Building Capacity to Address the Burden of Cardiometabolic Risk Factors and Diseases in LMICs

摘要 流行病学从传染病向非传染性疾病的转变导致艾滋病毒/艾滋病发病率急剧上升， 死亡率和残疾率的下降。这在一定程度上归因于重要的变化 在生活方式和饮食方面，这被描述为流行病学的转变。心脏代谢危险因素， 增加CVD的风险并促进CVD的发作，包括代谢功能障碍的组合 主要特征为高血压、胰岛素抵抗、葡萄糖耐量受损、血脂异常，以及 中枢性肥胖这场危机促使人们呼吁对研究进行战略投资，包括区域性研究。 发展，跨国家联网，扩大跨部门合作伙伴关系，以改善翻译， 低收入和中等收入国家（LMIC）的创新和患者护理。在此D43培训应用程序中， 福格蒂国际中心，华盛顿大学（UW）全球卫生系将合作 与尼泊尔和肯尼亚的两个长期合作伙伴合作，解决心脏代谢疾病和风险因素 通过严格的教育计划，强大的导师和相关的研究经验。这 合作汇集了加德满都大学（KU），具有解决CVD的新兴能力 作为国家优先事项，内罗毕大学（UON）成功地实施了多项 国际培训方案，为增强下一代的能力提供协同办法 在这些资源匮乏的环境中解决非传染性疾病问题。该方案的具体目标是：1） 通过在以下领域建立研究能力，增加对心脏代谢疾病和风险因素的高影响研究： 加德满都大学（KU）和内罗毕大学（UN）通过硕士学位水平培养，包括6名 临床研究人员，来自尼泊尔和肯尼亚各3人，学习并获得UW MPH学位; 2）支持 培训6名学生完成KU公共卫生硕士学位，课程由D43教师提供; 在肯尼亚和尼泊尔提供中期和短期培训，重点是基本研究和领导能力 技能，包括一个为期一年的证书课程，使用在线远程学习，最终导致项目， 和UW，KU和UON核心教师提供的国内研讨会。会议汇集了 将向KU和UON研究人员以及县卫生主任提供NCD社区成员， 在这两个中低收入国家促进社区参与当地护理、治疗和预防工作。使用UW的井- 该计划将建立急需的实施科学研究， 这将有助于提高昆明大学和安大略大学的能力，并有助于改变中低收入国家非传染性疾病流行的面貌。

ABSTRACT An epidemiological shift from infectious to non-communicable diseases (NCDs) has led to a dramatic increase in mortality and disability over the past several decades. This has been attributed in part to important changes in lifestyles and diets, which have been described as the epidemiologic transition. Cardiometabolic risk factors, which increase the risk of and promote onset of CVD, include a combination of metabolic dysfunctions primarily characterized by hypertension, insulin resistance, impaired glucose tolerance, dyslipidemia, and central adiposity. This crisis has led to a call for strategic investment in research including regional development, networking across countries, and expanding cross-sectoral partnerships to improve translation, innovation and patient care in low- and middle-income countries (LMICs). In this D43 Training Application to Fogarty International Center, the University of Washington (UW) Department of Global Health will collaborate with two long-standing partners in Nepal and Kenya to address cardiometabolic diseases and risk factors through rigorous educational programs, strong mentorship and relevant research experiences. This collaboration brings together Kathmandu University (KU), with an emerging capacity to address CVD as a national priority, and University of Nairobi (UON), which has successfully implemented multiple international training programs, to provide a synergistic approach for empowering the next generation of researchers to address NCDs in these low resource settings. Specific aims of this program are: 1) Increase high-impact research on cardiometabolic disease and risk factors by building research capacity at Kathmandu University (KU) and University of Nairobi (UN) through Master's level degree training to include 6 clinician-researchers, 3 each from Nepal and Kenya, to study and receive UW MPH degrees; 2) Support the training of 6 students to complete an MS degree in Public Heath from KU with courses offered by D43 faculty; and 3) Provide mid- and short-term training in Kenya and Nepal focusing on essential research and leadership skills including a one-year certificate program using on-line distance learning resulting in culminating projects, and in-country workshops offered by UW, KU and UON Core faculty. Conferences that bring together members of the NCD community with KU and UON researchers and county health directors will be offered to promote community engagement in local care, treatment and prevention in both LMICs. Using UW's well- established approaches to training, this program will establish greatly needed implementation science research capacity at KU and UON and contribute to changing the face of the NCD epidemic in LMICs.