New Photo-Acoustic Imaging Process in Fetal Monitoring to Dramatically Reduce Brain Injuries in Newborns

胎儿监测中的新光声成像流程可显着减少新生儿脑损伤

• 批准号: 10010328
• 负责人: ChenChia Wang
• 金额: $ 15万
• 依托单位: BRIMROSE TECHNOLOGY CORPORATION
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10010328
• 关键词: Acoustics; Adult; Aluminum; Animals; Asphyxia; Auscultation; Biological; Birth; Blood; Brain; Brain Injuries; Caregivers; Cerebral Palsy; Cerebral cortex; Cerebral perfusion pressure; Cerebrum; Cesarean section; Clinical; Communities; Detection; Development; Devices; Discipline of Nursing; Discipline of obstetrics; Drug or chemical Tissue Distribution; Early Diagnosis; Early Intervention; Early treatment; Electricity; Elements; Engineering; Evaluation; Fetal Heart Rate; Fetal Monitoring; Fetus; Gases; Goals; Hemoglobin; Hybrids; Hypoxia; Imaging Device; Impairment; Incidence; Infant; Intention; Intervention; Ischemia; Laboratories; Lasers; Legal patent; Light; Live Birth; Machine Learning; Maternal-fetal medicine; Measurement; Measures; Medical; Medicine; Metabolic acidosis; Methods; Modeling; Monitor; Nature; Neodymium; Neonatal; Neurologic; Newborn Infant; Noise; Optics; Oxyhemoglobin; Pathway interactions; Perinatal anoxic ischemic brain injury; Phase; Physiologic pulse; Physiology; Preparation; Procedures; Process; Reporting; Research; Research Personnel; Resolution; Role; Safety; Sagittal Sinus; Scalp structure; Sensitivity and Specificity; Signal Transduction; Small Business Innovation Research Grant; Source; Specificity; Structure of fontanel of skull; System; Technology; Therapeutic; Time; Tissues; Translations; Ultrasonic wave; Ultrasonography; Universities; Validation; Veins; Venous; Yttrium; absorption; base; bone; cerebral oxygenation; cerebral vein; chromophore; commercialization; contrast imaging; cost; cranium; detector; disability; energy density; falls; fetal; fetal brain injury; fetus at risk; global health; hazard; heart rate monitor; imaging system; improved; in silico; in vivo; innovation; instrument; intrapartum; light scattering; machine learning method; microphone; miniaturize; mortality; natural hypothermia; neonatal brain; neonatal hypoxic-ischemic brain injury; novel; photoacoustic imaging; prevent; prototype; sensor; simulation; sound; temporal measurement; virtual

PROJECT SUMMARY Summary The Brimrose Technology Corporation and Johns Hopkins University are forming a powerful new team to make a new instrument that has the potential to dramatically reduce a major global health problem–perinatal hypoxic- ischemic encephalopathy (HIE)–by enabling early detection during labor. HIE caused by asphyxia is a leading cause of infant fatalities as well as a source of cerebral palsy and other long-term severe neurologic impairments. The medical community has been limited in early diagnosis of HIE because current fetal heart rate monitoring has poor specificity. If identified early, HIE can be treated effectively with therapeutic hypothermia. We are proposing a fetal photoacoustic monitoring system that measures oxyhemoglobin saturation of the sagittal sinus vein draining the fetal cerebral cortex during labor. Sagittal sinus oxyhemoglobin saturation decreases to very low levels when placental gas exchange is impaired (hypoxia) and/or when fetal cerebral perfusion pressure falls (ischemia). The photoacoustic instrument transmits light through the open fontanelle or bone and into cerebral veins and tissue where ultrasound waves are generated. Using near- infrared incident light at discrete wavelengths that are absorbed preferentially by oxy- and deoxy-hemoglobin, ultrasound detected on the fetal scalp at each wavelength can estimate oxyhemoglobin saturation. Brimrose has constructed a novel ultrasound detection technology with sensitivity orders of magnitude greater than the current best-use piezo-electric sensors. This will permit the use of low-power LED light sources rather than cumbersome laser lights now employed, thereby avoiding safety goggle use and promoting greater deployment. The Hopkins team has already validated the ability of a standard photoacoustic system to accurately estimate sagittal sinus oxyhemoglobin saturation through the skull of newborn piglets. The purpose of Phase I is to demonstrate the feasibility of using safe, low power LED light sources with the new ultrasensitive ultrasound sensor to detect critically low sagittal sinus oxyhemoglobin saturation when oxygenation is manipulated. The platform will be based on in-silico simulation to optimize the acoustic and optical pathways for the skull and brain. Real-time measurements on a time scale of seconds will inform the obstetric caregiver of dynamic fluctuations of brain oxygenation during contractions. The Phase II goal is to make a miniaturized photoacoustic device prototype that can report on fetal brain oxygenation. We believe the resulting instrument will provide early detection brain HI with greater specificity and sensitivity, enabling early intervention and treatment and is potentially transferrable to a commercial model for manufacture.

项目概要 概括 Brimrose 科技公司和约翰霍普金斯大学正在组建一个强大的新团队，以制造 一种新仪器有可能大大减少全球主要健康问题——围产期缺氧—— 缺血性脑病（HIE）——通过在分娩过程中进行早期检测。窒息引起的 HIE 是主要的 婴儿死亡的原因以及脑瘫和其他长期严重神经系统疾病的根源 损伤。由于目前的胎儿心脏状况，医学界对 HIE 的早期诊断受到限制。 速率监测的特异性较差。如果及早发现，HIE 可以通过治疗得到有效治疗 低温。我们提出了一种测量氧合血红蛋白的胎儿光声监测系统 分娩时引流胎儿大脑皮层的矢状窦静脉饱和度。矢状窦氧合血红蛋白 当胎盘气体交换受损（缺氧）和/或胎儿时，饱和度会降至非常低的水平 脑灌注压下降（缺血）。光声仪器通过开放的光传输 囟门或骨头进入脑静脉和产生超声波的组织。使用近 离散波长的红外入射光优先被氧合血红蛋白和脱氧血红蛋白吸收， 在胎儿头皮上检测到的每个波长的超声波可以估计氧合血红蛋白饱和度。布里姆罗斯 构建了一种新颖的超声波检测技术，其灵敏度比现有技术高出几个数量级 当前最好用的压电传感器。这将允许使用低功率 LED 光源，而不是 现在使用笨重的激光灯，从而避免使用安全护目镜并促进更多 部署。霍普金斯大学团队已经验证了标准光声系统的能力 通过新生仔猪的头骨准确估计矢状窦氧合血红蛋白饱和度。目的 第一阶段的目标是展示使用安全、低功耗 LED 光源和新型光源的可行性 超灵敏超声波传感器可检测矢状窦氧合血红蛋白饱和度极低的情况 氧合被操纵。该平台将基于计算机模拟来优化声学和 头骨和大脑的光学通路。以秒为单位的实时测量将告知 产科护理人员宫缩期间大脑氧合的动态波动。第二阶段的目标是 制作一个微型光声设备原型，可以报告胎儿大脑的氧合情况。我们相信 由此产生的仪器将提供具有更高特异性和灵敏度的早期检测大脑 HI，从而实现早期检测 干预和治疗，并有可能转化为商业生产模式。

项目成果

Ultrasound Signal Detection with Multi-bounce Laser Microphone.

• DOI: 10.1109/ius46767.2020.9251499
• 发表时间: 2020-09
• 期刊: IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium
• 作者: Wan Q;Wang C;Xu K;Kang J;Wu Y;Trivedi SB;Gehlbach P;Boctor E
• 通讯作者: Boctor E