Ambient Air Pollution, Stress, Oxidative Markers and Respiratory Health in Mexican Children

项目摘要 我是一名环境流行病学家，主要研究方向是发育窗口的作用， 多重暴露的联合影响和产前/生命早期暴露于 化学和非化学应激源影响儿童肺发育。本提案的目的是 通过将环境空气污染与环境污染之间的联系， 对肺发育的压力，并确定这些暴露的早期生物效应的生物标志物。 正式的课程和博士的专家指导。罗莎琳德赖特，安德烈巴卡雷利，罗伯特赖特， Maria Martha Tellez-Rojo、布伦特Coull、Alfin Vicencio和Allan Just将使我能够获得 成为一名独立的跨学科研究人员所需的技能。这次训练会让我 实现我的长期职业目标：率先在正在进行的墨西哥城研究呼吸健康 为了研究这些和其他环境暴露， 机制，以及随后对肺功能和哮喘风险的纵向影响， 成熟点吧所有相关暴露和协变量数据均存在于现有的良好表型妊娠队列中 [肥胖、生长、环境和社会压力源规划研究（PROGRESS）研究利用 本文所我将在队列中添加呼吸表型。具体来说，我将在最先进的压力下训练 评估以及胎儿和早期儿童肺部发育和生理学与RJ赖特博士，2）培训 在Baccarelli博士实验室早期氧化应激生物标志物中， 时间分辨的每日至每周评估的暴露数据，以明确确定 提高我们发现影响和识别弱势群体的能力与布伦特库尔博士，4）整合研究 压力，空气污染和分子流行病学，通过与我的导师团队的互动，成为一个 我是一个跨学科的科学家，5）翻译我所接受的研究和管理培训，以建立自己的地位 作为一个独立的调查员与终身职位跟踪教师的立场，并定位自己为未来的R 01。 这项建议将解决在理解空气污染的时间和机制方面的差距， 暴露和压力会影响幼儿期的呼吸道健康。这项拟议的研究和培训计划 为独立的研究生涯奠定了基础，旨在澄清通过哪些机制， 环境空气污染和压力与呼吸道疾病有关， 干预/预防工作。这项研究也具有很高的成本效益，因为我们利用了 PROGRESS研究与现有的生物标本，环境和心理社会压力数据。

PROJECT SUMMARY I am an environmental epidemiologist with a primary research interest in the role of developmental windows, joint impact of multiple exposures and molecular mechanisms through which prenatal/early-life exposure to chemical and non-chemical stressors influence children's lung development. The goal of this proposal is to obtain training in the skills needed to continue to build my academic career by linking ambient air pollution and stress to lung development and to identify biomarkers of early biological effects of these exposures. Formal coursework and the expert mentorship of Drs. Rosalind Wright, Andrea Baccarelli, Robert Wright, Maria Martha Tellez-Rojo, Brent Coull, Alfin Vicencio and Allan Just will enable me to acquire the knowledge and skills necessary to become an independent transdisciplinary researcher. This training will allow me to achieve my long-term career goals: taking the lead in studying respiratory health in the ongoing Mexico City PROGRESS cohort in order to examine these and other environmental exposures, their biological mechanisms, and the subsequent effects on lung function and asthma risk longitudinally as these children grow up. All relevant exposure and covariate data exist in an existing well-phenotyped pregnancy cohort [Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) study leveraged herein. I will add respiratory phenotyping to the cohort. Specifically I will 1) train in state of the art stress assessment as well as fetal and early childhood lung development and physiology with Dr. RJ Wright, 2) train in early biologic markers of oxidative stress in Dr. Baccarelli's lab, 3) train in advanced statistical methods that temporal resolved daily to weekly assessed exposure data to definitively identify susceptibility windows to enhance our ability to find effects and identify vulnerable groups with Dr. Brent Coull, 4) integrate research on stress, air pollution and molecular epidemiology through interactions with my mentorship team to become an interdisciplinary scientist and 5) translate the research and administrative training I receive to establish myself as a independent investigator with a tenure track faculty position and to position myself for a future R01. This proposal will address gaps in the understanding of timing and mechanism through which air pollution exposure and stress affect respiratory health in early childhood. This proposed research and training plan builds the foundation for an independent research career that aims to clarify the mechanisms through which ambient air pollution and stress are associated with respiratory morbidity and ultimately inform intervention/prevention efforts. This study is also highly cost effective as we leverage the resources of the PROGRESS study with existing biospecimens, environmental and psychosocial stress data.