Neurologic manifestations of cerebrovascular disease in Da Nang, Viet Nam

描述（由申请人提供）：神经和精神疾病是重要的和日益增长的发病和死亡原因，影响全世界多达10亿人，造成近700万人死亡。世卫组织最近估计，就总残疾调整生命年（DALYs）而言，神经系统疾病是全球最高的疾病负担。其中最严重的疾病包括脑血管病、阿尔茨海默病和其他痴呆症，预计到2030年将占DALYs的最高百分比。越南等发展中国家目前正在经历从传染病向慢性病的健康过渡，这些疾病对人口健康的影响将特别具有破坏性。为了满足增加越南评估神经系统疾病的基础设施和研究能力的需要，我们建议在越南岘港卫生部下属的医生之间开展合作；岘港精神病医院；岘港医院心脏病科和放射科；以及华盛顿大学流行病学和神经病学系，以实现以下目标：(1)通过正式和非正式会议、神经学家和卫生官员的投入以及该地区已完成/正在进行的研究清单，评估开展全面研究的研究和培训需求，重点是评估岘港的神经疾病；(2)通过召集当地卫生专家指导委员会来开展合作，指导项目，并提供合作研究者之间的国际旅行交流；(3)实施一项试点研究，以评估岘港脑血管疾病的患病率，并评估400户居民的身体和认知功能；(4)将能力建设和培训纳入合作，促进卫生部对人类受试者的审查，提供研究方法/神经流行病学的教学课程，并建立一个计算机研究实验室，供希望主要在神经科学领域开展研究的研究人员使用。试点研究将纳入从该省现有的经点算名单中随机选择的家庭。护士访谈小组将管理筛选问卷，以评估中风和认知功能障碍。将计算疾病的流行率。该项目将改善岘港未来神经学研究的基础设施，以制定一项（或多项）中风和/或痴呆症的合作后续R01资助提案。公共卫生相关性：该项目的意义在于，通过评估当前的当地研究能力、提供必要的培训和设备、制定IRB、加强与越南调查人员的合作以及收集有关脑血管疾病的初步数据，发展在越南岘港开展神经系统疾病未来研究的能力。

DESCRIPTION (provided by applicant): Neurologic and psychiatric disorders are important and growing causes of morbidity and mortality affecting up to 1 billion people and causing almost 7 million deaths world-wide. The WHO recently estimated that neurological disorders represent the highest global burden of disease in terms of total disability-adjusted life-years (DALYs). The most critical of these, projected to account for the highest percentage of DALYs in 2030, include cerebrovascular disease, Alzheimer's disease and other dementias. Developing countries such as Viet Nam are currently experiencing a health transition from infectious to chronic diseases in which the impact on the health of the population from these diseases will be especially devastating. In order to address the need to increase infrastructure and research capacity for assessing neurologic diseases in Viet Nam, we propose to develop a collaboration between physicians affiliated with the Department of Health in Da Nang, Viet Nam; the Da Nang Psychiatric Hospital; the Cardiology and Radiology Departments at the Da Nang Hospital; and the University of Washington Departments of Epidemiology and Neurology to meet the following objectives: (1) assess the research and training needs to conduct comprehensive studies focused on evaluation of neurologic diseases in Da Nang through formal and informal meetings, input of neurologists and health officers, and an inventory of research completed/underway in the region; (2) develop collaborations through convening a Steering Committee of local health experts to guide the project, and provide international travel exchanges between co-investigators; (3) implement a pilot research study to assess the prevalence of cerebrovascular disease in Da Nang and to evaluate physical and cognitive function in adults residing in 400 households; and (4) integrate capacity building and training into the collaboration by facilitating human subjects review in the Department of Health, providing instructional courses in research methods/neuroepidemiology, and developing a computer research lab for use by investigators wishing to implement studies primarily in the neurologic sciences. The pilot study will access households randomly selected from enumerated lists available for the province. Teams of nurse interviewers will administer screening questionnaires to assess stroke and cognitive dysfunction. Prevalence rates of disease will be calculated. This project will result in improving infrastructure for future research on neurologic topics in Da Nang for development of one (or more) collaborative follow-up R01 grant proposals in stroke and/or dementia. PUBLIC HEALTH RELEVANCE: The significance of this project is to develop capacity to conduct future research in neurologic diseases in Da Nang, Viet Nam, by assessing current local research capacity, providing the necessary training and equipment, developing an IRB, strengthening collaborations with Vietnamese investigators, and collecting preliminary data on cerebrovascular disease.