A Wearable Optical Imaging System for Daily Monitoring of Prefrontal Activity in ADHD

用于日常监测多动症患者前额叶活动的可穿戴光学成像系统

• 批准号: 10043220
• 负责人: Audrey Kynsella Bowden
• 金额: $ 44.31万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10043220
• 关键词: Adherence; Affect; Agreement; Attention deficit hyperactivity disorder; Behavior; Behavioral; Biological; Biological Markers; Brain; Brain Diseases; Brain Mapping; Brain imaging; Cellular Phone; Child; Clinic; Clinical; Cohort Studies; Computer software; Data; Data Collection; Detection; Diagnosis; Disease; Early Diagnosis; Electroencephalography; Functional Magnetic Resonance Imaging; Gold; Health; Home environment; Hour; Human; Imaging technology; Individual; Investments; Knowledge; Magnetic Resonance Imaging; Mainstreaming; Maps; Measurement; Measures; Medicine; Mental Health; Mental disorders; Modeling; Monitor; Morphologic artifacts; Movement; National Institute of Mental Health; Near-Infrared Spectroscopy; Neurocognitive; Noise; Optics; Patients; Pattern; Prefrontal Cortex; Psychiatry; Reproducibility of Results; Research; Research Personnel; Rest; Sampling; Signal Transduction; Site; Symptoms; System; Testing; Translations; Wireless Technology; base; brain dysfunction; clinical Diagnosis; clinical translation; cognitive task; cost; disorder control; disorder subtype; executive function; imaging biomarker; imaging system; individual patient; innovation; insight; neuroimaging; neuropathology; neuropsychiatry; novel; operation; optical imaging; patient variability; portability; prototype; treatment response

PROJECT SUMMARY Over the past decade, the National Institute of Mental Health (NIMH) has invested several billion dollars for large-scale, multi-site, functional MRI (fMRI) cohort studies in pursuit of brain markers for mental illness, yet clinical translation of fMRI for diagnosis of mental illness is plagued with many challenges. Chief among them is the lack of reproducibility of findings at the individual level due to the suboptimal measurement reliability of short-quantity (<10 min) fMRI recordings. Research suggests that collecting hours – not minutes – of data per individual patient may be needed to fulfill the clinical promise of functional neuroimaging, but issues of cost, compliance and the ecological validity of tested paradigms render such fMRI studies impractical in patients with psychiatric conditions and contribute to the huge gap in the clinical utility of imaging technologies for mental health. To bridge the gap in translation of functional neuroimaging in clinical neuropsychiatry, we propose to optimize, test and validate a wearable imaging system based on functional near infrared spectroscopy (fNIRS) that is low-cost, accessible, reliable, and can be used at home for collecting highly- sampled brain activity in patients with mental illness, using the prefrontal activity of children with Attention Deficit Hyperactivity Disorder (ADHD) as a model illness to test the feasibility of this innovative paradigm. Compared with fMRI, fNIRS is inexpensive, portable, and more tolerant to subject movement, allowing for measurement of brain activity in naturalistic situations. Our central hypothesis is that collecting highly-sampled individual data will allow us to detect patterns of brain activity that can be reliably replicated at the individual level and that predict behavioral and clinical symptoms. A wealth of fMRI and fNIRS data already demonstrate (a) consistent hypoactivation in the prefrontal circuit in ADHD during executive functioning tasks and (b) association between hypoactivity in the prefrontal circuit in ADHD and behavioral and clinical symptoms. We will collect highly-sampled fNIRS data on the prefrontal activity of 30 children with ADHD and 30 typically developing controls. Data will be collected daily over three weeks while subjects are at rest and/or performing cognitive tasks on a smart-phone. Our interdisciplinary, multi-institutional team has already developed a very low-cost (<$100) prototype wearable, wireless fNIRS system for monitoring activity of the prefrontal cortex that we will refine (Aim 1) and deploy (Aim 2) through this proposal. Aim 1: Optimize a prototype wearable, wireless, multi-channel, smart-phone operated optical imaging system for regular monitoring of prefrontal activity at home. Aim 2: Test and validate the proposed system for reliable monitoring of prefrontal activity in children with ADHD. Successful completion of this first-of-a-kind study will help shift the current paradigm away from in-lab, small-quantity neuroimaging and pave the way for developing effective biomarkers that can be used clinically for diagnosis and early detection of mental disorders, monitoring the response to treatment.

