Development of An Optoelectronically Active Bioink

项目摘要 作为最重要的器官之一，心脏就像一个强大的生物泵，能主动输送/循环。 通过血管系统流入/流出所有其他器官的血液。它一直是治疗和治疗癌症的重点 通过组织工程学和再生医学损伤或患病的心脏。经过多年的磨练 努力，心脏组织工程领域在构建功能材料方面取得了巨大的进步 心脏组织在很大程度上概括了心脏的生物学，但仍然存在挑战。这个 心肌细胞的排列及其组织成束的特征是自发和 同步收缩使生物相关心脏组织的发育复杂化。成熟和 心肌细胞的收缩是另一个主要障碍。这一拟议项目的总体目标是 开发一种光电活性生物墨水，使其能够有效地成熟和按需调整 通过自由和远程光照明对心脏组织进行生物打印，以解决未检测到的 迫切需要生物打印具有嵌入的远程刺激/起搏功能的心脏组织。生物墨水将会 允许通过集成超薄颗粒形式的μ太阳能电池来实现光能的电转换 用于原位光诱导电刺激，其中颗粒也将被设计为可生物降解到 与组织成熟度相匹配。

Project Summary As one of the most vital organs, the heart functions as a potent biological pump that actively delivers/recycles the blood towards/from all other organs through the vascular system. It has always been a focus in healing an injured or diseased heart through tissue engineering and regenerative medicine. With many years of endeavors, the field of cardiac tissue engineering has seen tremendous progress in fabricating functional cardiac tissues that to a great extent recapitulate the biology of the heart, but challenges remain. The alignment of cardiomyocytes and their organization into bundles characterized by spontaneous and synchronous contraction complicate the development of biologically relevant cardiac tissues. Maturation and contraction of the cardiomyocytes poses another major obstacle. The overall goal of this proposed project is to develop an optoelectronically active bioink that will enable effective maturation and on-demand pacing of the bioprinted cardiac tissues through untethered and remote photo-illumination, in order to address the unmet urgent needs in bioprinting cardiac tissues with embedded, remote stimulation/pacing functions. The bioink will allow for electrical conversion of photoenergy through integration of μ-solar cells in the form of ultra-thin pellets for in situ photo induced electrical stimulation, where the pellets will also be designed to be biodegradable to match the rate of tissue maturation.