Ambient Air Pollution, Stress, Oxidative Markers and Respiratory Health in Mexican Children

墨西哥儿童的环境空气污染、压力、氧化标记物和呼吸系统健康

• 批准号: 10057382
• 负责人: Maria Jose Rosa
• 金额: $ 24.67万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-15 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10057382
• 关键词: 8 year old; Address; Affect; Age; Air Pollution; Asthma; Biological; Biological Markers; Birth; Bronchodilator Agents; Caliber; Cell physiology; Cells; Chemicals; Child; Childhood; Childhood Asthma; Chromosomes; Chronic; Cities; Cohort Studies; DNA Sequence; DNA copy number; Data; Development; Dose; Elderly; Environment; Environmental Exposure; Epidemiologist; Exposure to; Faculty; Foundations; Funding; Future; Goals; Growth; Growth and Development function; Health; Heterogeneity; Hydrocortisone; Impairment; Incidence; Intervention; Joints; Knowledge; Lead; Length; Leukocytes; Life; Link; Lung; Lung diseases; Measures; Mediation; Mediator of activation protein; Mentorship; Methods; Mexican; Mexico; Mitochondria; Mitochondrial DNA; Modeling; Molecular; Molecular Epidemiology; Nose; Obesity; Outcome; Oxidative Stress; Particulate Matter; Perinatal; Perinatal Exposure; Phenotype; Physiology; Play; Positioning Attribute; Predisposition; Pregnancy; Prevention; Prevention strategy; Psychosocial Stress; Pulmonary function tests; Reactive Oxygen Species; Reporting; Research; Research Personnel; Research Training; Resources; Respiration Disorders; Respiratory System; Respiratory physiology; Risk; Role; Salivary; Scientist; Source; Spirometry; Standardization; Statistical Methods; Stress; Structure; Surveys; Testing; Time; Toxic effect; Training; Translating; Vulnerable Populations; Wheezing; ambient air pollution; asthma exacerbation; base; career; cohort; cost effective; early childhood; early detection biomarkers; early life exposure; efficacious intervention; fetal; fine particles; in utero; indexing; interest; lung development; maternal stress; mitochondrial dysfunction; postnatal; prenatal; prenatal exposure; prospective; public health relevance; pulmonary function; respiratory; respiratory health; respiratory morbidity; skills; social stressor; statistics; stressor; telomere; tenure track

PROJECT SUMMARY I am an environmental epidemiologist with a primary research interest in the role of developmental windows, joint impact of multiple exposures and molecular mechanisms through which prenatal/early-life exposure to chemical and non-chemical stressors influence children's lung development. The goal of this proposal is to obtain training in the skills needed to continue to build my academic career by linking ambient air pollution and stress to lung development and to identify biomarkers of early biological effects of these exposures. Formal coursework and the expert mentorship of Drs. Rosalind Wright, Andrea Baccarelli, Robert Wright, Maria Martha Tellez-Rojo, Brent Coull, Alfin Vicencio and Allan Just will enable me to acquire the knowledge and skills necessary to become an independent transdisciplinary researcher. This training will allow me to achieve my long-term career goals: taking the lead in studying respiratory health in the ongoing Mexico City PROGRESS cohort in order to examine these and other environmental exposures, their biological mechanisms, and the subsequent effects on lung function and asthma risk longitudinally as these children grow up. All relevant exposure and covariate data exist in an existing well-phenotyped pregnancy cohort [Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) study leveraged herein. I will add respiratory phenotyping to the cohort. Specifically I will 1) train in state of the art stress assessment as well as fetal and early childhood lung development and physiology with Dr. RJ Wright, 2) train in early biologic markers of oxidative stress in Dr. Baccarelli's lab, 3) train in advanced statistical methods that temporal resolved daily to weekly assessed exposure data to definitively identify susceptibility windows to enhance our ability to find effects and identify vulnerable groups with Dr. Brent Coull, 4) integrate research on stress, air pollution and molecular epidemiology through interactions with my mentorship team to become an interdisciplinary scientist and 5) translate the research and administrative training I receive to establish myself as a independent investigator with a tenure track faculty position and to position myself for a future R01. This proposal will address gaps in the understanding of timing and mechanism through which air pollution exposure and stress affect respiratory health in early childhood. This proposed research and training plan builds the foundation for an independent research career that aims to clarify the mechanisms through which ambient air pollution and stress are associated with respiratory morbidity and ultimately inform intervention/prevention efforts. This study is also highly cost effective as we leverage the resources of the PROGRESS study with existing biospecimens, environmental and psychosocial stress data.

