New and improved treatment strategies for neonatal seizures

新生儿癫痫发作的新的和改进的治疗策略

• 批准号: nhmrc : 1144414
• 负责人: A/Pr Michael Fahey
• 金额: $ 59.72万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-improved-treatment-neonatal-seizures/1320187
• 关键词: New; improved; treatment; strategies; neonatal

Around 10% of neonates in Australia are diagnosed with seizures each year. Seizures worsen neurodevelopmental outcome following hypoxic brain injury. Despite evidence of the limited effectiveness and potential neurotoxicity of current anti-seizure medication, treatment has not changed for many decades. The objective of this study is to optimise treatment of neonatal seizures with a compound that is effective and does not cause harm, or indeed provides neuroprotection for the compromised brain.

澳大利亚每年约有10%的新生儿被诊断为癫痫发作。癫痫发作会恶化缺氧性脑损伤后的神经发育结果。尽管有证据表明目前的抗癫痫药物的有效性和潜在的神经毒性是有限的，但治疗几十年来没有改变。这项研究的目的是用一种有效的、不会造成伤害的化合物来优化新生儿癫痫的治疗，或者确实为受损的大脑提供神经保护。