Building Capacity to Address the Burden of Cardiometabolic Risk Factors and Diseases in LMICs

摘要 从传染病到非传染性疾病(NCDs)的流行病学转变导致病例急剧增加 在过去的几十年里，死亡率和伤残率都有所下降。这在一定程度上归因于重要的变化 在生活方式和饮食方面，这被描述为流行病学的转变。心脏代谢危险因素， 增加心血管疾病的风险并促进其发病，包括代谢功能障碍的组合 主要表现为高血压、胰岛素抵抗、糖耐量受损、血脂异常和 中心性肥胖症。这场危机导致了对包括区域研究在内的研究进行战略投资的呼吁。 发展，跨国联网，以及扩大跨部门伙伴关系以改进翻译， 低收入和中等收入国家的创新和病人护理。在此D43培训应用程序中 华盛顿大学(UW)全球卫生系Fogarty国际中心将合作 与尼泊尔和肯尼亚的两个长期合作伙伴共同应对心脏代谢性疾病和风险因素 通过严格的教育计划，强大的导师和相关的研究经验。这 协作将加德满都大学(KU)与解决心血管疾病的新兴能力结合在一起 作为国家优先事项，内罗毕大学(UON)成功地实施了多项 国际培训方案，为增强下一代能力提供协同方法 在这些资源匮乏的情况下解决非传染性疾病的研究人员。本计划的具体目标是：1) 通过建设研究能力，增加对心脏代谢性疾病和风险因素的高影响力研究 加德满都大学(KU)和内罗毕大学(UN)通过硕士学位培训包括6 临床医生-研究人员，来自尼泊尔和肯尼亚各3人，学习和获得密歇根大学公共卫生硕士学位；2)支持 培训6名学生完成KU公共卫生硕士学位，课程由D43教员提供； 3)在肯尼亚和尼泊尔提供中短期培训，重点是基本研究和领导力 技能包括一个为期一年的证书计划，使用在线远程学习，最终导致项目， 以及由威斯康星大学、昆士兰大学和UON核心教职员工提供的国内研讨会。汇聚在一起的会议 KU和UON研究人员以及县卫生主任的NCD社区成员将被提供给 促进社区参与两个小岛屿发展中国家的当地护理、治疗和预防工作。使用威斯康星大学的油井- 建立了培训的方法，该计划将建立非常需要的实施科学研究 KU和UON的能力，并有助于改变LMIC中非传染性疾病流行的面貌。

ABSTRACT An epidemiological shift from infectious to non-communicable diseases (NCDs) has led to a dramatic increase in mortality and disability over the past several decades. This has been attributed in part to important changes in lifestyles and diets, which have been described as the epidemiologic transition. Cardiometabolic risk factors, which increase the risk of and promote onset of CVD, include a combination of metabolic dysfunctions primarily characterized by hypertension, insulin resistance, impaired glucose tolerance, dyslipidemia, and central adiposity. This crisis has led to a call for strategic investment in research including regional development, networking across countries, and expanding cross-sectoral partnerships to improve translation, innovation and patient care in low- and middle-income countries (LMICs). In this D43 Training Application to Fogarty International Center, the University of Washington (UW) Department of Global Health will collaborate with two long-standing partners in Nepal and Kenya to address cardiometabolic diseases and risk factors through rigorous educational programs, strong mentorship and relevant research experiences. This collaboration brings together Kathmandu University (KU), with an emerging capacity to address CVD as a national priority, and University of Nairobi (UON), which has successfully implemented multiple international training programs, to provide a synergistic approach for empowering the next generation of researchers to address NCDs in these low resource settings. Specific aims of this program are: 1) Increase high-impact research on cardiometabolic disease and risk factors by building research capacity at Kathmandu University (KU) and University of Nairobi (UN) through Master's level degree training to include 6 clinician-researchers, 3 each from Nepal and Kenya, to study and receive UW MPH degrees; 2) Support the training of 6 students to complete an MS degree in Public Heath from KU with courses offered by D43 faculty; and 3) Provide mid- and short-term training in Kenya and Nepal focusing on essential research and leadership skills including a one-year certificate program using on-line distance learning resulting in culminating projects, and in-country workshops offered by UW, KU and UON Core faculty. Conferences that bring together members of the NCD community with KU and UON researchers and county health directors will be offered to promote community engagement in local care, treatment and prevention in both LMICs. Using UW's well- established approaches to training, this program will establish greatly needed implementation science research capacity at KU and UON and contribute to changing the face of the NCD epidemic in LMICs.