PREDICTIVE MODELING OF BIOELECTRIC ACTIVITY ON MAMMALIAN MULTILAYERED NEURONAL STRUCTURES IN THE PRESENCE OF SUPRAPHYSIOLOGICAL ELECTRIC FIELDS
超生理电场存在下哺乳动物多层神经元结构生物电活动的预测建模
基本信息
- 批准号:10015260
- 负责人:
- 金额:$ 66.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-15 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAffectAlzheimer&aposs DiseaseAxonBiologicalCaliforniaCommunitiesComputer SimulationCouplingDataDevelopmentDisabled PersonsDiseaseElectric StimulationElectrodesElectrophysiology (science)EngineeringEpilepsyEpisodic memoryExtracellular SpaceFamilyFoundationsFutureGoalsGrantHippocampus (Brain)KineticsLinkMagnetismMedical DeviceMemoryMethodologyMethodsModelingMolecularMonitorNervous system structureNeurodegenerative DisordersNeurogliaNeurologicNeuronsNeurosciencesOutcomeOutputPathogenicityPatternPerformancePopulationPositioning AttributePropertyProsthesisPublic HealthResearchRetinaSourceSpatial DistributionStructureSynapsesSystemTechniquesTestingTimeTissuesTraining ActivityUnited States National Institutes of HealthUniversitiesUtahWorkbasebioelectricitycognitive functioncrosslinkdensitydesignelectric fieldextracellularimprovedinsightmodels and simulationmolecular modelingmulti-electrode arraysmulti-scale modelingneural prosthesisneuropathologynext generationnovelpredictive modelingreceptorrelating to nervous systemsimulationspatiotemporaltool
项目摘要
Project Abstract
The end goal of this multiscale modeling research is to bridge the gap existing between three-dimensional, full-
wave, macro-modeling of electrical and magnetic biointeractions (global modeling) and cellular-level modeling
strategies. Our research team is composed of engineers and neuroscientists that are experts in all
computational and experimental aspects necessary to fill the existing gaps in multi-scale modeling.
This multi-university effort to predict spatio-temporal distributions of active neurons based on current densities
created by multi-electrode electrical stimulation depends on having a set of "core models" of molecular
(receptor-channel kinetics), synaptic, neuron, and multi-neuron activity. These models and their inputs and
outputs must be integrated into a global model of the extracellular media/matrix including relevant multi-
electrode arrays. Successful modeling at these levels will allow hypotheses about space-time patterns of
electrical stimulation to produce predictions about the number and distribution of activated inputs (based on
known spatial distributions of afferent axons). The linked molecular, synaptic, neuron, multi-neuron, and global
model will provide the basis for emerging predictions of the spatio-temporal distribution of active neurons and
thus, the spatio-temporal distributions of spike train activity that encode all information in the nervous system.
Further, we believe the proposed multiscale modeling framework constitutes an ideal platform capable of
generating novel insights into the pathogenic mechanisms precipitating abnormal hippocampal function.
Although the proposed research is focused on the hippocampal system, our effort will capitalize on our
multiscale modeling accomplishments during the performance period of our original multiscale modeling U01
grant, in the realm of both retinal and cortical prostheses.
项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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THEODORE W. BERGER其他文献
THEODORE W. BERGER的其他文献
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{{ truncateString('THEODORE W. BERGER', 18)}}的其他基金
Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
哺乳动物多层神经元生物电活动的预测模型
- 批准号:
8339860 - 财政年份:2012
- 资助金额:
$ 66.89万 - 项目类别:
PREDICTIVE MODELING OF BIOELECTRIC ACTIVITY ON MAMMALIAN MULTILAYERED NEURONAL STRUCTURES IN THE PRESENCE OF SUPRAPHYSIOLOGICAL ELECTRIC FIELDS
超生理电场存在下哺乳动物多层神经元结构生物电活动的预测建模
- 批准号:
10242065 - 财政年份:2012
- 资助金额:
$ 66.89万 - 项目类别:
Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
哺乳动物多层神经元生物电活动的预测模型
- 批准号:
8731951 - 财政年份:2012
- 资助金额:
$ 66.89万 - 项目类别:
Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
哺乳动物多层神经元生物电活动的预测模型
- 批准号:
8918687 - 财政年份:2012
- 资助金额:
$ 66.89万 - 项目类别:
PREDICTIVE MODELING OF BIOELECTRIC ACTIVITY ON MAMMALIAN MULTILAYERED NEURONAL STRUCTURES IN THE PRESENCE OF SUPRAPHYSIOLOGICAL ELECTRIC FIELDS
超生理电场存在下哺乳动物多层神经元结构生物电活动的预测建模
- 批准号:
9493148 - 财政年份:2012
- 资助金额:
$ 66.89万 - 项目类别:
Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
哺乳动物多层神经元生物电活动的预测模型
- 批准号:
8545197 - 财政年份:2012
- 资助金额:
$ 66.89万 - 项目类别:
Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
哺乳动物多层神经元生物电活动的预测模型
- 批准号:
9120372 - 财政年份:2012
- 资助金额:
$ 66.89万 - 项目类别:
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