项目概要 我是一名环境流行病学家，主要研究发育窗口的作用， 多重暴露和产前/早期暴露的分子机制的共同影响 化学和非化学应激源会影响儿童的肺部发育。该提案的目标是 通过将环境空气污染与环境联系起来，获得继续发展学术生涯所需的技能培训 对肺部发育的压力并确定这些暴露的早期生物效应的生物标志物。 正式的课程和博士的专家指导。罗莎琳德·赖特、安德里亚·巴卡莱利、罗伯特·赖特、 Maria Martha Tellez-Rojo、Brent Coull、Alfin Vicencio 和 Allan Just 将使我能够获得知识 以及成为独立跨学科研究员所需的技能。这次培训将使我能够 实现我的长期职业目标：在墨西哥城带头研究呼吸健康 PROGRESS 队列以检查这些和其他环境暴露及其生物 机制，以及这些儿童对肺功能和哮喘风险的纵向影响 长大。所有相关暴露和协变量数据均存在于现有表型良好的妊娠队列中 [肥胖、生长、环境和社会压力因素的编程研究 (PROGRESS) 研究利用 在此处。我将在队列中添加呼吸表型分析。具体来说，我将 1）在最先进的压力下进行训练 与 RJ Wright 博士一起进行评估以及胎儿和幼儿肺部发育和生理学，2) 训练 Baccarelli 博士实验室的氧化应激早期生物标志物，3) 训练先进的统计方法， 每日到每周评估暴露数据的时间解析，以明确确定对病毒的敏感性窗口 与 Brent Coull 博士一起增强我们寻找影响和识别弱势群体的能力，4) 整合以下方面的研究： 通过与我的导师团队的互动，压力、空气污染和分子流行病学成为一名 跨学科科学家，5）翻译我接受的研究和行政培训，以建立自己的地位 作为一名拥有终身教职的独立调查员，并为自己定位未来的 R01。 该提案将解决对空气污染发生的时间和机制的理解上的差距。 接触和压力会影响幼儿时期的呼吸系统健康。本拟议的研究和培训计划 为独立研究生涯奠定基础，旨在阐明其机制 环境空气污染和压力与呼吸道疾病相关，并最终导致 干预/预防工作。这项研究也具有很高的成本效益，因为我们利用了 使用现有生物样本、环境和社会心理压力数据进行进展研究。

项目成果

Evidence establishing a link between prenatal and early-life stress and asthma development.

• DOI: 10.1097/aci.0000000000000421
• 发表时间: 2018-04
• 期刊: Current opinion in allergy and clinical immunology
• 影响因子: 2.8
• 作者: Rosa MJ;Lee AG;Wright RJ
• 通讯作者: Wright RJ

Dietary Fat Intake, Particulate Matter Exposure, and Asthma Severity.

膳食脂肪摄入量、颗粒物暴露和哮喘严重程度。

• DOI: 10.1164/rccm.201902-0296ed
• 发表时间: 2019
• 期刊: American journal of respiratory and critical care medicine
• 影响因子: 24.7
• 作者: Rosa,MariaJosé;Perzanowski,MatthewS
• 通讯作者: Perzanowski,MatthewS

Sex-specific associations between prenatal negative life events and birth outcomes.

产前负面生活事件与出生结果之间的性别特异性关联。

• DOI: 10.1080/10253890.2019.1608944
• 发表时间: 2019
• 期刊: Stress (Amsterdam, Netherlands)
• 作者: Rosa,MariaJosé;Nentin,Farida;BosquetEnlow,Michelle;Hacker,MicheleR;Pollas,Nastasia;Coull,Brent;Wright,RosalindJ
• 通讯作者: Wright,RosalindJ