Michigan Nutrition Obesity Research Center

摘要/总结-总体MNORC 密歇根营养肥胖研究中心（MNORC）最初于2010年获得资助， 支持，整合和加强与肥胖和营养的教师之间的研究 密歇根大学MNORC的目标是创造一个鼓励和 使来自临床前、临床和转化研究学科的研究人员能够整合 先进的表型分析和数据分析工具，以更全面地定义个体和群体 这些特征是由膳食营养成分或量引起的。 这将通过提供核心实验室基础设施、教育和培训 机会和试点赠款，以提高研究生产力。MNORC扩大了 研究基础设施和核心产品，以满足研究界的需求 并支持整个UM校园的营养和肥胖研究的扩展。这 机构投资强调了这一点， 提议MNORC拥有102名成员，他们是UM各个学校的教师。这些 教师目前控制着每年不到2600万美元的营养/肥胖相关资金的直接成本 R奖和非NIH来源的资金，以及每年额外的3000万美元， 营养/肥胖相关的F、K、P、T和U赠款。MNORC核心包括行政 核心，将监督和整合的研究，临床和教育职能， 中心，包括年度研讨会，研讨会系列，培训大学生，营养师， 医学院学生，内务部工作人员和研究员在营养和肥胖护理的广度， 研究;营养，运动和表型测试核心，这将提供专业知识 和基础设施，用于对住院患者进行复杂的代谢和神经行为测试 和门诊设置;分子表型核心，将继续支持 目标和非目标代谢组学分析以及多组学数据的新举措 整合;新成立的脂肪组织核心将提供专业知识和技术 服务于基础和临床生物医学研究人员有兴趣调查脂肪细胞如何 在整个身体的发展，功能，并与其他类型的细胞相互作用;儿童 肥胖研究中心将支持专注于转化研究的研究人员， 儿童超重/肥胖，利用学习卫生系统和卫生信息 技术在密歇根大学。MNORC将继续支持权重 管理计划，将研究整合到一个非常成功的成人临床减肥 该方案目前正在扩大到儿童、家庭和寻求怀孕的妇女。 许多研究人员通过该计划访问患者，生物样本和收集的数据 为了他们自己的研究。在下一个资助期内，MNORC将继续与 与研究基地一起确定新的支持领域并调整服务产品 符合社区的需要。

Abstract/Summary – Overall MNORC The Michigan Nutrition Obesity Research Center (MNORC) was initially funded in 2010 to support, integrate and enhance research related to obesity and nutrition among the faculty of the University of Michigan. The goal of MNORC is to create an environment to encourage and enable researchers from preclinical, clinical and translational research disciplines to integrate advanced, phenotyping and data analytic tools to more fully define individual and population characteristics that arise in response to dietary nutrient composition or amount. This will be accomplished by providing core laboratory infrastructure, educational and training opportunities and pilot grants to enhance research productivity. The MNORC has expanded the research infrastructure and Core offerings in response to the needs of the research community and has supported the expansion of nutrition and obesity research across the UM campus. This is highlighted by the institutional investment to establish two new cores that are part of this proposal. MNORC has 102 members that are faculty across the various schools at UM. These faculty currently control just under $26M/year of direct costs in nutrition/obesity-related funding for R-awards and funding from non-NIH sources and an additional $30M/year in nutrition/obesity-related F, K, P, T and U grants. The MNORC Cores include the Administrative Core, which will oversee and integrate the research, clinical and education functions of the Center, including an annual symposium, seminar series, training for undergraduates, dieticians, medical students, house staff and fellows in the breadth of nutrition and obesity care and research; the Nutrition, Exercise and phenotype Testing Core, which will provide expertise and infrastructure for sophisticated metabolic and neurobehavioral testing of humans in inpatient and outpatient settings; the Molecular Phenotyping Core, which will continue supporting targeted and untargeted metabolomics profiling as well as new initiatives for multi-omics data integration; the newly established Adipose Tissue Core will provide expertise and technical services to basic and clinical biomedical researchers interested in investigating how adipocytes throughout the body develop, function, and interact with other cell types; the Childhood Obesity Research Core will support investigators focused on translational research in childhood overweight/obesity by leveraging learning health systems and health information technology at the University of Michigan. MNORC will continue to support the Weight Management Program which integrates research into a highly successful adult clinical weight loss program and is now being extended into children, families and women seeking to become pregnant. Numerous investigators access the patients, biosamples and data collected through this program for their own research. Through the next funding period, MNORC will continue to communicate with the research base to identify new areas for support and adjust the service offerings consistent with the needs of the community.