A Wearable Optical Imaging System for Daily Monitoring of Prefrontal Activity in ADHD

用于日常监测多动症患者前额叶活动的可穿戴光学成像系统

• 批准号: 10043220
• 负责人: Audrey Kynsella Bowden
• 金额: $ 44.31万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10043220
• 关键词: Adherence; Affect; Agreement; Attention deficit hyperactivity disorder; Behavior; Behavioral; Biological; Biological Markers; Brain; Brain Diseases; Brain Mapping; Brain imaging; Cellular Phone; Child; Clinic; Clinical; Cohort Studies; Computer software; Data; Data Collection; Detection; Diagnosis; Disease; Early Diagnosis; Electroencephalography; Functional Magnetic Resonance Imaging; Gold; Health; Home environment; Hour; Human; Imaging technology; Individual; Investments; Knowledge; Magnetic Resonance Imaging; Mainstreaming; Maps; Measurement; Measures; Medicine; Mental Health; Mental disorders; Modeling; Monitor; Morphologic artifacts; Movement; National Institute of Mental Health; Near-Infrared Spectroscopy; Neurocognitive; Noise; Optics; Patients; Pattern; Prefrontal Cortex; Psychiatry; Reproducibility of Results; Research; Research Personnel; Rest; Sampling; Signal Transduction; Site; Symptoms; System; Testing; Translations; Wireless Technology; base; brain dysfunction; clinical Diagnosis; clinical translation; cognitive task; cost; disorder control; disorder subtype; executive function; imaging biomarker; imaging system; individual patient; innovation; insight; neuroimaging; neuropathology; neuropsychiatry; novel; operation; optical imaging; patient variability; portability; prototype; treatment response

PROJECT SUMMARY Over the past decade, the National Institute of Mental Health (NIMH) has invested several billion dollars for large-scale, multi-site, functional MRI (fMRI) cohort studies in pursuit of brain markers for mental illness, yet clinical translation of fMRI for diagnosis of mental illness is plagued with many challenges. Chief among them is the lack of reproducibility of findings at the individual level due to the suboptimal measurement reliability of short-quantity (<10 min) fMRI recordings. Research suggests that collecting hours – not minutes – of data per individual patient may be needed to fulfill the clinical promise of functional neuroimaging, but issues of cost, compliance and the ecological validity of tested paradigms render such fMRI studies impractical in patients with psychiatric conditions and contribute to the huge gap in the clinical utility of imaging technologies for mental health. To bridge the gap in translation of functional neuroimaging in clinical neuropsychiatry, we propose to optimize, test and validate a wearable imaging system based on functional near infrared spectroscopy (fNIRS) that is low-cost, accessible, reliable, and can be used at home for collecting highly- sampled brain activity in patients with mental illness, using the prefrontal activity of children with Attention Deficit Hyperactivity Disorder (ADHD) as a model illness to test the feasibility of this innovative paradigm. Compared with fMRI, fNIRS is inexpensive, portable, and more tolerant to subject movement, allowing for measurement of brain activity in naturalistic situations. Our central hypothesis is that collecting highly-sampled individual data will allow us to detect patterns of brain activity that can be reliably replicated at the individual level and that predict behavioral and clinical symptoms. A wealth of fMRI and fNIRS data already demonstrate (a) consistent hypoactivation in the prefrontal circuit in ADHD during executive functioning tasks and (b) association between hypoactivity in the prefrontal circuit in ADHD and behavioral and clinical symptoms. We will collect highly-sampled fNIRS data on the prefrontal activity of 30 children with ADHD and 30 typically developing controls. Data will be collected daily over three weeks while subjects are at rest and/or performing cognitive tasks on a smart-phone. Our interdisciplinary, multi-institutional team has already developed a very low-cost (<$100) prototype wearable, wireless fNIRS system for monitoring activity of the prefrontal cortex that we will refine (Aim 1) and deploy (Aim 2) through this proposal. Aim 1: Optimize a prototype wearable, wireless, multi-channel, smart-phone operated optical imaging system for regular monitoring of prefrontal activity at home. Aim 2: Test and validate the proposed system for reliable monitoring of prefrontal activity in children with ADHD. Successful completion of this first-of-a-kind study will help shift the current paradigm away from in-lab, small-quantity neuroimaging and pave the way for developing effective biomarkers that can be used clinically for diagnosis and early detection of mental disorders, monitoring the response to treatment.

项目总结

项目成果

Decoding the heterogeneity of Alzheimer's disease diagnosis and progression using multilayer networks.

• DOI: 10.1038/s41380-022-01886-z
• 发表时间: 2023-06
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Avelar-Pereira, Barbara;Belloy, Michael E.;O'Hara, Ruth;Hosseini, S. M. Hadi
• 通讯作者: Hosseini, S. M. Hadi

Functional near-infrared spectroscopy in developmental psychiatry: a review of attention deficit hyperactivity disorder.

• DOI: 10.1007/s00406-021-01288-2
• 发表时间: 2022-03
• 期刊: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
• 影响因子: 4.7
• 作者: Gosse, Louisa K.;Bell, Sarah W.;Hosseini, S. M. Hadi
• 通讯作者: Hosseini, S. M. Hadi

The Effect of Baseline Performance and Age on Cognitive Training Improvements in Older Adults: A Qualitative Review.

• DOI: 10.14283/jpad.2020.55
• 发表时间: 2021
• 期刊: The journal of prevention of Alzheimer's disease
• 作者: Shaw JS;Hosseini SMH
• 通讯作者: Hosseini SMH

A low-cost, wearable, do-it-yourself functional near-infrared spectroscopy (DIY-fNIRS) headband.

低成本、可穿戴、DIY 功能性近红外光谱 (DIY-fNIRS) 头带。

• DOI: 10.1016/j.ohx.2021.e00204
• 发表时间: 2021
• 期刊: HardwareX
• 影响因子: 2.2
• 作者: Tsow,Francis;Kumar,Anupam;Hosseini,SmHadi;Bowden,Audrey
• 通讯作者: Bowden,Audrey

Quantitative measurement of macromolecular tissue properties in white and gray matter in healthy aging and amnestic MCI.

• DOI: 10.1016/j.neuroimage.2021.118161
• 发表时间: 2021-08-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Gozdas E;Fingerhut H;Wu H;Bruno JL;Dacorro L;Jo B;O'Hara R;Reiss AL;Hosseini SMH
• 通讯作者: Hosseini SMH