Enhancing the neuroprotective benefit of hypothermia with melatonin in the asphyxiated neonate

褪黑素增强低温对窒息新生儿的神经保护作用

• 批准号: nhmrc : 1048039
• 负责人: A/Pr Michael Fahey
• 金额: $ 52.37万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/enhancing-neuroprotective-benefit-asphyxiated-neonate/111993
• 关键词: Enhancing; neuroprotective; benefit; hypothermia; melatonin

During labour, asphyxic episodes which cause a severe reduction in oxygen supply can become prolonged and result in perinatal brain injury, termed Hypoxic Ischemic Encephalopathy, which may underlie cerebral palsy. Presently, newborn infants with suspected encephalopathy are cooled, which modestly protects the brain against cellular injury. We propose that the administration of melatonin to the newborn, in addition to cooling, will decrease the post-asphyxic formation of oxygen free radicals, thereby reducing the progression of brain damage.

在分娩过程中，窒息发作导致氧气供应严重减少，可能会延长并导致围产期脑损伤，称为缺氧缺血性脑病，这可能是脑瘫的基础。目前，疑似脑病的新生儿被冷却，这适度地保护大脑免受细胞损伤。我们建议，褪黑激素的新生儿，除了冷却，将减少窒息后形成的氧自由基，从而减少脑损伤的进展。