倍。此外，与 4 元件线圈（例如目前在 1.5 T 下使用的线圈）相比，7 元件线圈的 SNR 大约会额外增加 20%。这些多元件线圈带来的灵敏度提升非常显着。例如，与场强增加到约 4 T 相比，16 元件头部线圈的皮质敏感性增加了 27%，并且可以使采集时间至少减少 38%，这对于肯尼迪克里格研究所研究的特殊儿童群体（例如自闭症、多动症）至关重要。 3 T 16 通道数字射频升级对于我们机构的持续高质量最先进研究以及我们的研究资源提供的国家设施至关重要。