项目摘要 在过去的十年里，国家精神卫生研究所（NIMH）已经投资了数十亿美元， 大规模、多地点、功能性磁共振成像（fMRI）队列研究旨在寻找精神疾病的大脑标志物， 用于诊断精神疾病的功能磁共振成像的临床转化受到许多挑战的困扰。其中最主要 是由于次优测量可靠性，在个体水平上缺乏结果的再现性， 短量（<10分钟）fMRI记录。研究表明，每小时（而不是每分钟）收集数据 可能需要个体患者来实现功能性神经成像的临床承诺，但是成本问题， 顺应性和生态有效性的测试范例，使这样的功能磁共振成像研究在病人不切实际 与精神疾病，并有助于成像技术的临床应用的巨大差距， 心理健康为了弥补临床神经精神病学中功能性神经影像学翻译差距，我们 提出优化、测试和验证基于功能性近红外的可穿戴成像系统 光谱（fNIRS）是低成本，可访问的，可靠的，可以在家里用于收集高度- 精神疾病患者大脑活动的抽样，使用注意力儿童的前额叶活动 我们以多动症（ADHD）作为疾病模型，以测试这种创新模式的可行性。 与fMRI相比，fNIRS价格低廉，便携，对受试者运动更宽容，允许 在自然环境下测量大脑活动。我们的中心假设是，收集高采样 个体数据将使我们能够检测大脑活动的模式，这些模式可以在个体身上可靠地复制。 水平，并预测行为和临床症状。大量的fMRI和fNIRS数据已经证明 (a)在执行功能任务期间，ADHD患者的前额叶回路中的一致性低激活，以及（B） 注意缺陷多动障碍患者前额叶回路活动减退与行为和临床症状之间的关系。我们 将收集30名ADHD儿童和30名典型儿童的前额叶活动的高采样fNIRS数据。 发展控制。将在受试者休息和/或进行活动时，在三周内每天收集数据 智能手机上的认知任务。我们的跨学科，多机构团队已经开发了一个非常 低成本（<100美元）的原型可穿戴，无线fNIRS系统，用于监测前额叶皮层的活动， 我们会透过这项建议，改善（目标1）和落实（目标2）。目标1：优化可穿戴设备原型， 无线、多通道、智能手机操作的光学成像系统，用于定期监测前额叶 活动在家里。目的2：测试和验证所提出的系统，以可靠地监测前额叶活动， ADHD儿童成功完成这项首创的研究将有助于改变目前的模式 从实验室，少量的神经成像，并为开发有效的生物标志物， 临床上用于精神障碍的诊断和早期检测，监测治疗反应。

项目成果

Decoding the heterogeneity of Alzheimer's disease diagnosis and progression using multilayer networks.

• DOI: 10.1038/s41380-022-01886-z
• 发表时间: 2023-06
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Avelar-Pereira, Barbara;Belloy, Michael E.;O'Hara, Ruth;Hosseini, S. M. Hadi
• 通讯作者: Hosseini, S. M. Hadi

Functional near-infrared spectroscopy in developmental psychiatry: a review of attention deficit hyperactivity disorder.

• DOI: 10.1007/s00406-021-01288-2
• 发表时间: 2022-03
• 期刊: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
• 影响因子: 4.7
• 作者: Gosse, Louisa K.;Bell, Sarah W.;Hosseini, S. M. Hadi
• 通讯作者: Hosseini, S. M. Hadi

The Effect of Baseline Performance and Age on Cognitive Training Improvements in Older Adults: A Qualitative Review.

• DOI: 10.14283/jpad.2020.55
• 发表时间: 2021
• 期刊: The journal of prevention of Alzheimer's disease
• 作者: Shaw JS;Hosseini SMH
• 通讯作者: Hosseini SMH

A low-cost, wearable, do-it-yourself functional near-infrared spectroscopy (DIY-fNIRS) headband.

低成本、可穿戴、DIY 功能性近红外光谱 (DIY-fNIRS) 头带。

• DOI: 10.1016/j.ohx.2021.e00204
• 发表时间: 2021
• 期刊: HardwareX
• 影响因子: 2.2
• 作者: Tsow,Francis;Kumar,Anupam;Hosseini,SmHadi;Bowden,Audrey
• 通讯作者: Bowden,Audrey

Quantitative measurement of macromolecular tissue properties in white and gray matter in healthy aging and amnestic MCI.

• DOI: 10.1016/j.neuroimage.2021.118161
• 发表时间: 2021-08-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Gozdas E;Fingerhut H;Wu H;Bruno JL;Dacorro L;Jo B;O'Hara R;Reiss AL;Hosseini SMH
• 通讯作者: Hosseini SMH