Neurologic manifestations of cerebrovascular disease in Da Nang, Viet Nam

描述(申请人提供)：神经和精神障碍是发病率和死亡率的重要和日益增长的原因，影响多达10亿人，并在世界范围内造成近700万人死亡。世界卫生组织最近估计，就总伤残调整寿命年(DALY)而言，神经疾病是全球疾病负担最高的。其中最严重的疾病包括脑血管疾病、阿尔茨海默病和其他痴呆症，预计将在2030年占DALY的最高比例。越南等发展中国家目前正在经历从传染病到慢性病的健康过渡，这些疾病对人民健康的影响将特别严重。为了满足增加越南评估神经系统疾病的基础设施和研究能力的需要，我们提议在越南岘港卫生局附属医生、岘港精神病院、岘港医院心内科和放射科以及华盛顿大学流行病学和神经病学系之间开展合作，以实现以下目标：(1)通过正式和非正式会议、神经学家和卫生官员的投入以及该区域已完成/正在进行的研究的清单，评估研究和培训需求，以开展以评估岘港神经疾病为重点的综合研究；(2)通过召集一个由当地健康专家组成的指导委员会来指导该项目，并提供协查人员之间的国际旅行交流，发展合作；(3)实施一项试验性研究研究，以评估岘港脑血管疾病的患病率，并评估居住在400个家庭的成年人的身体和认知功能；及(4)将能力建设和培训融入到合作中，方法是促进卫生署的人体研究，提供研究方法/神经流行病学的教学课程，并开发一个计算机研究实验室，供希望主要进行神经科学研究的研究人员使用。试点研究将访问从该省现有的列举名单中随机挑选的家庭。护士面试官团队将对筛查问卷进行管理，以评估中风和认知功能障碍。将计算疾病的患病率。该项目将为岘港未来神经学主题的研究改善基础设施，以制定一个(或多个)中风和/或痴呆症的R01协作性后续拨款建议。与公共卫生相关：该项目的意义在于通过评估当前的当地研究能力、提供必要的培训和设备、发展IRB、加强与越南研究人员的合作以及收集脑血管疾病的初步数据，发展未来在越南岘港进行神经疾病研究的能力。

DESCRIPTION (provided by applicant): Neurologic and psychiatric disorders are important and growing causes of morbidity and mortality affecting up to 1 billion people and causing almost 7 million deaths world-wide. The WHO recently estimated that neurological disorders represent the highest global burden of disease in terms of total disability-adjusted life-years (DALYs). The most critical of these, projected to account for the highest percentage of DALYs in 2030, include cerebrovascular disease, Alzheimer's disease and other dementias. Developing countries such as Viet Nam are currently experiencing a health transition from infectious to chronic diseases in which the impact on the health of the population from these diseases will be especially devastating. In order to address the need to increase infrastructure and research capacity for assessing neurologic diseases in Viet Nam, we propose to develop a collaboration between physicians affiliated with the Department of Health in Da Nang, Viet Nam; the Da Nang Psychiatric Hospital; the Cardiology and Radiology Departments at the Da Nang Hospital; and the University of Washington Departments of Epidemiology and Neurology to meet the following objectives: (1) assess the research and training needs to conduct comprehensive studies focused on evaluation of neurologic diseases in Da Nang through formal and informal meetings, input of neurologists and health officers, and an inventory of research completed/underway in the region; (2) develop collaborations through convening a Steering Committee of local health experts to guide the project, and provide international travel exchanges between co-investigators; (3) implement a pilot research study to assess the prevalence of cerebrovascular disease in Da Nang and to evaluate physical and cognitive function in adults residing in 400 households; and (4) integrate capacity building and training into the collaboration by facilitating human subjects review in the Department of Health, providing instructional courses in research methods/neuroepidemiology, and developing a computer research lab for use by investigators wishing to implement studies primarily in the neurologic sciences. The pilot study will access households randomly selected from enumerated lists available for the province. Teams of nurse interviewers will administer screening questionnaires to assess stroke and cognitive dysfunction. Prevalence rates of disease will be calculated. This project will result in improving infrastructure for future research on neurologic topics in Da Nang for development of one (or more) collaborative follow-up R01 grant proposals in stroke and/or dementia. PUBLIC HEALTH RELEVANCE: The significance of this project is to develop capacity to conduct future research in neurologic diseases in Da Nang, Viet Nam, by assessing current local research capacity, providing the necessary training and equipment, developing an IRB, strengthening collaborations with Vietnamese investigators, and collecting preliminary data on cerebrovascular disease.