San Francisco Bay Clinical Trials Unit (CTU)

项目摘要 旧金山弗朗西斯科湾区经历了特别严重的艾滋病毒流行， 与男性发生性关系的人（MSM），黑人和拉丁裔人口受到最严重的影响， 区域;以及跨国界人士和注射毒品者是参与的重要人群。 Drs. Susan Buchbinder和Diane Havlir是艾滋病预防和治疗的科学领导者， 分别他们将共同领导旧金山弗朗西斯科湾区临床试验部门（SFBay CTU），隶属于ACTG，HPTN和HVTN。这一综合研究机构将 通过这些网络实现三个具体目标：1）促进预防和治疗 科学及其在临床试验网络中的交叉点; 2）实施临床试验 高效地遵守协议，同时吸引不同的社区;以及3） 培养新一代艾滋病毒预防和治疗科学的多元化领导者。Drs. Buchbinder和Havlir加入了一个多元化的人才库，他们提供了 在网络中担任领导职务，在众多科学领导委员会任职， 工作组和主持一系列预防和治疗方案。的两项临床 研究中心，Bridge HIV CRS（隶属于HVTN和HPTN，由Hyman博士领导 Scott）和UCSF CRS（隶属于ACTG，由Annie Leutkemeyer博士领导） 在入组、保留和遵守方案要求方面的卓越记录，以及 积极参与整个弗朗西斯科湾区的当地社区。本申请 代表旧金山湾反恐组的更新，有几个改进，包括新的领导 由一个有成就的，多样化的调查小组;将社区计划整合到一个 单一、地位中立的团队;扩大东部的社区参与和招聘 和旧金山弗朗西斯科;以及早期调查人员在各个方面的全面整合 旧金山湾反恐组的科学通过平稳运行的研究基础设施， 科学，运营和社区参与指导委员会，SFBay CTU 致力于继续在ACTG、HPTN和HVTN中发挥领导作用，并为 艾滋病预防、治疗和治愈科学的突破。

Project summary The San Francisco Bay Area has experienced a particularly intense HIV epidemic, with men who have sex with men (MSM), Black, and Latinx populations most heavily impacted in the region; and transpeople and people who inject drugs important populations for engagement. Drs. Susan Buchbinder and Diane Havlir are scientific leaders in HIV prevention and treatment, respectively. Together they will lead the San Francisco Bay Area Clinical Trials Unit (SFBay CTU), affiliated with the ACTG, HPTN, and HVTN. This integrated research organization will accomplish 3 specific aims through these Networks: 1) advance prevention and treatment science and their intersection within the Clinical Trials Networks; 2) implement clinical trials efficiently and with excellent adherence to protocol while engaging diverse communities; and 3) develop a new generation of diverse leaders in HIV prevention and treatment science. Drs. Buchbinder and Havlir are joined by a diverse pool of talented investigators who have provided leadership across the Networks, serving on numerous scientific leadership committees and working groups and chairing a range of prevention and treatment protocols. The two Clinical Research Sites, the Bridge HIV CRS (affiliated with HVTN and HPTN and led by Dr. Hyman Scott) and the UCSF CRS (affiliated with ACTG and led by Dr. Annie Leutkemeyer) have records of excellence in enrollment, retention, and adherence to protocol requirements, and actively engage local communities throughout the San Francisco Bay Area. This application represents a renewal of the SFBay CTU, with several improvements, including new leadership by an accomplished, diverse group of investigators; integration of community programs into a single, status-neutral team; expansion of community engagement and recruitment into the East and South Bays of San Francisco; and full integration of early stage investigators in all aspects of the science of the SFBay CTU. Through a smoothly running research infrastructure, divided into Scientific, Operational, and Community Engagement Steering Committees, the SFBay CTU is committed to continued leadership in the ACTG, HPTN, and HVTN, and contributing to breakthroughs in the science of HIV prevention, treatment, and cure.