Restrictive and binge eating during adolescence: the role of negative self-related cognitions and social stress

青春期的限制性饮食和暴饮暴食：消极的自我相关认知和社会压力的作用

• 批准号: 10054282
• 负责人: Lisa Ranzenhofer
• 金额: $ 19.6万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10054282
• 关键词: 17 year old; Acute; Address; Adolescence; Adolescent; Affect; Anorexia Nervosa; Attention; Award; Behavior Disorders; Behavioral; Binge Eating; Binge eating disorder; Bulimia; Categories; Cellular Phone; Chronic; Clinical Research; Cognition; Communication; Data; Development; Diagnosis; Disease susceptibility; Eating; Eating Disorders; Ecological momentary assessment; Electroencephalography; Emotional; Environment; Etiology; Evaluation; Event-Related Potentials; Exhibits; Female Adolescents; Frequencies; Impairment; Intervention; K-Series Research Career Programs; Knowledge; Language; Life; Link; Maintenance; Measures; Medical; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Modeling; Monitor; Morbidity - disease rate; Neurobiology; Participant; Patient Self-Report; Patients; Pattern; Phase; Phenotype; Positioning Attribute; Process; Quality of life; Reaction Time; Recurrence; Research; Research Personnel; Research Training; Risk; Risk Factors; Role; Social Functioning; Social Interaction; Social Network; Social Problems; Social Processes; Stress; Structure; Technology; Testing; Text Messaging; Time; Training; Woman; aged; biobehavior; biopsychosocial; child depression; design; digital; emotional stimulus; girls; improved; neurophysiology; patient oriented; peer; psychosocial; relating to nervous system; restrictive eating; self esteem; social media; social stress; stress disorder; stressor

This Mentored Patient-Oriented Research Career Development Award is focused on elucidating neural and psychosocial mechanisms of eating disorders in adolescence. The research and training plans are designed to prepare the investigator to conducted independent research in adolescent eating disorders through training in biobehavioral and psychosocial mechanisms and sophisticated methods for their assessment. Eating disorders are characterized by high rates of physical and psychiatric morbidity, and adolescence is a developmental phase in which eating disorders commonly emerge. Negative self-related schema (i.e., low self-esteem) and poor social functioning are hypothesized to contribute to the onset and/or maintenance of eating disorders by promoting maladaptive restrictive eating and recurrent binge eating. However, few studies have investigated these constructs outside the self-report domain, and examinations of direct associations with eating disorder behavior are limited. Thus, the role of self-related schema and poor social functioning as eating disorder etiologic and maintenance factors, as well as their utility as treatment targets, remain key empirical gaps. This K23 aims to address these gaps by testing associations among negative self-related schema, social functioning, and eating disorder behavior across units of analysis including neurophysiological activity, phenotypes, and real-time passive monitoring. Participants will include female adolescents aged 14-17 years with maladaptive restrictive eating (defined by a diagnosis of AN, n = 30), recurrent binge eating (defined as a diagnosis of bulimia nervosa (BN) or binge eating disorder (BED), n = 30), and healthy controls (n = 30). At baseline, adolescents will complete a self-referential encoding task while electroencephalography data are acquired to probe behavioral and neurophysiological processes of self-related schema. To probe real-time social processes, we will leverage smartphone technology and use a passive sensing application over a 6- month period to continuously measure key aspects of social functioning—size of social network, frequency of interactions, and negative content of interactions. Adolescents in the eating disorder groups will complete ecological momentary assessment 1 week/month for six-months to assess the frequency and intensity of maladaptive restrictive and binge eating in the natural environment. The following aims will be addressed: First, we will compare self-related schema and social functioning between adolescents with an eating disorder and healthy controls (Aim 1). Second, we will test the associations between self-related schema and social functioning with the frequency and intensity of eating disorder behavior over 6-months (Aim 2). Last, we will test the interaction between negative self-related schema and social functioning to predict eating disorder behavior. The current project will elucidate whether self-related schema and social functioning distinguish adolescents with an eating disorder and are associated with eating disorder behavior. These findings will inform the utility of these hypothesized mechanisms as treatment targets for adolescents with eating disorders.

这个指导以病人为导向的研究职业发展奖的重点是阐明神经和 青少年饮食失调的心理社会机制。研究和培训计划旨在 通过以下培训，使研究者能够对青少年进食障碍进行独立研究： 生物行为和心理社会机制及其评估的复杂方法。饮食失调 的特点是身体和精神疾病的发病率高，青春期是一个发展阶段， 在这个阶段，饮食失调通常会出现。消极的自我相关图式（即，低自尊）和 社会功能不佳被假设为导致进食障碍的发生和/或维持， 促进适应不良的限制性饮食和反复暴食。然而，很少有研究调查 自我报告领域之外的这些结构，以及与进食障碍直接相关的检查， 行为是有限的。因此，自我相关的图式和不良的社会功能作为饮食失调的作用 病因和维持因素，以及它们作为治疗靶点的效用，仍然是关键的经验空白。这 K23旨在通过测试消极的自我相关图式、社会性和自我认知之间的关联来解决这些差距。 功能和饮食失调行为，包括神经生理活动， 表型和实时被动监测。参与者将包括14-17岁的女性青少年 适应不良的限制性饮食（由AN的诊断定义，n = 30），反复暴食（定义为 诊断为神经性贪食症（BN）或暴食症（BED），n = 30）和健康对照（n = 30）。在 基线，青少年将完成自我参照编码任务，而脑电图数据是 习得的，以探讨自我相关图式的行为和神经生理过程。实时探测 社会进程，我们将利用智能手机技术，并使用被动传感应用程序超过6- 一个月的时间来持续衡量社会功能的关键方面-社会网络的规模， 互动和互动的负面内容。饮食失调组的青少年将完成 生态瞬时评估，为期六个月，每月一周，以评估 适应不良的限制和暴饮暴食的自然环境。将致力于实现以下目标：第一， 我们将比较青少年饮食失调和 健康对照组（目标1）。其次，我们将检验自我相关图式与社会认知图式之间的关系， 6个月内进食障碍行为的频率和强度（目标2）。最后，我们将 检验消极自我相关图式与社会功能之间的交互作用，以预测进食障碍 行为当前的项目将阐明自我相关图式和社会功能是否存在区别 青少年饮食失调，并与饮食失调行为有关。这些发现将 告知这些假设的机制作为青少年饮食失调的治疗目标的效用。