The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) Cohort

项目总结/摘要 西奈山将与墨西哥国家公共卫生研究所和哥伦比亚大学合作， 继续跟踪2006年在墨西哥城建立的PROGRESS出生队列中的700名8-11岁儿童 研究围产期儿童发育的规划。PROGRESS是最先进的出生队列， 开发了创新的新方法来估计过去对环境化学品的暴露， 内部剂量的生物标志物（例如，基于牙齿的化学测定）和外部剂量的地理空间建模 通过遥感监测环境（如空气污染、绿色空间等）。此应用程序还将利用装载 西奈半岛最近成立的环境健康科学实验室，以建立在我们的国际 在儿童环境健康方面公认的研究专长。我们的使命是测量环境 在怀孕和儿童期暴露，以确定这些因素如何影响神经发育， 增长我们特别高兴地延长这项工作的进展，因为我们的首要目标是准备 迎接即将到来的经济学研究时代。在本R24中，我们将测试数据协调方法， 对未来的工作至关重要。通过与具有类似设计的队列的研究人员一起试用汇集方法，我们设置了 建立新的联盟，研究化学品、营养、社会因素和环境对健康的影响， 基因与环境的相互作用是儿童疾病的基础。我们的团队拥有所有必要的专业知识， 暴露科学、生物统计学、儿童健康表型分析和队列管理。我们已经 开发了几种新的方法来客观地重建过去的化学品暴露， 估计暴露时间，使研究人员能够确定易感性窗口，因为它们与儿童健康有关。 在过去的10年里，PROGRESS已经支持了16项由10名不同研究人员领导的NIH赠款（包括7名 K获奖者），展示了我们作为下一代环保孵化器的能力 健康科学家。为配合这类人士不同的研究需要，独立研究员成立了 相当于一个行政核心，通过协调和协调外地工作， 相关行政工作（IRB、方案制定、财务等）。我们还将开发新的 评估参与者需求的计划，以提高保留率，适应社交媒体的进步，评估 新的健康结果和暴露，并在我们准备队列时实施新的暴露/反应分析 为未来的大数据联盟研究。这项建议将经验丰富的环境卫生科学家 与统计学家、社会流行病学家、儿童心理学家、化学家、儿科医生和表观遗传学家一起， 支持一个高功能的基础设施，纵向出生队列的状态，客观地衡量 人类环境对儿童健康的影响。我们将跟踪进步儿童，直到 青春期，将胎儿暴露与这一关键生命阶段固有的健康变化联系起来。最后，尽管我们有许多 如果没有这种R24，现场工作将停止，这种应用对我们未来的成功至关重要。

PROJECT SUMMARY/ABSTRACT Mount Sinai will partner with the National Institute of Public Health, Mexico and Columbia University to continue to follow 700 children at ages 8-11 in the PROGRESS birth cohort established in 2006 in Mexico City to study perinatal programming of child development. PROGRESS is a state of the art birth cohort that has developed innovative new methods to estimate past exposure to environmental chemicals, both with biomarkers of internal dose (e.g. teeth based chemical assays) and with geospatial modeling of the external environment via remote sensing(e.g. air pollution, green space etc). This application will also leverage Mount Sinai's recently established Environmental Health Sciences Laboratory to build upon our internationally recognized research expertise in children's environmental health. Our mission is to measure environmental exposures across pregnancy and childhood to determine how these factors affect neurodevelopment and growth. We are especially excited to extend this work in PROGRESS as our overarching goal is to prepare the cohort the coming era of exposomic research. In this R24 we will test methods for data harmonization that will be critical to future work. By piloting pooling methods with researchers with similarly designed cohorts we set the stage to build new consortia to study the health impacts of chemicals, nutrition, social factors, and the gene-environment interactions that underlie childhood disease. Our team has all the requisite expertise in exposure science, biostatistics, child health phenotyping and in cohort management. We have already developed several new methodologies to objectively reconstruct past chemical exposures that precisely estimate exposure timing, allowing researchers to identify susceptibility windows as they relate to child health. Over the last 10 years, PROGRESS has supported 16 NIH grants led by 10 different researchers (including 7 K awardees), demonstrating our ability to serve as an incubator for the next generation of Environmental Health scientists. To accommodate divergent research needs among this group, the PI has formed the equivalent of an Administrative Core that will plan, organize, streamline and prioritize field work by coordinating the associated administrative work (IRB, protocol development, finances etc). We will also develop new programs to assess participant needs in order to improve retention, adapt to advances in social media, assess new health outcomes and exposures, and implement new exposure/response assays as we prepare our cohort for future big data consortia research. This proposal links highly experienced environmental health scientists with statisticians, social epidemiologists, child psychologists, chemists, pediatricians, and epigeneticists to support the infrastructure of a highly functional, state of the longitudinal birth cohort that objectively measures the human environments that program child health. We will follow PROGRESS children up to the onset of puberty, linking fetal exposures to health changes inherent to this critical life stage. Finally, despite our many successes, without this R24, field work will cease and this application is critical to our future success.